Brain iron redistribution in mesial temporal lobe epilepsy: a susceptibility-weighted magnetic resonance imaging study

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• 作者：Zhiqiang Zhang (1)
  Wei Liao (1) (2)
  Boris Bernhardt (3)
  Zhengge Wang (1)
  Kangjian Sun (4)
  Fang Yang (5)
  Yijun Liu (6)
  Guangming Lu (1)
  
  1. Department of Medical Imaging ; Jinling Hospital ; Nanjing University School of Medicine ; 305# Eastern Zhongshan Rd ; Nanjing ; 210002 ; China
  2. Center for Cognition and Brain Disorders ; Affiliated Hospital of Hangzhou Normal University ; Hangzhou ; 310015 ; China
  3. Department of Social Neuroscience ; Max Planck Institute for Human Cognitive and Brain Science ; Leipzig ; Germany
  4. Department of Neurosurgery ; Jinling Hospital ; Nanjing University School of Medicine ; Nanjing ; 210002 ; China
  5. Department of Neurology ; Jinling Hospital ; Nanjing University School of Medicine ; Nanjing ; 210002 ; China
  6. Department of Psychiatry and Neuroscience ; University of Florida ; Gainesville ; Fl ; USA
  
• 关键词：Brain iron ; Mesial temporal lobe epilepsy ; Susceptibility ; weighted magnetic resonance imaging
• 刊名：BMC Neuroscience
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：15
• 期：1
• 全文大小：1,480 KB
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• 刊物主题：Neurosciences; Neurobiology; Animal Models;
• 出版者：BioMed Central
• ISSN：1471-2202

文摘

Background The roles of iron in epilepsy and its pathophysiological significance are poorly understood, especially whether iron levels are abnormal in subcortcal structures. This study aims to demonstrate whole-brain iron alterations and its clinical relevancies in mesial temporal lobe epilepsy (mTLE) in vivo, using susceptibility-weighted magnetic resonance imaging (SWI). Methods We studied 62 patients with mTLE and 62 healthy controls. Brain iron concentration was quantified using SWI phase values. Voxel-wise analysis was carried out to compare iron levels between mTLE and controls, and to assess the relationship between altered iron concentration and clinical parameters in mTLE. Results Patients with mTLE showed decreases of iron levels in the subcortical structures such as substantia nigra, red nucleus, and basal ganglia. Conversely, iron levels were decreased in the cortex. Subcortical iron levels were negatively correlated to those in the cortex. Moreover, cortical and basal ganglia iron levels were related to clinical variables including epilepsy duration, age at seizures onset, and histories of precipitating factors. Conclusions Our SWI findings suggest a redistribution of iron between subcortical and cortical structures in mTLE. The degree of redistribution is affected by both progression of epilepsy and precipitating factors. Investigation on brain iron redistribution offers new insights into the pathogenesis of mTLE, and may be a potential biomarker for monitoring the clinical progression of epilepsy.