Therapiestrategie bei systemischem Lupus erythematodes

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• 作者：Prof. Dr. M. Schneider (1)
  
  1. Poliklinik und Funktionsbereich f眉r Rheumatologie UKD ; Heinrich-Heine-Universit盲t D眉sseldorf ; Moorenstr. 5 ; 40225 ; D眉sseldorf ; Deutschland
  
• 关键词：Remission ; Strategie ; Rheumatoide Arthritis ; Krankheitsaktivit盲t ; Organmanifestationen ; Remission ; Strategy ; Rheumatoid arthritis ; Disease activity ; Organ manifestation
• 刊名：Zeitschrift f篓鹿r Rheumatologie
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：74
• 期：3
• 页码：199-205
• 全文大小：492 KB
• 参考文献：1. Aringer M, Houssiau F, Gordon C et al (2009) Adverse events and efficacy of TNF-alpha blockade with infliximab in patients with systemic lupus erythematosus: long-term follow-up of 13 patients. Rheumatology (Oxford) 48(11):1451鈥?454
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  23. Wikipedia 鈥揝trategie. http://de.wikipedia.org/wiki/Strategie
  
• 刊物主题：Internal Medicine; Rheumatology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1435-1250

文摘

Therapeutic strategy means the definition of a long-term target, which should be reached by a chosen management. As for rheumatoid arthritis, the treat to target initiative recommends remission as the target for systemic lupus erythematosus (SLE) but the command variables of remission are not yet defined. The basis of a therapeutic strategy is first the analysis of those factors that may influence the achievement of the objectives: SLE disease activity, the differentiation of damage, organ manifestations, comorbidities, genetics, sex, age of onset and considering the pathophysiological basis are some of these factors. The next step is the analysis of the available substances and concepts that allow the target to be reached. Finally, rules for management (e.g. guidelines) are needed that enrich the possibility to reach the target and improve the prognosis of patients suffering from SLE.