In vivo characterization of metabotropic glutamate receptor type 5 abnormalities in behavioral variant FTD
详细信息 查看全文
- 作者：Antoine Leuzy ; Eduardo Rigon Zimmer ; Jonathan Dubois…
- 关键词：Behavioral variant frontotemporal dementia ; Frontotemporal lobar degeneration ; Positron emission tomography ; 11C ; ABP688 ; Metabotropic glutamate receptor type 5 ; Excitotoxicity
- 刊名：Brain Structure and Function
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：221
- 期：3
- 页码：1387-1402
- 全文大小：7,401 KB
- 参考文献：Alladi S, Xuereb J, Bak T, Nestor P, Knibb J, Patterson K, Hodges JR (2007) Focal cortical presentations of Alzheimer’s disease. Brain J Neurol 130:2636–2645. doi:10.1093/brain/awm213 CrossRef
Ametamey SM, Kessler LJ, Honer M, Wyss MT, Buck A, Hintermann S, Auberson YP, Gasparini F, Schubiger PA (2006) Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5. J Nucl Med 47:698–705PubMed
Ametamey SM, Treyer V, Streffer J, Wyss MT, Schmidt M, Blagoev M, Hintermann S, Auberson Y, Gasparini F, Fischer UC, Buck A (2007) Human PET studies of metabotropic glutamate receptor subtype 5 with 11C-ABP688. J Nucl Med 48:247–252PubMed
Ashburner J, Friston KJ (2000) Voxel-based morphometry—the methods. NeuroImage 11:805–821. doi:10.1006/nimg.2000.0582 CrossRef PubMed
Balschun D, Zuschratter W, Wetzel W (2006) Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory. Neuroscience 142:691–702. doi:10.1016/j.neuroscience.2006.06.043 CrossRef PubMed
Cabello N, Gandía J, Bertarelli DC, Watanabe M, Lluís C, Franco R, Ferré S, Luján R, Ciruela F (2009) Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells. J Neurochem 109:1497–1507. doi:10.1111/j.1471-4159.2009.06078.x CrossRef PubMed PubMedCentral
Canela L, Fernández-Dueñas V, Albergaria C, Watanabe M, Lluís C, Mallol J, Canela EI, Franco R, Luján R, Ciruela F (2009) The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function. J Neurochem 111:555–567. doi:10.1111/j.1471-4159.2009.06348.x CrossRef PubMed
Changeux J-P, Edelstein SJ (2005) Allosteric mechanisms of signal transduction. Science 308:1424–1428. doi:10.1126/science.1108595 CrossRef PubMed
Choi H, Kim YK, Oh SW, Im HJ, Hwang do W, Kang H, Lee B, Lee YS, Jeong JM, Kim EE, Chung JK, Lee DS (2014) In vivo imaging of mGluR5 changes during epileptogenesis using [11C]ABP688 PET in pilocarpine-induced epilepsy rat model. PLoS One 9:e92765. doi:10.1371/journal.pone.0092765 CrossRef PubMed PubMedCentral
Collins DL, Evans AC (1997) Animal: validation and applications of non-linear registration-based segmentation. Int J Pattern Recogn Art Intell 11:1271–1294CrossRef
Collins DL, Zijendos AP, Barré WFC, Evans AC (1999) ANIMAL + INSECT: inproved cortical structure segmentation. In: Kuba A, Samal M, Todd-Pokropek A (eds) Lecture Notes in Computer Science. Springer-Verlag, Berlin, Heidelberg, pp 210–223
Comtat C, Sureau FC, Sibomana M, Hong IK, Sjoholm N, Trebossen R (2008) Image based resolution modeling for the HRRT OSEM reconstructions software. In: IEEE Nuclear Science Symposium Conference Record, pp 4120–4123
Costes N, Dagher A, Larcher K, Evans AC, Collins DL, Reilhac A (2009) Motion correction of multi-frame PET data in neuroreceptor mapping: simulation based validation. Neuroimage 47:1496–1505. doi:10.1016/j.neuroimage.2009.05.052 CrossRef PubMed
Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J (1994) The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 44:2308–2314CrossRef PubMed
