Cystatin C uptake in the eye

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• 作者：Johan Wass¨¦lius ; Kjell Johansson ; Katarina H?kansson ; Magnus Abrahamson and Berndt Ehinger
• 刊名：Graefe's Archive for Clinical and Experimental Ophthalmology
• 出版年：2005
• 出版时间：June 2005
• 年：2005
• 卷：243
• 期：6
• 页码：583-592
• 全文大小：446 KB

文摘

Background As a secreted protein, cystatin C is assumed to play its role in the extracellular compartment, where it can inhibit virtually all cysteine proteases of families C1 (cathepsin B, L, S) and C13 (mammalian legumain-related proteases). Since many of its potential target enzymes in the eye reside in intracellular compartments, we sought evidence for a cellular uptake of the inhibitor in ocular tissues.