Probiotics during weaning: a follow-up study on effects on body composition and metabolic markers at school age

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• 作者：Frida Karlsson Videhult ; Inger ?hlund ; Hans Stenlund…
• 关键词：Probiotic ; Lactobacillus paracasei ssp. paracasei F19 ; Overweight ; Long ; term effects ; Children
• 刊名：European Journal of Nutrition
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：54
• 期：3
• 页码：355-363
• 全文大小：262 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1436-6215

文摘

Purpose An aberrant gut microbiome has been suggested to contribute to the worldwide epidemic of obesity. In animal models, the probiotic Lactobacillus paracasei ssp. paracasei F19 (LF19)?induced upregulation of genes involved in energy homoeostasis, reduced body fat and altered the serum (S) lipoprotein profile. In our previous report, feeding LF19 to infants during weaning impacted the global plasma metabolome. LF19 lowered palmitoleic acid, a monounsaturated fatty acid associated with hypertriglyceridemia and increased visceral adiposity. Therefore, we assessed if feeding LF19 from 4 to 13?months of age would have long-term effects on body composition, growth and metabolic markers. Methods Of 179 children included in our baseline study, 120 entered the follow-up at 8-?years of age, n?=?58 in the probiotic and n?=?62 in the placebo group. Body composition was measured using dual energy X-ray absorptiometry. Anthropometrics of the child and accompanying parent(s) were assessed. S-lipids, insulin, glucose and transaminases were determined after overnight fasting. Results LF19 did not affect body mass index z-score, sagittal abdominal diameter, fat-free mass, fat mass index, truncal fat %, android or gynoid fat % and had no long-term impact on any of the assessed metabolic markers (p?>?0.05). Conclusion Feeding LF19 during infancy did not modulate body composition, growth or any of the assessed metabolic markers at school age. The steady increase in probiotic products targeting infants and children calls for long-term follow-up of initiated probiotic intervention studies.