Dalfo E, Albasanz JL, Rodriguez A, Martin M, Ferrer I (2005) Abnormal group I metabotropic glutamate receptor expression and signaling in the frontal cortex in Pick disease. J Neuropathol Exp Neurol 64:638–647CrossRef PubMed
DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, Nicholson AM, Finch NA, Flynn H, Adamson J, Kouri N, Wojtas A, Sengdy P, Hsiung GY, Karydas A, Seeley WW, Josephs KA, Coppola G, Geschwind DH, Wszolek ZK, Feldman H, Knopman DS, Petersen RC, Miller BL, Dickson DW, Boylan KB, Graff-Radford NR, Rademakers R (2011) Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron 72:245–256. doi:10.1016/j.neuron.2011.09.011 CrossRef PubMed PubMedCentral
Deschwanden A, Karolewicz B, Feyissa AM, Treyer V, Ametamey SM, Johayem A, Burger C, Auberson YP, Sovago J, Stockmeier CA, Buck A, Hasler G (2011) Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study. Am J Psychiatry 168:727–734. doi:10.1176/appi.ajp.2011.09111607 CrossRef PubMed PubMedCentral
Diehl-Schmid J, Grimmer T, Drzezga A, Bornschein S, Riemenschneider M, Förstl H, Schwaiger M, Kurz A (2007) Decline of cerebral glucose metabolism in frontotemporal dementia: a longitudinal 18F-FDG-PET-study. Neurobiol Aging 28:42–50. doi:10.1016/j.neurobiolaging.2005.11.002 CrossRef PubMed
Donnelly CJ, Zhang PW, Pham JT, Haeusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, Rigo F, Bennett CF, Blackshaw S, Sattler R, Rothstein JD (2013) RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention. Neuron 80:415–428. doi:10.1016/j.neuron.2013.10.015 CrossRef PubMed PubMedCentral
Double KL, Reyes S, Werry EL, Halliday GM (2010) Selective cell death in neurodegeneration: why are some neurons spared in vulnerable regions? Prog Neurobiol 92:316–329. doi:10.1016/j.pneurobio.2010.06.001 CrossRef PubMed
Elmenhorst D, Biagini M, Minuzzi L, Aliaga A, Massarweh G, Diksic M, Avoli M, Bauer A, Rosa-Neto P (2009) Evaluation of reference models for [11C]ABP688 targeting the metabotropic glutamate receptor 5 in rats-application to an epilepsy model. J Cerebr Blood Flow Metab 29:S71–S72
Elmenhorst D, Minuzzi L, Aliaga A, Rowley J, Massarweh G, Diksic M, Bauer A, Rosa-Neto P (2010) In vivo and in vitro validation of reference tissue models for the mGluR(5) ligand [(11)C]ABP688. J Cereb Blood Flow Metab 30:1538–1549. doi:10.1038/jcbfm.2010.65 CrossRef PubMed PubMedCentral
Ferraguti F, Shigemoto R (2006) Metabotropic glutamate receptors. Cell Tissue Res 326:483–504. doi:10.1007/s00441-006-0266-5 CrossRef PubMed
Ferrer I (1999) Neurons and their dendrites in frontotemporal dementia. Dement Geriatr Cogn Disord 10(Suppl 1):55–60. doi:10.1159/000051214 CrossRef PubMed
Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198CrossRef PubMed
Fonov VS, Evans AC, McKinstry RC, Almli CR, Collins DL (2009) Unbiased nonlinear average age-appropriate brain templates from birth to adulthood. NeuroImage 47:S102. doi:10.1016/S1053-8119(09)70884-5 CrossRef
Francis PT (2003) Glutamatergic systems in Alzheimer’s disease. Int J Geriatr Psychiatry 18:S15–S21. doi:10.1002/gps.934 CrossRef PubMed
Francis PT (2009) Altered glutamate neurotransmission and behaviour in dementia: evidence from studies of memantine. Curr Mol Pharmacol 2:77–82CrossRef PubMed
