Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

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• 作者：Eiji Matsuura (1)
  Akiko Yoshimura (1)
  Satoshi Nozuma (1)
  Itsuro Higuchi (2)
  Ryuji Kubota (3)
  Hiroshi Takashima (1)
  
  1. Department of Neurology and Geriatrics ; Kagoshima University Graduate School of Medical and Dental Sciences ; 8-35-1 Sakuragaoka ; Kagoshima ; 890-8520 ; Japan
  2. School of Health Sciences ; Faculty of Medicine ; Kagoshima University ; 8-35-1 Sakuragaoka ; Kagoshima ; 890-8520 ; Japan
  3. Center for Chronic Viral Diseases ; Kagoshima University Graduate School of Medical and Dental Sciences ; 8-35-1 Sakuragaoka ; Kagoshima ; 890-8520 ; Japan
  
• 关键词：Axial myopathy ; HTLV ; 1 ; HAM/TSP ; Paraspinal muscle
• 刊名：BMC Neurology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：15
• 期：1
• 全文大小：936 KB
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• 刊物主题：Neurology; Neurochemistry; Neurosurgery;
• 出版者：BioMed Central
• ISSN：1471-2377

文摘

Background The clinical features of myositis related with Human T-cell leukemia virus type 1 (HTLV-1) remains unclear despite epidemiological studies suggesting inflammatory myopathy associated with the virus. Case presentation Here, we described the clinical presentations, muscle biopsy studies and laboratory results of two siblings with HTLV-1-associated myelopathy / tropical spastic paraparesis (HAM/TSP) who were affected with lumbar lordosis. Computed tomography (CT) scans demonstrated marked paraspinal muscle atrophy in both patients. Immunohistochemical studies of biopsy tissue obtained from one of the patients revealed inflammatory change of the muscle. Upon oral prednisolone therapy, the patient showed improvement in muscle strength and serum creatine kinase (CK) level. Conclusion Myopathy or specifically axial myopathy should be considered as clinical symptom when treating the patients with HTLV-1 infection.