The effects of the novel DA D3 receptor antagonist SR 21502 on cocaine reward, cocaine seeking and cocaine-induced locomotor activity in rats
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- 作者：E. Galaj (1)
S. Ananthan (3)
M. Saliba (2)
Robert Ranaldi (1) (2) (4) - 关键词：Reward ; Relapse ; D3 receptor ; Food reward ; Locomotor activity
- 刊名：Psychopharmacology
- 出版年：2014
- 出版时间：February 2014
- 年：2014
- 卷：231
- 期：3
- 页码：501-510
- 全文大小：354 KB
- 作者单位：E. Galaj (1)
S. Ananthan (3)
M. Saliba (2)
Robert Ranaldi (1) (2) (4)
1. Neuropsychology Doctoral Program, CUNY Graduate Center, New York, NY, USA
3. Organic Chemistry Department, Southern Research Institute, Birmingham, AL, USA
2. Department of Psychology, Queens College of the City University of New York, Queens, NY, USA
4. Psychology Department, Queens College, 65-30 Kissena Blvd, Flushing, NY, 11367, USA - ISSN：1432-2072
文摘
Rationale There is a focus on developing D3 receptor antagonists as cocaine addiction treatments. Objective We investigated the effects of a novel selective D3 receptor antagonist, SR 21502, on cocaine reward, cocaine-seeking, food reward, spontaneous locomotor activity and cocaine-induced locomotor activity in rats. Methods In Experiment 1, rats were trained to self-administer cocaine under a progressive ratio (PR) schedule of reinforcement and tested with vehicle or one of three doses of SR 21502. In Experiment 2, animals were trained to self-administer cocaine under a fixed ratio schedule of reinforcement followed by extinction of the response. Then, animals were tested with vehicle or one of the SR 21502 doses on cue-induced reinstatement of responding. In Experiment 3, animals were trained to lever press for food under a PR schedule and tested with vehicle or one dose of the compound. In Experiments 4 and 5, in separate groups of animals, the vehicle and three doses of SR 21502 were tested on spontaneous or cocaine (10?mg/kg, IP)-induced locomotor activity, respectively. Results SR 21502 produced significant, dose-related (3.75, 7.5 and 15?mg/kg) reductions in breakpoint for cocaine self-administration, cue-induced reinstatement (3.75, 7.5 and 15?mg/kg) and cocaine-induced locomotor activity (3.75, 7.5 and 15?mg/kg) but failed to reduce food self-administration and spontaneous locomotor activity. Conclusions SR 21502 decreases cocaine reward, cocaine-seeking and locomotor activity at doses that have no effect on food reward or spontaneous locomotor activity. These data suggest SR 21502 may selectively inhibit cocaine’s rewarding, incentive motivational and stimulant effects.