Goetz CG, Fahn S, Martinez-Martin P, Poewe W, Sampaio C, Stebbins GT, Stern MB, Tilley BC, Dodel R, Dubois B, Holloway R, Jankovic J, Kulisevsky J, Lang AE, Lees A, Leurgans S, LeWitt PA, Nyenhuis D, Olanow CW, Rascol O, Schrag A, Teresi JA, Van Hilten JJ, LaPelle N (2007) Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): process, format, and clinimetric testing plan. Mov Disord 22:41–47. doi:10.1002/mds.21198 CrossRef PubMed
Good CD, Scahill RI, Fox NC, Ashburner J, Friston KJ, Chan D, Crum WR, Rossor MN, Frackowiak RS (2002) Automatic differentiation of anatomical patterns in the human brain: validation with studies of degenerative dementias. Neuroimage 17:29–46CrossRef PubMed
Greve DN, Svarer C, Fisher PM, Feng L, Hansen AE, Baare W, Rosen B, Fischl B, Knudsen GM (2014) Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data. Neuroimage 92:225–236. doi:10.1016/j.neuroimage.2013.12.021 CrossRef PubMed PubMedCentral
Gunn RN, Lammertsma AA, Hume SP, Cunningham VJ (1997) Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. Neuroimage 6:279–287. doi:10.1006/nimg.1997.0303 CrossRef PubMed
Harkany T, Abrahám I, Timmerman W, Laskay G, Tóth B, Sasvári M, Kónya C, Sebens JB, Korf J, Nyakas C, Zarándi M, Soós K, Penke B, Luiten PG (2000) beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis. Eur J Neurosci 12:2735–2745CrossRef PubMed
Hornberger M, Wong S, Tan R, Irish M, Piguet O, Kril J, Hodges JR, Halliday G (2012) In vivo and post-mortem memory circuit integrity in frontotemporal dementia and Alzheimer’s disease. Brain 135:3015–3025. doi:10.1093/brain/aws239 CrossRef PubMed
Huber KM, Roder JC, Bear MF (2001) Chemical induction of mGluR5- and protein synthesis–dependent long-term depression in hippocampal area CA1. J Neurophysiol 86:321–325PubMed
Jeong Y, Cho SS, Park JM, Kang SJ, Lee JS, Kang E, Na DL, Kim SE (2005) 18F-FDG PET findings in frontotemporal dementia: an SPM analysis of 29 patients. J Nucl Med 46:233–239PubMed
Kertesz A, Davidson W, Fox H (1997) Frontal behavioral inventory: diagnostic criteria for frontal lobe dementia. Can J Neurol Sci 24:29–36CrossRef PubMed
Kipps CM, Davies RR, Mitchell J, Kril JJ, Halliday GM, Hodges JR (2007) Clinical significance of lobar atrophy in frontotemporal dementia: application of an MRI visual rating scale. Dement Geriatr Cogn Disord 23:334–342. doi:10.1159/000100973 CrossRef PubMed
Lerch J (2006) Voxel-wise morphometry using RMINC. http://www.bic.mni.mcgill.ca/~samir/Brain_imaging/RMINC.pdf . Accessed 15 July 2014
Llansola M, Felipo V (2010) Metabotropic glutamate receptor 5, but not 1, modulates NMDA receptor-mediated activation of neuronal nitric oxide synthase. Neurochem Int 56:535–545. doi:10.1016/j.neuint.2009.12.016 CrossRef PubMed
Mackenzie IR, Neumann M, Bigio EH, Cairns NJ, Alafuzoff I, Kril J, Kovacs GG, Ghetti B, Halliday G, Holm IE, Ince PG, Kamphorst W, Revesz T, Rozemuller AJ, Kumar-Singh S, Akiyama H, Baborie A, Spina S, Dickson DW, Trojanowski JQ, Mann DM (2010) Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol 119:1–4. doi:10.1007/s00401-009-0612-2 CrossRef PubMed PubMedCentral
Mackenzie IR, Munoz DG, Kusaka H, Yokota O, Ishihara K, Roeber S, Kretzschmar HA, Cairns NJ, Neumann M (2011) Distinct pathological subtypes of FTLD-FUS. Acta Neuropathol 121:207–218. doi:10.1007/s00401-010-0764-0 CrossRef PubMed
McCrimmon AW, Smith AD (2013) Test Review: review of the Wechsler Abbreviated Scale of Intelligence, Second Edition (WASI-II). J Psychoeduc Assess 31:337–341. doi:10.1177/0734282912467756 CrossRef
