During development intense Sox2 expression marks not only Prox1-expressing taste bud cell but also perigemmal cell lineages

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• 作者：Ayumi Nakayama (1) (2)
  Hirohito Miura (1)
  Makoto Ooki (1)
  Shuitsu Harada (1)
  
  1. Oral Physiology ; Kagoshima University Graduate School of Medical and Dental Sciences ; 8-35-1 Sakuragaoka ; Kagoshima-shi ; Kagoshima ; 890-8544 ; Japan
  2. General Dental Practices ; Kagoshima University Medical and Dental Hospital ; 8-35-1 Sakuragaoka ; Kagoshima-shi ; Kagoshima ; 890-8520 ; Japan
  
• 关键词：Taste bud ; Primordia ; Circumvallate ; Fungiform ; Soft palate
• 刊名：Cell and Tissue Research
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：359
• 期：3
• 页码：743-753
• 全文大小：1,880 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Proteomics
  Molecular Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0878

文摘

Sox2 is proposed to regulate the differentiation of bipotential progenitor cells into taste bud cells. However, detailed expression of Sox2 remains unclear. In this report, Sox2 expression during taste bud development in the fungiform (FF), circumvallate (CV) and soft palate (SP) areas is examined together with Prox1. First, we immunohistochemically checked Prox1 expression in adults and found that almost all taste bud cells are Prox1-positive. During FF development, intense Sox2 expression was restricted to taste bud primordia expressing Prox1 at E12.5. However, at E14.5, Sox2 was intensely expressed outside the developing taste buds resolving to perigemmal Sox2 expression in adults. In the SP, at E14.5, taste bud primordia emerged as Prox1-expressing cell clusters. However, intense Sox2 expression was not restricted to taste bud primordia but was detected widely in the epithelium. During development, Sox2 expression outside developing taste buds was generally down-regulated but was retained in the perigemmal region similarly to that in the FF. In the CV, the initial stage of taste bud development remained unclear because of the lack of taste bud primordia comparable to that in the FF and SP. Here, we show that Prox1-expressing cells appear in the apical epithelium at E12.5, in the inner trench wall at E17.5 and in the outer trench wall at E18.5. Sox2 was again not restricted to developing taste bud cells expressing Prox1 during CV development. The expression patterns support that Sox2 does not serve as a cell fate selector between taste bud cells and surrounding keratinocytes but rather may contribute to them both.