Moderne Diagnoseverfahren in der Dermatoonkologie

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• 作者：Dr. C. Kellner (1)
  U. Reinhold (1)
  
  1. Dermatologisches Zentrum Bonn ; Friedensplatz ; Friedensplatz 16 ; 53111 ; Bonn ; Deutschland
  
• 关键词：Konfokale Laserscanmikroskopie ; Optische Koh盲renztomographie ; Elektronische Impedanzspektroskopie ; Multispektralanalyse ; Verlaufskontrollen ; Confocal laser scanning microscopy ; Optical coherence tomography ; Electrical impedance spectroscopy ; Multispectral analysis ; Follow ; up
• 刊名：Der Pathologe
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：36
• 期：1
• 页码：11-15
• 全文大小：500 KB
• 参考文献：1. Aberg P, Birgersson U, Elsner P et al (2011) Electrical impedance spectroscopy and the diagnostic accuracy for malignant melanoma. Exp Dermatol 20(8):648鈥?52. doi:10.1111/j.1600-0625.2011.01285.x (Epub 2011 May 4) CrossRef
  2. Abuzahra F, Sp枚ler F, F枚rst M et al (2010) Pilot study: optical coherence tomography as a non-invasive diagnostic perspective for real time visualisation of onychomycosis. Mycoses 53(4):334鈥?39. doi:10.1111/j.1439-0507.2009.01717.x (Epub 2009 Sep 28)
  3. Banzhaf CA, Themstrup L, Ring HC et al (2014) Optical coherence tomography imaging of non-melanoma skin cancer undergoing imiquimod therapy. Skin Res Technol 20(2):170鈥?76. doi:10.1111/srt.12102 (Epub 2013 Sep 16) CrossRef
  4. Banzhaf CA, Themstrup L, Ring HC et al (2013) In vivo imaging of Sarcoptes scabiei infestation using optical coherence tomography. Case Rep Dermatol 5(2):156鈥?62. doi:10.1159/000352066 CrossRef
  5. Coleman AJ, Richardson TJ, Orchard G et al (2013) Histological correlates of optical coherence tomography in non-melanoma skin cancer. Skin Res Technol 19(1):10鈥?9. doi:10.1111/j.1600-0846.2012.00626.x (Epub 2012 Jun 28) CrossRef
  6. Fercher AF, Hitzenberger CK, Drexler W et al (1993) In vivo optical coherence tomography. Am J Ophtalmol 116:113鈥?14 CrossRef
  7. Fercher AF, Mengedoht K, Werner W (1988) Eye-length measurement by interferometry with partially coherent light. Opt Lett 13:186鈥?88 CrossRef
  8. Gambichler T, Jaedicke V, Terras S (2011) Optical coherence tomography in dermatology: technical and clinical aspects. Arch Dermatol Res 303:457鈥?73 CrossRef
  9. Gerger A, Koller S, Weger W et al (2006) Sensitivity and specificity of confocal laser-scanning microscopy for in vivo diagnosis of malignant skin tumors. Cancer 107:193鈥?00 CrossRef
  10. Guitera P et al (2013) Improving management and patient care in Lentigo maligna by mapping with in vivo confocal microscopy. JAMA Dermatol 149(6):692鈥?98 CrossRef
  11. Guitera P, Menzies SW, Longo C et al (2012) In vivo confocal microscopy for diagnosis of melanoma and basal cell carcinoma using a two-step method: analysis of 710 consecutive clinically equivocal cases. J Invest Dermatol 132:2386鈥?394 CrossRef
  12. Guitera P, Pellacani G, Crotty KA et al (2010) The impact of in vivo reflectance confocal microscopy on the diagnostic accuracy of lentigo maligna and equivocal pigmented and nonpigmented macules of the face. J Invest Dermatol 130(8):2080鈥?091 CrossRef
  13. Gutkowicz-Krusin D, Elbaum M, Jacobs A et al (2000) Precision of automatic measurements of pigmented skin lesion parameters with a MelaFind(TM) multispectral digital dermoscope. Melanoma Res 10(6):563鈥?70 CrossRef
  14. Halpern A, Rajadhyaksha M, Toledo-Crow R (2005) Bringing histology to the bedside. J Invest Dermatol 124:8鈥?0
  15. Hinz T, Ehler LK, Hornung T et al (2012) Preoperative characterization of Basal cell carcinoma comparing tumour thickness measurement by optical coherence tomography, 20-MHz ultrasound and histopathology. Acta Derm Venereol 92(2):132鈥?37 CrossRef
  16. http://www.awmf.org/uploads/tx_szleitlinien/013-076l_S1_Konfokale_Lasermikroskopie_2011-07_01.pdf
  17. http://www.melafind.de/wp-content/uploads/M100-BR-005RevA-_PhysDetail_f_rev_lowres.pdf
  18. http://www.octnews.org/articles/5178489/michelson-diagnostics-to-launch-enhanced-software-/
  19. Huang D, Swanson EA, Lin CP et al (1991) Optical coherence tomography. Science 254:1178鈥?181 CrossRef
  20. Huzaira M, Rius F, Rajadhyaksha M et al (2001) Topogtaphic variations in normal skin, as viewed by in vivo reflectance confocal microscopy. J Invest Dermatol 116(6):846鈥?52 CrossRef
  21. Langeey RG, Burton E, Walsh N et al (2006) In vivo confocal scanning lasaer microscopy of benign letnigines: comparisonto conventional histology and in vivo characteristics of lentigo maligna. J Am Acad Dermatol 55:88鈥?7 CrossRef
  22. Maier T, Braun-Falco M, Hinz T et al (2012) Morphology of basal cell carcinoma in high definition optical coherence tomography: en-face and slice imaging mode, and comparison with histology. J Eur Acad Dermatol Venereol. doi:10.1111/j.1468-3083.2012.04551.x (Epub ahead of print)
  23. Mogensen M, Jaergensen TM, Nurnberg BM et al (2009) Assessment of optical coherence tomography imaging in the diagnosis of non-melanoma skin cancer and benign lesions versus normal skin: observer-blinded evaluation by dermatologists and pathologists. Dermatol Surg 35(6):965鈥?72 CrossRef