Mendez MF, Lauterbach EC, Sampson SM, ANPA Committee on Research (2008) An evidence-based review of the psychopathology of frontotemporal dementia: a report of the ANPA Committee on Research. J Neuropsychiatry Clin Neurosci 20:130–149. doi:10.1176/appi.neuropsych.20.2.130 CrossRef PubMed
Minuzzi L, Diksic M, Gauthier S, Quirion R, Rosa-Neto P (2009) In vitro quantification of mGluR5 in pons and cerebellum of human brain using [H-3]ABP688. J Cerebr Blood F Met 29:S368–S369
Muller-Gartner HW, Links JM, Prince JL, Bryan RN, McVeigh E, Leal JP, Davatzikos C, Frost JJ (1992) Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects. J Cereb Blood Flow Metab 12:571–583. doi:10.1038/jcbfm.1992.81 CrossRef PubMed
Narendran R, Hwang DR, Slifstein M, Talbot PS, Erritzoe D, Huang Y (2004) In vivo vulnerability to competition by dopamine: comparison of the D2 receptor agonist radiotracer (−)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-racloprid. Synapse 52:188–208. doi:10.1002/syn.20013 CrossRef PubMed
Natarajan MK, Paul N, Mercuri M, Waller EJ, Leipsic J, Traboulsi M, Banijamali HS, Benson L, Sheth TN, Secondary Panel: Simpson CS, Brydie A, Love MP, Gallo R, Canadian Cardiovascular Society (2013) Canadian Cardiovascular Society position statement on radiation exposure from cardiac imaging and interventional procedures. Can J Cardiol 29:1361–1368. doi:10.1016/j.cjca.2013.06.002 CrossRef PubMed
Nilsen LH, Rae C, Ittner LM, Gotz J, Sonnewald U (2013) Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation. J Cereb Blood Flow Metab 33:684–691. doi:10.1038/jcbfm.2012.212 CrossRef PubMed
Niswender CM, Conn PJ (2010) Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu Rev Pharmacol Toxicol 50:295–322. doi:10.1146/annurev.pharmtox.011008.145533 CrossRef PubMed PubMedCentral
Pan PL, Song W, Yang J, Huang R, Chen K, Gong QY, Zhong JG, Shi HC, Shang HF (2012) Gray matter atrophy in behavioral variant frontotemporal dementia: a meta-analysis of voxel-based morphometry studies. Dement Geriatr Cogn Disord 33:141–148. doi:10.1159/000338176 CrossRef PubMed
Perroy J, Raynaud F, Homburger V, Rousset MC, Telley L, Bockaert J, Fagni L (2008) Direct interaction enables cross-talk between ionotropic and group I metabotropic glutamate receptors. J Biol Chem 283:6799–6805. doi:10.1074/jbc.M705661200 CrossRef PubMed
Poljansky S, Ibach B, Hirschberger B, Manner P, Klunemann H, Hajak G, Marienhagen J (2011) A visual [18F]FDG-PET rating scale for the differential diagnosis of frontotemporal lobar degeneration. Eur Arch Psychiatry Clin Neurosci 261:433–446. doi:10.1007/s00406-010-0184-0 CrossRef PubMed
Procter AW, Qurne M, Francis PT (1999) Neurochemical features of frontotemporal dementia. Dement Geriatr Cogn Disord 10(Suppl 1):80–84. doi:10.1159/000051219 CrossRef PubMed
Quarantelli M, Berkouk K, Prinster A, Landeau B, Svarer C, Balkay L, Alfano B, Brunetti A, Baron JC, Salvatore M (2004) Integrated software for the analysis of brain PET/SPECT studies with partial-volume-effect correction. J Nucl Med 45:192–201PubMed
Rao VL, Bowen KK, Dempsey RJ (2001) Transient focal cerebral ischemia down-regulates glutamate transporters GLT-1 and EAAC1 expression in rat brain. Neurochem Res 26:497–502CrossRef PubMed
Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EG, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Grossman M, Miller BL (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 134:2456–2477. doi:10.1093/brain/awr179 CrossRef PubMed PubMedCentral
