Liver myofibroblasts from hepatitis B related liver failure patients may regulate natural killer cell function via PGE2

详细信息    查看全文

• 作者：Min Zhang (1)
  Fenglan Wang (2) (3)
  Yutian Chong (1)
  Qiang Tai (4)
  Qiyi Zhao (1)
  Yubao Zheng (1)
  Liang Peng (1)
  Shumei Lin (2)
  Zhiliang Gao (1)
  
  1. Department of Infectious Diseases ; Third Affiliated Hospital of Sun Yat-sen University ; No. 600 Tianhe Road ; Guangzhou ; 510630 ; Guangdong Province ; China
  2. Department of Infectious Diseases ; First Affiliated Hospital of Medical College of Xi鈥瞐n Jiaotong University ; No. 277 Yanta West Road ; Xi鈥瞐n ; 710061 ; Shanxi Province ; China
  3. Department of Infectious Diseases ; the Eighth Hospital of Xi鈥瞐n ; Xi鈥瞐n ; China
  4. Department of Hepatic Surgury ; First Affiliated Hospital of Sun Yat-sen University ; Guangzhou ; China
  
• 关键词：Liver myofibroblasts ; Natural killer cell ; Immune ; mediated liver injury ; Liver failure ; Hepatitis B
• 刊名：Journal of Translational Medicine
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：12
• 期：1
• 全文大小：2,782 KB
• 参考文献：1. Laleman, W, Wilmer, A, Evenepoel, P, Verslype, C, Fevery, J, Nevens, F (2006) Review article: non-biological liver support in liver failure. Aliment Pharmacol Ther 23: pp. 351-363 CrossRef
  2. Wu, Z, Han, M, Chen, T, Yan, W, Ning, Q (2010) Acute liver failure: mechanisms of immune-mediated liver injury. Liver Int 30: pp. 782-794 CrossRef
  3. Laleman, W, Verbeke, L, Meersseman, P, Wauters, J, Pelt, J, Cassiman, D, Wilmer, A, Verslype, C, Nevens, F (2011) Acute-on-chronic liver failure: current concepts on definition, pathogenesis, clinical manifestations and potential therapeutic interventions. Expert Rev Gastroenterol Hepatol 5: pp. 523-537 CrossRef
  4. Liu, Q, Liu, Z, Wang, T, Wang, Q, Shi, X, Dao, W (2007) Characteristics of acute and sub-acute liver failure in China: nomination, classification and interval. J Gastroenterol Hepatol 22: pp. 2101-2106 CrossRef
  5. Trinchieri, G (1989) Biology of natural killer cells. Adv Immunol 47: pp. 187-376 CrossRef
  6. Cerwenka, A, Lanier, LL (2001) Natural killer cells, viruses and cancer. Nat Rev Immunol 1: pp. 41-49 CrossRef
  7. French, AR, Yokoyama, WM (2003) Natural killer cells and viral infections. Curr Opin Immunol 15: pp. 45-51 CrossRef
  8. Nakatani, K, Kaneda, K, Seki, S, Nakajima, Y (2004) Pit cells as liver-associated natural killer cells: morphology and function. Med Electron Microsc 37: pp. 29-36 CrossRef
  9. Mackay, IR (2002) Hepatoimmunology: a perspective. Immunol Cell Biol 80: pp. 36-44 CrossRef
  10. Gao, B, Radaeva, S, Park, O (2009) Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases. J Leukoc Biol 86: pp. 513-528
  11. Ochi, M, Ohdan, H, Mitsuta, H, Onoe, T, Tokita, D, Hara, H, Ishiyama, K, Zhou, W, Tanaka, Y, Asahara, T (2004) Liver NK cells expressing TRAIL are toxic against self hepatocytes in mice. Hepatology 39: pp. 1321-1331 CrossRef
  12. Zou, Y, Chen, T, Han, M, Wang, H, Yan, W, Song, G, Wu, Z, Wang, X, Zhu, C, Luo, X, Ning, Q (2010) Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure. J Immunol 184: pp. 466-475 CrossRef
  13. Dong, Z, Wei, H, Sun, R, Hu, Z, Gao, B, Tian, Z (2004) Involvement of natural killer cells in PolyI:C-induced liver injury. J Hepatol 41: pp. 966-973 CrossRef
  14. Dunn, C, Brunetto, M, Reynolds, G, Christophides, T, Kennedy, PT, Lampertico, P, Das, A, Lopes, AR, Borrow, P, Williams, K, Humphreys, E, Afford, S, Adams, DH, Bertoletti, A, Maini, MK (2007) Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. J Exp Med 204: pp. 667-680 CrossRef
  15. Liu, M, Mendicino, M, Ning, Q, Ghanekar, A, He, W, McGilvray, I, Shalev, I, Pivato, D, Clark, DA, Phillips, MJ, Levy, GA (2006) Cytokine-induced hepatic apoptosis is dependent on FGL2/fibroleukin: the role of Sp1/Sp3 and STAT1/PU.1 composite cis elements. J Immunol 176: pp. 7028-7038 CrossRef
