Pigment epithelium-derived factor alleviates endothelial injury by inhibiting Wnt/β-catenin pathway

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• 作者：Shouyuan Ma ; Shutong Yao ; Hua Tian ; Peng Jiao ; Nana Yang&#8230
• 关键词：Pigment epithelium ; derived factor ; Endothelial injury ; Wnt/β ; catenin pathway ; Atherosclerosis ; Oxidative stress ; Oxidized low ; density lipoprotein
• 刊名：Lipids in Health and Disease
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：16
• 期：1
• 全文大小：2918KB
• 刊物主题：Lipidology; Medical Biochemistry; Clinical Nutrition;
• 出版者：BioMed Central
• ISSN：1476-511X
• 卷排序：16

文摘

BackgroundOxidized low-density lipoprotein (ox-LDL) can induce endothelial injury and plays a vital role in the procession and development of atherosclerosis. Little is known regarding whether Wnt/β-catenin pathway is involved in ox-LDL-induced endothelial injury or whether it further promotes atherosclerosis via increased oxidative stress. This study aimed to investigate the role of Wnt/β-catenin pathway in ox-LDL-induced vascular endothelial injury and determine whether pigment epithelium-derived factor (PEDF) could alleviate ox-LDL-induced endothelial injury by inhibiting Wnt/β-catenin pathway.