Ustekinumab in the Treatment of Psoriasis and Psoriatic Arthritis

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• 作者：Laura J. Savage ; Miriam Wittmann ; Dennis McGonagle…
• 关键词：IL ; 12/IL ; 23 inhibition ; Psoriasis ; Psoriatic arthritis ; Treatment ; Ustekinumab
• 刊名：Rheumatology and Therapy
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：2
• 期：1
• 页码：1-16
• 全文大小：638KB
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• 作者单位：Laura J. Savage (1)
  Miriam Wittmann (1) (2) (3)
  Dennis McGonagle (1) (2)
  Philip S. Helliwell (1)
  
  1. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK
  2. NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, UK
  3. Centre for Skin Sciences, School of Life Sciences, University of Bradford, Bradford, UK
  
• 刊物类别：Rheumatology; Orthopedics; General Practice / Family Medicine; Internal Medicine; Quality of Life Re
• 刊物主题：Rheumatology; Orthopedics; General Practice / Family Medicine; Internal Medicine; Quality of Life Research;
• 出版者：Springer Healthcare
• ISSN：2198-6584

文摘

Biologics have revolutionized the therapy of the psoriatic disease spectrum. These new classes of drugs also allow deeper insight into the pathogenesis of the disease and highlight the existence of distinct 鈥渕olecular鈥?disease subgroups as evidenced by the spectrum of clinical response seen. Molecules associated with both the interleukin (IL)-17 and interferon (IFN)纬 pathways have important functions in psoriatic inflammation, and both are targeted by drugs acting on the p40 subunit shared by IL-12 and IL-23. These IL-12 family members are upstream of pathways characterized by the production of IFN纬 and IL-17 related molecules, including IL-17, IL-22, and CCL20. We here summarize the mode of action and clinical studies of the p40 inhibitor ustekinumab with focus on both psoriasis and psoriatic arthritis. Keywords IL-12/IL-23 inhibition Psoriasis Psoriatic arthritis Treatment Ustekinumab