  16. Liu, ZX, Govindarajan, S, Kaplowitz, N (2004) Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology 127: pp. 1760-1774 CrossRef
  17. Filer, A, Parsonage, G, Smith, E, Osborne, C, Thomas, AM, Curnow, SJ, Rainger, GE, Raza, K, Nash, GB, Lord, J, Salmon, M, Buckley, CD (2006) Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils. Arthritis Rheum 54: pp. 2096-2108 CrossRef
  18. Nazareth, MR, Broderick, L, Simpson-Abelson, MR, Kelleher, RJ, Yokota, SJ, Bankert, RB (2007) Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells. J Immunol 178: pp. 5552-5562 CrossRef
  19. Balsamo, M, Scordamaglia, F, Pietra, G, Manzini, C, Cantoni, C, Boitano, M, Queirolo, P, Vermi, W, Facchetti, F, Moretta, A, Moretta, L, Mingari, MC, Vitale, M (2009) Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity. Proc Natl Acad Sci U S A 106: pp. 20847-20852 CrossRef
  20. Henderson, NC, Iredale, JP (2007) Liver fibrosis: cellular mechanisms of progression and resolution. Clin Sci (Lond) 112: pp. 265-280 CrossRef
  21. Jiao, J, Friedman, SL, Aloman, C (2009) Hepatic fibrosis. Curr Opin Gastroenterol 25: pp. 223-229 CrossRef
  22. Holt, AP, Haughton, EL, Lalor, PF, Filer, A, Buckley, CD, Adams, DH (2009) Liver myofibroblasts regulate infiltration and positioning of lymphocytes in human liver. Gastroenterology 136: pp. 705-714 CrossRef
  23. Chinnadurai, R, Grakoui, A (2010) B7-H4 mediates inhibition of T cell responses by activated murine hepatic stellate cells. Hepatology 52: pp. 2177-2185 CrossRef
  24. Schildberg, FA, Wojtalla, A, Siegmund, SV, Endl, E, Diehl, L, Abdullah, Z, Kurts, C, Knolle, PA (2011) Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism. Hepatology 54: pp. 262-272 CrossRef
  25. Zhang, M, Ye, Y, Wang, F, Zhu, J, Zhao, Q, Zheng, Y, Gu, Y, Xie, C, Huang, Z, Tai, Q, Chong, Y, Gao, Z (2014) Liver myofibroblasts up-regulate monocyte CD163 expression via PGE2 during hepatitis B induced liver failure. J Transl Med 12: pp. 60 CrossRef
  26. Kuang, DM, Peng, C, Zhao, Q, Wu, Y, Zhu, LY, Wang, J, Yin, XY, Li, L, Zheng, L (2010) Tumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients. J Immunol 185: pp. 1544-1549 CrossRef
  27. Pradier, A, Passweg, J, Villard, J, Kindler, V (2011) Human bone marrow stromal cells and skin fibroblasts inhibit natural killer cell proliferation and cytotoxic activity. Cell Transplant 20: pp. 681-691 CrossRef
  28. Kurschus, FC, Bruno, R, Fellows, E, Falk, CS, Jenne, DE (2005) Membrane receptors are not required to deliver granzyme B during killer cell attack. Blood 105: pp. 2049-2058 CrossRef
  29. Magness, ST, Bataller, R, Yang, L, Brenner, DA (2004) A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology 40: pp. 1151-1159 CrossRef
  30. Zhang, Z, Zhang, S, Zou, Z, Shi, J, Zhao, J, Fan, R, Qin, E, Li, B, Li, Z, Xu, X, Fu, J, Zhang, J, Gao, B, Tian, Z, Wang, FS (2011) Hypercytolytic activity of hepatic natural killer cells correlates with liver injury in chronic hepatitis B patients. Hepatology 53: pp. 73-85 CrossRef
  31. Jeong, WI, Park, O, Suh, YG, Byun, JS, Park, SY, Choi, E, Kim, JK, Ko, H, Wang, H, Miller, AM, Gao, B (2011) Suppression of innate immunity (natural killer cell/interferon-gamma) in the advanced stages of liver fibrosis in mice. Hepatology 53: pp. 1342-1351 CrossRef
  32. Luo, D, Vanderkerken, K, Chen, MC, Vermijlen, D, Asosingh, K, Willems, E, Triantis, V, Eizirik, DL, Kuppen, PJ, Wisse, E (2001) Rat hepatic natural killer cells (pit cells) express mRNA and protein similar to in vitro interleukin-2 activated spleen natural killer cells. Cell Immunol 210: pp. 41-48 CrossRef
