Distinct profiles of myositis-specific autoantibodies in Chinese and Japanese patients with polymyositis/dermatomyositis

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• 作者：Zhiyong Chen ; Wei Hu ; Yan Wang ; Ziwei Guo ; Lingyun Sun…
• 关键词：Autoantibodies-lt ; ?Tissues or models ; Myositis-lt ; ?Rheumatic diseases
• 刊名：Clinical Rheumatology
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：34
• 期：9
• 页码：1627-1631
• 全文大小：129 KB
• 参考文献：1.Mammen AL (2010) Dermatomyositis and polymyositis: clinical presentation, autoantibodies, and pathogenesis. Ann N Y Acad Sci 1184:134-53. doi:10.-111/?j.-749-6632.-009.-5119.?x CrossRef PubMed
  2.Sontheimer RD (2010) Clinically amyopathic dermatomyositis: what can we now tell our patients? Arch Dermatol 146(1):76-0. doi:10.-001/?archdermatol.-009.-23 CrossRef PubMed
  3.Mimori T, Imura Y, Nakashima R, Yoshifuji H (2007) Autoantibodies in idiopathic inflammatory myopathy: an update on clinical and pathophysiological significance. Curr Opin Rheumatol 19(6):523-29. doi:10.-097/?BOR.-b013e3282f01a8c-/span> CrossRef PubMed
  4.Sato S, Hoshino K, Satoh T, Fujita T, Kawakami Y, Fujita T, Kuwana M (2009) RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: association with rapidly progressive ILD. Arthritis Rheum 60:2193-200. doi:10.-002/?art.-4621 CrossRef PubMed
  5.Chen Z, Cao M, Plana MN, Liang J, Cai H, Kuwana M, Sun L (2013) Utility of anti-melanoma differentiation-associated gene 5 antibody measurement in identifying patients with dermatomyositis and a high risk for developing rapidly progressive interstitial lung disease: a review of the literature and a meta-analysis. Arthritis Care Res 65(8):1316-324. doi:10.-002/?acr.-1985 CrossRef
  6.Sato S, Kuwana M (2010) Clinically amyopathic dermatomyositis. Curr Opin Rheumatol 22:639-43. doi:10.-097/?BOR.-b013e32833f1987-/span> CrossRef PubMed
  7.Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, Lynch DA, Ryu JH, Swigris JJ, Wells AU, Ancochea J, Bouros D, Carvalho C, Costabel U, Ebina M, Hansell DM, Johkoh T, Kim DS, King TE Jr, Kondoh Y, Myers J, Muller NL, Nicholson AG, Richeldi L, Selman M, Dudden RF, Griss BS, Protzko SL, Schunemann HJ (2011) An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 183(6):788-24. doi:10.-164/?rccm.-009-040GL CrossRef PubMed
  8.Ikeda N, Takahashi K, Yamaguchi Y, Inasaka M, Kuwana M, Ikezawa Z (2011) Analysis of dermatomyositis-specific autoantibodies and clinical characteristics in Japanese patients. J Dermatol 38(10):973-79. doi:10.-111/?j.-346-8138.-011.-1262.?x CrossRef PubMed
  9.Kang EH, Kuwana M, Okazaki Y, Lee EY, Lee YJ, Lee EB, Song YW (2014) Comparison of radioimmunoprecipitation versus antigen-specific assays for identification of myositis-specific autoantibodies in dermatomyositis patients. Mod Rheumatol Jpn Rheum Assoc 24(6):945-48. doi:10.-109/-4397595.-014.-96494 CrossRef
  10.Labrador-Horrillo M, Martinez MA, Selva-O'Callaghan A, Trallero-Araguas E, Balada E, Vilardell-Tarres M, Juárez C (2014) Anti-MDA5 antibodies in a large Mediterranean population of adults with dermatomyositis. J Immunol Res 2014:8. doi:10.-155/-014/-90797 CrossRef
  11.Chinoy H, Lamb JA, Ollier WE, Cooper RG (2011) Recent advances in the immunogenetics of idiopathic inflammatory myopathy. Arthritis Res Ther 13(3):216. doi:10.-186/?ar3327 PubMed Central CrossRef PubMed
  12.Arnett FC, Targoff IN, Mimori T, Goldstein R, Warner NB, Reveille JD (1996) Interrelationship of major histocompatibility complex class II alleles and autoantibodies in four ethnic groups with various forms of myositis. Arthritis Rheum 39(9):1507-518CrossRef PubMed
  13.Furuya T, Hakoda M, Tsuchiya N, Kotake S, Ichikawa N, Nanke Y, Nakajima A, Takeuchi M, Nishinarita M, Kondo H, Kawasaki A, Kobayashi S, Mimori T, Tokunaga K, Kamatani N (2004) Immunogenetic features in 120 Japanese patients with idiopathic inflammatory myopathy. J Rheumatol 31(9):1768-774PubMed
  14.Gono T, Kawaguchi Y, Kuwana M, Sugiura T, Furuya T, Takagi K, Ichida H, Katsumata Y, Hanaoka M, Ota Y, Yamanaka H (2012) Brief report: Association of HLA-DRB1*0101/*0405 with susceptibility to anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis in the Japanese population. Arthritis Rheum 64(11):3736-740. doi:10.-002/?art.-4657 CrossRef PubMed
  15.Nakajima F, Nakamura J, Yokoda T (2001) HLA haplotype distribution of Japanese. MHC 8(1):1-2 (in Japanese)
  16.Qin Qin P, Su F, Xiao Yan W, Xing Z, Meng P, Chengya W, Jie S (2011) Distribution of human leucocyte antigen-A, -B and -DR alleles and haplotypes at high resolution in the population from Jiangsu province of China. Int J Immunogenet 38(6):475-81. doi:10.-111/?j.-744-313X.-011.-1029.?x CrossRef PubMed
  17.Chinoy H, Adimulam S, Marriage F, New P, Vincze M, Zilahi E, Kapitany A, Gyetvai A, Ekholm L, Novota P, Remakova M, Charles P, McHugh NJ, Padyukov L, Alfredsson L, Vencovsky J, Lundberg IE, Danko K, Ollier WE, Cooper RG (2012) Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: a European-wide case study. Ann Rheum Dis 71(6):
• 作者单位：Zhiyong Chen (1)
  Wei Hu (2)
  Yan Wang (1)
  Ziwei Guo (1)
  Lingyun Sun (1)
  Masataka Kuwana (3)
  
