Candida albicans phospholipomannan: a sweet spot for controlling host response/inflammation
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- 作者：Chantal Fradin (1) (2)
Emerson Soares Bernardes (3)
Thierry Jouault (1) (2) (4)
1. Inserm U995 ; 59000 ; Lille ; France
2. Universit茅 de Lille ; 59000 ; Lille ; France
3. Institute of Energy and Nuclear Research (IPEN) ; S茫o Paulo ; Brazil
4. Facult茅 de M茅decine H. Warembourg ; P么le Recherche ; Place Verdun ; Cedex ; 59037 ; Lille ; France - 关键词：Glycosphingolipids ; Inflammatory response ; Regulation ; Yeasts
- 刊名：Springer Seminars in Immunopathology
- 出版年：2015
- 出版时间：March 2015
- 年：2015
- 卷：37
- 期：2
- 页码：123-130
- 全文大小：1,256 KB
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- 刊物主题：Biomedicine
Immunology
Internal Medicine - 出版者：Springer Berlin / Heidelberg
- ISSN：1863-2300
文摘
Fungal cell walls contain several types of glycans, which play important roles in the pathogenesis of fungal infection and host immune response. Among them, glycosphingolipids have attracted much attention lately since they contribute actively to the fungi development and fungal-induced pathogenesis. Although glycosphingolipids are present in pathogenic and non-pathogenic fungi, pathogenic strains exhibit distinct glycan structures on their sphingolipids, which contribute to the regulatory processes engaged in inflammatory response. In Candida albicans, phospholipomannan (PLM) represents a prototype of these sphingolipids. Through its glycan and lipid moieties, PLM induces activation of host signaling pathways involved in the initial recognition of fungi, causing immune system disorder and persistent fungal disease. In this review, first we describe the general aspects of C. albicans sphingolipids synthesis with a special emphasize on PLM synthesis and its insertion into the cell wall. Then, we discuss the role of PLM glycosylation in regulating immune system activation and its contribution to the chronic persistent inflammation found in Candida infections and chronic inflammatory diseases.