Ratnavalli E, Brayne C, Dawson K, Hodges JR (2002) The prevalence of frontotemporal dementia. Neurology 58:1615–1621CrossRef PubMed
Renton AE, Majounie E, Waite A, Simón-Sánchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, Scholz SW, Duckworth J, Ding J, Harmer DW, Hernandez DG, Johnson JO, Mok K, Ryten M, Trabzuni D, Guerreiro RJ, Orrell RW, Neal J, Murray A, Pearson J, Jansen IE, Sondervan D, Seelaar H, Blake D, Young K, Halliwell N, Callister JB, Toulson G, Richardson A, Gerhard A, Snowden J, Mann D, Neary D, Nalls MA, Peuralinna T, Jansson L, Isoviita VM, Kaivorinne AL, Hölttä-Vuori M, Ikonen E, Sulkava R, Benatar M, Wuu J, Chiò A, Restagno G, Borghero G, Sabatelli M, ITALSGEN Consortium, Heckerman D, Rogaeva E, Zinman L, Rothstein JD, Sendtner M, Drepper C, Eichler EE, Alkan C, Abdullaev Z, Pack SD, Dutra A, Pak E, Hardy J, Singleton A, Williams NM, Heutink P, Pickering-Brown S, Morris HR, Tienari PJ, Traynor BJ (2011) A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron 72:257–268. doi:10.1016/j.neuron.2011.09.010 CrossRef PubMed PubMedCentral
Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, Amaducci L, Orgogozo JM, Brun A, Hofman A, Moody DM, O’Brien MD, Yamaguchi T, Grafman J, Drayer BP, Bennett DA, Fisher M, Ogata J, Kokmen E, Bermejo F, Wolf PA, Gorelick PB, Bick KL, Pajeau AK, Bell MA, DeCarli C, Culebras A, Korczyn AD, Bogousslavsky J, Hartmann A, Scheinberg P (1993) Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 43:250–260CrossRef PubMed
Romano C, Yang WL, O’Malley KL (1996) Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J Biol Chem 271:28612–28616CrossRef PubMed
Rothstein JD (1996) Excitotoxicity hypothesis. Neurology 47:S19–S26CrossRef PubMed
Rousset OG, Ma Y, Evans AC (1998) Correction for partial volume effects in PET: principle and validation. J Nucl Med 39:904–911PubMed
Rousset O, Rahmim A, Alavi A, Zaidi H (2007) Partial volume correction strategies in PET. PET Clin 2:235–249CrossRef
Rosso SM, Donker Kaat L, Baks T, Joosse M, de Koning I, Pijnenburg Y, de Jong D, Dooijes D, Kamphorst W, Ravid R, Niermeijer MF, Verheij F, Kremer HP, Scheltens P, van Duijn CM, Heutink P, van Swieten JC (2003) Frontotemporal dementia in The Netherlands: patient characteristics and prevalence estimates from a population-based study. Brain 126:2016–2022. doi:10.1093/brain/awg204 CrossRef PubMed
Schaeffer E, Duplantier A (2010) Glutamate and Neurodegenerative Disease. In: Dominguez C (ed) Neurodegenerative Diseases. Springer-Verlag, Berlin, Heidelberg, pp 91–147CrossRef
Seneca N, Finnema SJ, Farde L, Gulyas B, Wikstrom HV, Halldin C, Innis RB (2006) Effect of amphetamine on dopamine D2 receptor binding in nonhuman primate brain: a comparison of the agonist radioligand [11C]MNPA and antagonist [11C]raclopride. Synapse 59:260–269. doi:10.1002/syn.20238 CrossRef PubMed
Sled JGZA, Evans AC (1998) A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging 17:87–97CrossRef PubMed
Swartz JR, Miller BL, Lesser IM, Booth R, Darby A, Wohl M, Benson DF (1997) Behavioral phenomenology in Alzheimer’s disease, frontotemporal dementia, and late-life depression: a retrospective analysis. J Geriatr Psychiatry Neurol 10:67–74CrossRef PubMed
Swarup V, Phaneuf D, Dupre N, Petri S, Strong M, Kriz J, Julien JP (2011) Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor kappaB-mediated pathogenic pathways. J Exp Med 208:2429–2447. doi:10.1084/jem.20111313 CrossRef PubMed PubMedCentral