  1. Department of Rheumatology and Immunology, Affiliated Drum Tower Hospital, Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, China
  2. Department of Clinical Laboratory, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
  3. Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  
• 出版者：Springer London
• ISSN：1434-9949

文摘

The study aims to comprehensively assess the profiles of myositis-specific autoantibodies (MSAs) in Chinese patients with polymyositis (PM)/dermatomyositis (DM) and compare them with a Japanese cohort. One hundred forty-five Chinese patients (68 classic DM, 25 clinically amyopathic DM [CADM], and 52 PM) and 165 Japanese patients (56 classic DM, 52 CADM, and 57 PM) were recruited. MSAs were measured with immunoprecipitation, enzyme-linked immunosorbent assay, or immunoprecipitation–immunoblotting. MSA frequencies were compared. The overall frequency of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies was significantly higher in the Chinese patients than in the Japanese cohort (36.6 % [53/145] versus 15.8 % [26/165], respectively, P-lt;-.001), whereas the frequencies of anti-signal recognition particle (SRP) antibodies (1.4 % [2/145] versus 7.9 % [13/165], respectively, P--.008) and anti-aminoacyl-transfer RNA synthetase (anti-ARS) antibodies (27.6 % [40/145] versus 40 % [66/165], respectively, P--.02,) were significantly lower. The significantly lower frequency of anti-ARS antibodies and significantly higher frequency of anti-MDA5 antibodies in the Chinese patients were observed in the classic DM subset (14.7 % [10/68] versus 46.4 % [26/56], respectively, P-lt;-.001, and 45.6 % [31/68] versus 5.4 % [3/56], respectively, P-lt;-.001) and CADM subset (8.0 % [2/25] versus 28.8 % [15/52], respectively, P--.04, and 88.0 % [22/25] versus 44.2 % [23/52], respectively, P--.0002), but not in the PM subset. The first detailed profile of MSAs in Chinese patients with PM/DM was established. The differences in MSA frequencies in the Chinese cohort and Japanese cohort suggest underlying genetic and/or environmental differences between these two populations. Key Messages -A significantly higher frequency of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies was observed in Chinese patients with polymyositis/dermatomyositis (PM/DM) than in Japanese patients. -Our findings suggest that distinct genetic and/or local environmental factors affect Chinese and Japanese patients with PM/DM, who have been considered a “homogeneous-population in previous studies. Keywords Autoantibodies-lt;?Tissues or models Myositis-lt;?Rheumatic diseases