Isolation of actinium-225 for medical purposes

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• 作者：A. A. Kotovskii ; N. A. Nerozin ; I. V. Prokof’ev ; V. V. Shapovalov…
• 关键词：actinium ; 225 ; thorium ; 229 ; radium ; 225 ; nuclear medicine ; ion exchange
• 刊名：Radiochemistry
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：57
• 期：3
• 页码：285-291
• 全文大小：234 KB
• 参考文献：1.Huber, R., Seidl, Ch., Schmid, E., et al., Clin. Cancer Res., 2003, vol. 9, no. 10, part 2, pp. 3922S-928S.
  2.Jurcic, J., Larson, S., Sqouros, G., et al., Blood, 2002, vol. 100, no. 4, pp. 1233-239.
  3.Qu, C., Song, Y., Li, Y., et al., Br. J. Cancer, 2004, vol. 91, no. 12, pp. 2086-093.View Article
  4.Vandenbulcke, K., Thierens, H., Offner, F., et al., Nucl. Med. Commun., 2004, vol. 25, no. 11, pp. 1131-136.View Article
  5.Beyer, G., Miederer, M., Vranjes-Duric, S., et al., Eur. J. Nucl. Med. Imag., 2004, vol. 31, no. 4, pp. 547-54.View Article
  6.Dadachova, E., Bryan, R., Frenkel, A., et al., Antimicrob. Agents Chemother., 2004, vol. 48, no. 3, pp. 1004-006.View Article
  7.Khalkin, V.A., Tsupko-Sitnikov, V.V., and Zaitseva, N.G., Radiochemistry, 1997, vol. 39, no. 6, pp. 481-89.
  8.Boll, R., Malkemus, D., and Mirzadeh, S., Appl. Radiat. Isot., 2005, vol. 62, no. 5, pp. 667-79.View Article
  9.Apostolidis, C., Molinet, R., Rasmussen, G., and Morgenstern, A., Anal. Chem., 2005, vol. 77, no. 19, pp. 6288-291.View Article
  10.Molinet, R., Janssens, W., Apostolidis, C., and Koch, L., in Proc. 4th Int Conf. on Nuclear and Radiochemistry, Saint-Malo (France), Sept. 8-3, 1996, Orsay, 1996, H-P2.
  11.Manochin, V.N., Panchenko, A.B., Plyaskin, V.I., et al., Handbook of nuclear activation data, Tech. Rep. Ser., Vienna: IAEA, 1987, no. 273, p. 305.
  12.Apostolidis, C., Molinet, R., McGinly, J., et al., Appl. Radiat. Isot., 2005, vol. 62, no. 3, pp. 383-87.View Article
  13.Pavlovich, V.B., Dubinkin, D.O., Kotovskii, A.A., et al., RF Patent 2 200 581, 2003, Byull. Izobret., 2003, no. 3.
  14.Nerozin, N.A., Shapovalov, V.V., Kotovskii, A.A., et al., RF Patent 2 441 687, 2012, Byull. Izobret., 2012, no. 4.
  15.Lavrukhina, A.K., Alekseev, A.V., Gorin, V.D., and Ivliev, A.I., Nizkofonovaya dozimetriya (Low-Background Dosimetry), Moscow: Nauka, 1992.
  
• 作者单位：A. A. Kotovskii (1)
  N. A. Nerozin (1)
  I. V. Prokof’ev (1)
  V. V. Shapovalov (1)
  Yu. A. Yakovshchits (1)
  A. S. Bolonkin (1)
  A. V. Dunin (1)
  
  1. Leipunskii Institute for Physics and Power Engineering, pl. Bondarenko 1, Obninsk, Kaluga oblast, Russia
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nuclear Chemistry
  Chemistry
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1608-3288

文摘

A procedure is described for isolation and purification of 225Ac as a 229Th daughter decay product using ion exchange. The process includes the following steps: separation of 229Th from a mixture of 225Ac and 225Ra (225Ac precursor) using an anion-exchange resin; separation of 225Ac and 225Ra using a cation-exchange resin; purification of 225Ac to remove inactive impurity cations (primarily Fe) using an anion-exchange resin; final purification of the product on a column with a cation-exchange resin.