Meta-analysis of the relationship between single nucleotide polymorphism rs72689236 of caspase-3 and Kawasaki disease

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• 作者：Yanlin Xing ; Hong Wang ; Xiaomei Liu ; Xianyi Yu ; Rui Chen…
• 关键词：Kawasaki disease ; Case–control study ; Rs72689236 ; Polymorphism ; Meta ; analysis
• 刊名：Molecular Biology Reports
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：41
• 期：10
• 页码：6377-6381
• 全文大小：189 KB
• 参考文献：1. Onouchi Y, Gunji T, Burns JC et al (2007) ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nat Genet 40:35-2 CrossRef
  2. Kuo H-C, Yang KD, Juo S-HH et al (2011) ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population. PLoS ONE 6:e17370 CrossRef
  3. Jhang WK, Kang M-J, Jin H-S et al (2009) The CCR5 (?135C/T) polymorphism may be associated with the development of Kawasaki disease in Korean children. J Clin Immunol 29:22-8 CrossRef
  4. Huang YC, Lin YJ, Chang JS et al (2010) Single nucleotide polymorphism rs2229634 in the ITPR3 gene is associated with the risk of developing coronary artery aneurysm in children with Kawasaki disease. Int J Immunogenet 37:439-43 CrossRef
  5. Jin H-S, Kim HB, Kim BS et al (2007) The IL-10 (?27 A/C) promoter polymorphism may be associated with coronary aneurysms and low serum albumin in Korean children with Kawasaki disease. Pediatr Res 61:584-87 CrossRef
  6. Chi H, Huang F-Y, Chen M-R et al (2010) ITPKC gene SNP rs28493229 and Kawasaki disease in Taiwanese children. Hum Mol Genet 19:1147-151 CrossRef
  7. Ha K-S, Jang G, Lee J, Lee K, Hong Y, Son C, Lee J (2013) Incomplete clinical manifestation as a risk factor for coronary artery abnormalities in Kawasaki disease: a meta-analysis. Eur J Pediatr 172:343-49 CrossRef
  8. Onouchi Y, Ozaki K, Buns JC et al (2010) Common variants in CASP3 confer susceptibility to Kawasaki disease. Hum Mol Genet 19:2898-906 CrossRef
  9. Soung YH, Lee JW, Kim SY et al (2004) Somatic mutations of CASP3 gene in human cancers. Hum Genet 115:112-15 CrossRef
  10. Kuo H-C, Yu H-R, Juo S-HH et al (2010) CASP3 gene single-nucleotide polymorphism (rs72689236) and Kawasaki disease in Taiwanese children. J Hum Genet 56:161-65 CrossRef
  11. Onouchi Y, Suzuki Y, Suzuki H et al (2013) ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease. Pharmacogenomics J 13:52-9 CrossRef
  12. Deeks JJ, Altman DG, Bradburn MJ (2001) Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In: Egger M, Davey-Smith G, Altman DG (eds) Systematic reviews in health care: Meta / -analysis in context, 2nd edn. BMJ Books, London, pp 285-12 CrossRef
  13. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. Br Med J 327:557 CrossRef
  14. Mantel N, Haenszel W (2004) Statistical aspects of the analysis of data from retrospective studies of disease. Chall Epidemiol 1:533-53
  15. Dersimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177-88 CrossRef
  16. Egger M, Smith GD, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. Br Med J 315:629-34 CrossRef
  17. Peng Q, Chen C, Wu Q et al (2013) Association of CASP3 gene single nucleotide polymorphisms with Kawasaki disease in Chinese children patients. Zhonghua yi xue yi chuan xue za zhi 30:180-84
  18. Wei Chen H-YZ, Shu-Xiang Lin (2013) Association of CASP3 gene polymorphism with Kawasaki disease susceptibility and coronary artery lesion. Shandong Med J 53:20-4
  19. Huang WC, Huang LM, Chang IS et al (2009) Epidemiologic features of Kawasaki disease in Taiwan, 2003-006. Pediatrics 123:e401–e405 CrossRef
  20. Nakamura Y, Yashiro M, Uehara R, Oki I, Kayaba K, Yanagawa H (2008) Increasing incidence of Kawasaki disease in Japan: nationwide survey. Pediatr Int 50:287-90 CrossRef
  21. Peng Q, Chen CH, Wu Q, Yang Y (2013) Association of new functional SNP rs72689236 of CASP3 with Kawasaki disease: a meta-analysis. Zhongguo Dang Dai Er Ke Za Zhi 15:477-83
  22. Kuo HC, Chang WC (2011) Genetic polymorphisms in Kawasaki disease. Acta Pharmacol Sin 32:1193-198 CrossRef
  23. Hirota J, Furuichi T, Mikoshiba K (1999) Inositol 1, 4, 5-trisphosphate receptor type 1 is a substrate for caspase-3 and is cleaved during apoptosis in a caspase-3-dependent manner. J Biol Chem 274:34433-4437 CrossRef
  
• 作者单位：Yanlin Xing (1)
  Hong Wang (1)
  Xiaomei Liu (2)
  Xianyi Yu (1)
  Rui Chen (1)
  Ce Wang (1)
  Xuexin Yu (1)
  Le Sun (1)
  
  1. Department of Pediatrics, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning, China
  2. Experimental research center, Shengjing Hospital of China Medical University, Shenyang, 110004, China
  
• ISSN：1573-4978

文摘

Kawasaki disease is a pediatric systemic vasculitis of unknown etiology, for which a genetic influence is suspected. But whether single nucleotide polymorphism (SNP) of caspase-3 rs72689236 is associated with Kawasaki disease is controversial. The aim of our study is to assess the association between the SNP of caspase-3 and risk for Kawasaki disease. We searched PubMed, MEDLINE, EMBASE, Springer, Elsevier Science Direct, Cochrane Library Google scholar, CNKI (China National Knowledge Infrastructure, in Chinese) and Wanfang database (in Chinese) to identify studies investigating the association between rs72689236 polymorphism and Kawasaki disease occurrence. There were five eligible studies, which included 4,241 (case group 1,560; control group 2,681) participants in this meta-analysis. Pooled odds ratios (ORs) and 95?% confidence intervals (95?% CIs) were calculated in a fixed-effects model (the Mantel–Haenszel method) or a random-effects model (the DerSimonian and Laird method) when appropriate. Significant associations were found under the overall ORs for A-allele comparison (A vs. G, pooled OR 1.33, 95?% CI 1.21-.46), AA versus GG comparison (pooled OR 1.64, 95?% CI 1.35-.00), GA versus GG comparison (pooled OR 1.42, 95?% CI 1.24-.63), recessive model (AA vs. GG?+?GA, pooled OR 1.37, 95?% CI 1.15-.64) and dominant model (AA?+?GA vs. GG, pooled OR 1.47, 95?% CI 1.29-.67). This meta-analysis suggested that SNP rs72689236 of caspase-3 might be associated with susceptibility of Kawasaki disease and the allele A might increase the risk of Kawasaki disease in Asian samples such as Japanese and Chinese. In addition, individual studies with large sample size are needed to further evaluate the associations in various ethnic populations.