Association of Resistin with Insulin Resistance and Factors of Metabolic Syndrome in North Indians

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• 作者：Arun Kumar Singh ; Sunita Tiwari ; Abhishek Gupta…
• 关键词：Resistin ; Metabolic syndrome ; Insulin resistance ; Triglyceride ; Insulin ; Waist circumference
• 刊名：Indian Journal of Clinical Biochemistry
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：30
• 期：3
• 页码：255-262
• 全文大小：1,648 KB
• 参考文献：1.Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409:307-2.PubMed View Article
  2.Steppan CM, Lazar MA. Resistin and obesity-associated insulin resistance. Trends Endocrinol Metab. 2002;1:18-3.View Article
  3.Juan CC, Au LC, Fang VS, Kang SF, Ko YH, Kuo SF, et al. Suppressed gene expression of adipocyte resistin in an insulin-resistant rat model probably by elevated free fatty acids. Biochem Biophys Res Commun. 2001;289:1328-3.PubMed View Article
  4.Le Lay S, Boucher J, Rey A, Castan-Laurell I, Krief S, Ferre P. Decreased resistin expression in mice with different sensitivities to a high-fat diet. Biochem Biophys Res Commun. 2001;289:564-.PubMed View Article
  5.Ukkola O. Resistin—a mediator of obesity-associated insulin resistance or an innocent bystander? Eur J Endocrinol. 2002;147:571-.PubMed View Article
  6.Palanivel R, Maida A, Liu Y, Sweeney G. Regulation of insulin signalling, glucose uptake and metabolism in rat skeletal muscle cells upon prolonged exposure to resistin. Diabetologia. 2006;1:183-0.View Article
  7.Kim KH, Lee K, Moon YS, Sul HS. A cysteine-rich adipose tissue specific secretory factor inhibits adipocyte differentiation. J Biol Chem. 2001;14:11252-.View Article
  8.Qi Q, Wang J, Li H, Yu Z, Ye X, Hu FB. Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese. Eur J Endocrinol. 2008;159:585-3.PubMed View Article
  9.Sharma P, Mishra S. Metabolic syndrome: early identification prevents type II diabetes and cardiovascular disease. Indian J Clin Biochem. 2007;22(1):1-.PubMed Central PubMed View Article
  10.Won JC, Park CY, Lee WY, Lee ES, Oh SW, Park SW. Association of plasma levels of resistin with subcutaneous fat mass and markers of inflammation but not with metabolic determinants or insulin resistance. J Korean Med Sci. 2009;24:695-00.PubMed Central PubMed View Article
  11.Sinorita H, Asdie RH, Pramono RB, Purnama LB, Asdie AH. Leptin, Adiponectin and Resistin concentration in obesity class I and II at Sardjito Hospital Yogyakarta. Acta Med Indones. 2010;42:74-.PubMed
  12.Wasim H, Al-Daghri NM, Chetty R, McTernan PG, Barnett AH, Kumar S. Relationship of serum adiponectin and resistin to glucose intolerance and fat topography in South-Asians. Cardiovasc Diabetol. 2006;2:5-0.
  13.Degawa-Yamauchi M, Bovenkerk JE, Juliar BE, Watson W, Kerr K, Jones R, et al. Serum resistin (FIZZ3) protein is increased in obese humans. J Clin Endocrinol Metab. 2003;11:5452-.View Article
  14.Heilbronn LK, Rood J, Janderova L, Albu JB, Kelley DE, Ravussin E, et al. Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects. J Clin Endocrinol Metab. 2004;4:1844-.View Article
  15.Pagano C, Marin O, Calcagno A, Schiappelli P, Pilon C, Milan G, et al. Increased plasma resistin in adults with Prader–Willi syndrome is related to obesity and not to insulin resistance. J Clin Endocrinol Metab. 2005;90:4335-0.PubMed View Article
  16.Matsuda M, Kawasaki F, Yamada K, Kanda Y, Saito M, Eto M, et al. Impact of adiposity and plasma adipocytokines on diabetic angiopathies in Japanese type 2 diabetic subjects. Diabet Med. 2004;21:881-.PubMed View Article
  17.Utzschneider KM, Carr DB, Tong J, Wallace TM, Hull RL, Zraika S, et al. Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans. Diabetologia. 2005;48:2330-.PubMed View Article
  18.Filippidis G, Liakopoulos V, Mertens PR, Kiropoulos T, Stakias N, Verikouki C, et al. Resistin serum levels are increased but not correlated with insulin resistance in chronic hemodialysis patients. Blood Purif. 2005;23:421-.PubMed View Article
  19.Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002;288:2709-6.PubMed View Article
  20.Ninomiya JK, L’Italien G, Criqui MH, Whyte JL, Gamst A, Chen RS. Association of the metabolic syndrome with history of myocardial infarction and stroke in the Third National Health and Nutrition Examination Survey. Circulation. 2004;109:42-.PubMed View Article
  21.Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program NCEP Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486-7.View Article
  22.Rajala MW, Obici S, Scherer PE, Rossetti L. Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. J Clin Invest. 2003;111:225-0.PubMed Central PubMed View Article
  23.El-Shal AS, Pasha HF. Association of resistin gene polymorphis
• 作者单位：Arun Kumar Singh (1)
  Sunita Tiwari (2)
  Abhishek Gupta (2)
  Kamla Kant Shukla (3)
  Kumar Gaurav Chhabra (4)
  Achileshwar Pandey (5)
  Aditya Bhushan Pant (6)
  
  1. Department of Biochemistry, DBDC & H, Muktsar, 152026, Punjab, India
  2. Department of Physiology, King George Medical University (KGMU), Lucknow, India
  3. Department of Biochemistry, King George Medical University (KGMU), Lucknow, India
  4. Department of Public Health Dentistry, DBDC & H, Muktsar, India
  5. Department of Physiology, Uttaranchal Dental College and Medical Research Institute, Uttaranchal, India
  6. In Vitro Toxicology Laboratory, IITR, Lucknow, India
  
• 刊物主题：Biochemistry, general; Microbiology; Chemistry/Food Science, general; Pathology;
• 出版者：Springer India
• ISSN：0974-0422

文摘

Metabolic syndrome (MetS) is a cluster of interrelated common clinical disorders. The role of resistin in insulin sensitivity and MetS is controversial till date. So, the aim of the present study was to investigate the relationship of plasma resistin levels with markers of the MetS in Indian subjects. In a case control study, total 528 subjects were selected for the study. 265 (194 male and 71 female) were cases (with MetS) and 263 (164 male and 99 female) were controls (without MetS). Required anthropometric measurements and calculations were carried out accordingly. All the Biochemical estimations were carried out according to standard protocol. Resistin level was measured by the standard protocol (By ELISA i.e. enzyme linked immunosorbent assay) as illustrated in the kit. Insulin level was also measured by the standard protocol as illustrated in the kit and insulin resistance was calculated by the standard procedures. Plasma resistin levels were significantly higher in cases compared with controls (male?=?13.05?±?4.31 vs. 7.04?±?2.09?ng/ml; p?≤?.001 and female?=?13.53?±?4.14 vs. 7.42?±?2.30?ng/ml; p?≤?.001). Plasma resistin levels were well correlated with waist circumference, glucose, triglycerides, waist/hip ratio, systolic and diastolic blood pressure, high density lipoprotein, total cholesterol, serum low density lipoprotein, serum very low density lipoprotein, insulin and insulin resistance. Plasma resistin levels were elevated in presence of the MetS and were associated with increased metabolic risk factors.