  33. Smith, TJ (2005) Insights into the role of fibroblasts in human autoimmune diseases. Clin Exp Immunol 141: pp. 388-397 CrossRef
  34. Zhang, M, Wang, FL, Zhu, JY, Zheng, YB, Zhao, QY, Gu, YR, Zhang, Q, Chong, YT, Gao, ZL (2013) Liver myofibroblasts regulate the phenotype and function of monocytes through soluble factors in cirrhosis. Exp Ther Med 5: pp. 143-149
  35. Radaeva, S, Sun, R, Jaruga, B, Nguyen, VT, Tian, Z, Gao, B (2006) Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology 130: pp. 435-452 CrossRef
  36. Melhem, A, Muhanna, N, Bishara, A, Alvarez, CE, Ilan, Y, Bishara, T, Horani, A, Nassar, M, Friedman, SL, Safadi, R (2006) Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC. J Hepatol 45: pp. 60-71 CrossRef
  37. Jeong, WI, Park, O, Radaeva, S, Gao, B (2006) STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity. Hepatology 44: pp. 1441-1451 CrossRef
  38. Tian, Z, Chen, Y, Gao, B (2013) Natural killer cells in liver disease. Hepatology 57: pp. 1654-1662 CrossRef
  39. Zhang, DY, Friedman, SL (2012) Fibrosis-dependent mechanisms of hepatocarcinogenesis. Hepatology 56: pp. 769-775 CrossRef
  40. Hirofuji, H, Kakumu, S, Fuji, A, Ohtani, Y, Murase, K, Tahara, H (1987) Natural killer and activated killer activities in chronic liver disease and hepatocellular carcinoma: evidence for a decreased lymphokine-induced activity of effector cells. Clin Exp Immunol 68: pp. 348-356
  41. Notas, G, Kisseleva, T, Brenner, D (2009) NK and NKT cells in liver injury and fibrosis. Clin Immunol 130: pp. 16-26 CrossRef
  42. Sass, DA, Shakil, AO (2005) Fulminant hepatic failure. Liver Transpl 11: pp. 594-605 CrossRef
  43. Bourbonnais, E, Raymond, VA, Ethier, C, Nguyen, BN, El-Leil, MS, Meloche, S, Bilodeau, M (2012) Liver fibrosis protects mice from acute hepatocellular injury. Gastroenterology 14: pp. 130-139 CrossRef
  44. Zhang, Z, Zou, ZS, Fu, JL, Cai, L, Jin, L, Liu, YJ, Wang, FS (2008) Severe dendritic cell perturbation is actively involved in the pathogenesis of acute-on-chronic hepatitis B liver failure. J Hepatol 49: pp. 396-406 CrossRef
  45. Terme, M, Ullrich, E, Delahaye, NF, Chaput, N, Zitvogel, L (2008) Natural killer cell-directed therapies: moving from unexpected results to successful strategies. Nat Immunol 9: pp. 486-494 CrossRef
  
• 刊物主题：Biomedicine general; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1479-5876

文摘

Background Natural killer (NK) cells are abundant in the liver and constitute a major innate immune component that contributes to immune-mediated liver injury. However, few studies have investigated the phenotypes and functions of NK cells involved in hepatitis B related liver failure (LF), and the precise mechanism underlying NK cell regulation is not fully understood. Methods We detected the percentage and function of peripheral NK cells both in hepatitis B related LF patients and healthy volunteers by flow cytometry and isolated the liver myofibroblasts (LMFs) from hepatitis B related LF livers. To determine the possible effects of LMFs on NK cells, mixed cell cultures were established in vitro. Results We found a down-regulated percentage of peripheral NK cells in hepatitis B related LF patients, and their NK cells also displayed decreased activated natural cytotoxicity receptors (NCRs) and cytokine production. In a co-culture model, LMFs sharply attenuated IL-2-induced NK cell triggering receptors, cytotoxicity, and cytokine production. The inhibitory effect of LMFs on NK cells correlated with their ability to produce prostaglandin (PG) E2. Conclusion These data suggest that LMFs may protect against immune-mediated liver injury in hepatitis B related LF patients by inhibiting NK cell function via PGE2.