Selective AKT Inhibition by MK-2206 Represses Colorectal Cancer-Initiating Stem Cells

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• 作者：Patrizia Malkomes MD ; Ilaria Lunger MSc…
• 刊名：Annals of Surgical Oncology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：23
• 期：9
• 页码：2849-2857
• 全文大小：1,272 KB
• 刊物主题：Surgical Oncology; Oncology; Surgery;
• 出版者：Springer US
• ISSN：1534-4681
• 卷排序：23

文摘

BackgroundColorectal cancer (CRC) is a leading cause of cancer-related death worldwide. Growing evidence indicates that tumor-initiating cells (TICs) are responsible for tumor growth and progression. Conventional chemotherapeutics do not sufficiently eliminate TICs, leading to tumor relapse. We aimed to gain insight into TIC biology by comparing the transcriptome of primary TIC cultures and their normal stem cell counterparts to uncover expression differences.