  24. Mohr P, Birgersson U, Berking C et al (2013) Electrical impedance spectroscopy as a potential adjunct diagnostic tool for cutaneous melanoma. Skin Res Technol 19(2):75鈥?3. doi:10.1111/srt.12008 (Epub 2013 Jan 27) CrossRef
  25. Monheit G, Cognetta AB, Ferris L et al (2011) The performance of MelaFind: a prospective multicenter study. Arch Dermatol 147(2):188鈥?94 CrossRef
  26. Nori S, Rius-D铆az F, Cuevas J et al (2004) Sensitivity and specificity of reflectance-mode confocal microscopy for in vivo diagnosis of basal cell carcinoma: a multicenter study. J Am Acad Dermatol 51:923鈥?30 CrossRef
  27. Pellacani G, Cesinaro A, Seidenari S (2005) Reflectance-mode confocal microscopy of pigmented skin lesions 鈥?improvement in melanoma diagnostic specificity. J Am Acad Dermatol 53(6):979鈥?85 CrossRef
  28. Pellacani G, Guitera P, Longo C et al (2007) The impact of in vivo reflectance confocal microscopy for the diagnostic accuracy of melanoma and equivocal melanocytic lesions. J Invest Dermatol. doi:10.1038/sj.jid.5700993
  29. Pellacani G, Longo C, Malvehy J et al (2008) In vivo confocal microscopic and histopathologic correlations of dermoscopic features in 202 melanocytic lesions. Arch Dermatol 144(12):1597鈥?608 CrossRef
  30. Rajadhyaksha M, Gonzalez S, Zavislan JM et al (1999) In vivo confocal laser microscopy of human skin II: advances in instrumentation and comparison with histology. J Invest Dermatol 113:293鈥?03 CrossRef
  31. Rajadhyaksha M, Grossman M, Esterowitz D et al (1995) In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. J Invest Dermatol 104:946鈥?52 CrossRef
  32. Hofmann-Wellenhof R, Pellacani G, Malvehy J, Soyer HP (Hrsg) (2012) Reflectance confocal microscopy for skin diseases. Springer, Berlin Heidelberg New York
  33. Gonz谩lez S, Gill M, Halpern AC (Hrsg) (2008) Reflectance confocal microscopy of cutaneous tumors, an atlas with clinical, dermoscopic and histological correlations. informa healthcare, London
  34. Rothmund G, Sattler EC, Kaestle R et al (2013) Confocal laser scanning microscopy as a new valuable tool in the diagnosis of onychomycosis 鈥?comparison of six diagnostic methods. Mycoses 56(1):47鈥?5. doi:10.1111/j.1439-0507.2012.02198.x (Epub 2012 Apr 23) CrossRef
  35. Sattler E et al (2012) How long does protection last? 鈥?in vivo fluorescence confocal laser scanning imaging fort he evaluation of the kincetics of a topically applied lotion in an everyday setting. Skin Res Technol 18(3):370鈥?77 CrossRef
  36. Schmitz L, Reinhold U, Bierhoff E, Dirschka T (2013) Optical coherence tomography: its role in daily dermatological practice. J Dtsch Dermatol Ges 11(6):499鈥?07. doi:10.1111/ddg.12073 (Epub 2013 Apr 9)
  37. Wells R, Gutkowicz-Krusin D, Veledar E et al (2012) Comparison of diagnostic and management sensitivity to melanoma between dermatologists and MelaFind: a pilot study. Arch Dermatol 148(9):1083鈥?084 CrossRef
  38. Welzel J, Lankenau E, Birngruber R, Engelhardt R (1997) Optical coherence tomography of the human skin. J Am Acad Dermatol 37:958鈥?63 CrossRef
  39. Welzel J (2001) Optical coherence tomography in dermatology: a review. Skin Res Technol 7:1鈥? CrossRef
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pathology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1963

文摘

Background New technologies, such as confocal laser scanning microscopy (CLSM), optical coherence tomography (OCT), electrical impedance spectroscopy (EIS) and multispectral analysis have greatly enriched the possibilities of diagnostics in dermatological oncology. They can be supplementary tools to dermatoscopy and histopathology to make a more precise diagnosis of skin lesions. Objectives Increasing relevance of new systems for diagnosis and monitoring of dermatological therapy. Presentation of the technology and the diagnostic range of application for various skin lesions. Material and methods Presentation of scientifically relevant studies and statistical data, discussion of basic research and expert recommendations. Results The diagnostic spectrum of dermatological oncology has been significantly enriched in recent years. New technologies, such as CLSM, OCT, EIS and multispectral analysis are non-invasive and therefore painless for the patient. In only a few minutes these techniques deliver valid data and findings and provide dermatologists with more accurate diagnostic information about benign or malignant melanocytic skin lesions or the various forms of white skin cancer. Conclusion In recent years, non-invasive diagnostic and analytical imaging procedures have been progressively established in dermatological oncology and supplement classical dermatoscopy and histopathology. With respect to the follow-up of different therapeutic modalities unnecessary tissue biopsies and scars can be reduced for patients.