Effects of biological and non-biological immunomodulatory therapies on the immunogenicity of vaccines in patients with rheumatic diseases
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  • 作者:Zsuzsanna H McMahan (1)
    Clifton O Bingham III (1)

    1. Department of Medicine
    ; Division of Rheumatology ; Johns Hopkins University ; 5200 Eastern Avenue ; Mason F Lord Center Tower ; Room 4100 ; Baltimore ; MD ; 21224 ; USA
  • 刊名:Arthritis Research & Therapy
  • 出版年:2014
  • 出版时间:December 2014
  • 年:2014
  • 卷:16
  • 期:6
  • 全文大小:433 KB
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  • 刊物主题:Rheumatology; Orthopedics;
  • 出版者:BioMed Central
  • ISSN:1478-6354
文摘
Vaccinations are administered to patients to induce a protective immune response, resulting in immunological memory. Preventing infection through the use of vaccines is particularly important in immunocompromised and immunosuppressed individuals given their increased frequency and severity of infections relative to healthy individuals. Recent surveys show that the vaccination rate is still alarmingly low in patients with rheumatic disease. In this review we briefly discuss the different types of vaccines and then critically examine evidence related to vaccination efficacy in patients with autoimmune disease and the effects of immunomodulatory therapy, with an aim to provide guidance and optimize the administration of vaccines in such individuals.

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