The effect of bone marrow concentrate and hyperbaric oxygen therapy on bone repair

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• 作者：J. P. Grassmann (1)
  J. Schneppendahl (1)
  M. Sager (2)
  A. R. Hakimi (3)
  M. Herten (4)
  T. T. Loegters (1)
  M. Wild (1)
  M. Hakimi (1)
  J. Windolf (1)
  P. Jungbluth (1)
  
  1. Department of Trauma and Handsurgery ; Heinrich Heine University Hospital Duesseldorf ; Moorenstr. 5 ; 40225 ; Duesseldorf ; Germany
  2. Heinrich Heine University Hospital Duesseldorf ; Animal Research Institute ; Moorenstr. 5 ; 40225 ; Duesseldorf ; Germany
  3. Department of Oral Surgery ; Heinrich Heine University Hospital Duesseldorf ; Moorenstr. 5 ; 40225 ; Duesseldorf ; Germany
  4. Department of Orthopaedics ; Heinrich Heine University Hospital Duesseldorf ; Moorenstr. 5 ; 40225 ; Duesseldorf ; Germany
  
• 刊名：Journal of Materials Science Materials in Medicine
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：26
• 期：1
• 全文大小：2,328 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Biomaterials
  Characterization and Evaluation Materials
  Polymer Sciences
  Metallic Materials
  Ceramics,Glass,Composites,Natural Materials
  Surfaces and Interfaces and Thin Films
  
• 出版者：Springer Netherlands
• ISSN：1573-4838

文摘

Neoangiogenesis represents an essential part of bone regeneration. Therefore the improvement of neovascularization is the subject of various research approaches. In addition autologous mesenchymal stem cells concentrate in combination with bone substitute materials have been shown to support bone regeneration. In a rabbit model we examined the proposed synergistic effect of hyperbaric oxygen therapy (HBOT) and bone marrow concentrate (BMC) with porous calcium phosphate granules (CPG) on neoangiogenesis and osseous consolidation of a critical- size defect. The animal groups treated with HBOT showed a significantly higher microvessel density (MVD) by immunhistochemistry. Furthermore HBOT groups presented a significantly larger amount of new bone formation histomorphometrically as well as radiologically. We conclude that the increase in perfusion as a result of increased angiogenesis may play a key role in the effects of HBOT and consequently promotes bone healing.