Wilson AΑ, McCormick P, Kapur S, Willeit M, Garcia A, Hussey D, Houle S, Seeman P, Ginovart N (2005) Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography. J Med Chem 48:4153–4160. doi:10.1021/jm050155n CrossRef PubMed
Worsley KJ, Cao J, Paus T, Petrides M, Evans AC (1998) Applications of random field theory to functional connectivity. Hum Brain Mapp 6:364–367CrossRef PubMed
Zijdenbos AFR, Evans AC (1998) Automatic quantification of MS lesions in 3D MRI brain data sets: validation of INSECT. In: Wells M, Colchester A, Delp S (eds) Lecture Notes in Computer Science. Springer, Berlin, Heidelberg, New York, pp 438–448 - 作者单位：Antoine Leuzy (1) (2)
Eduardo Rigon Zimmer (1) (2) (3)
Jonathan Dubois (4)
Jens Pruessner (5) (6)
Cory Cooperman (6) (7)
Jean-Paul Soucy (8)
Alexey Kostikov (8)
Esther Schirmaccher (8)
René Désautels (9)
Serge Gauthier (2)
Pedro Rosa-Neto (1) (2)
1. Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging, McGill University, 6825 LaSalle Blvd, Montreal, QC, H4H 1R3, Canada
2. Alzheimer’s Disease Research Unit, McGill Centre for Studies in Aging, McGill University, Montreal, Canada
3. Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
4. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada
5. McGill Centre for Studies in Aging, McGill University, Montreal, Canada
6. Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, Canada
7. Department of Psychology, McGill University, Montreal, Canada
8. McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada
9. Division of Geriatric Psychiatry, Douglas Mental Health University Institute, Montreal, Canada - 刊物主题：Neurosciences; Cell Biology; Neurology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1863-2661
文摘
Although the pathogenesis underlying behavioral variant frontotemporal dementia (bvFTD) has yet to be fully understood, glutamatergic abnormalities have been hypothesized to play an important role. The aim of the present study was to determine the availability of the metabotropic glutamate receptor type 5 (mGluR5) using a novel positron emission tomography (PET) radiopharmaceutical with high selectivity for mGluR5 ([11C]ABP688) in a sample of bvFTD patients. In addition, we sought to determine the overlap between availability of mGluR5 and neurodegeneration, as measured using [18F]FDG-PET and voxel-based morphometry (VBM). Availability of mGluR5 and glucose metabolism ([18F]FDG) were measured in bvFTD (n = 5) and cognitively normal (CN) subjects (n = 10). [11C]ABP688 binding potential maps (BPND) were calculated using the cerebellum as a reference region, with [18F]FDG standardized uptake ratio maps (SUVR) normalized to the pons. Grey matter (GM) concentrations were determined using VBM. Voxel-based group differences were obtained using RMINC. BvFTD patients showed widespread decrements in [11C]ABP688 BPND throughout frontal, temporal and subcortical areas. These areas were likewise characterized by significant hypometabolism and GM loss, with overlap between reduced [11C]ABP688 BPND and hypometabolism superior to that for GM atrophy. Several regions were characterized only by decreased binding of [11C]ABP688. The present findings represent the first in vivo report of decreased availability of mGluR5 in bvFTD. This study suggests that glutamate excitotoxicity may play a role in the pathogenesis of bvFTD and that [11C]ABP688 may prove a suitable marker of glutamatergic neurotransmission in vivo.