The Effect of Exposure to Cd and Pb in the Form of a Drinking Water or Feed on the Accumulation and Distribution of These Metals in the Organs of Growing Wistar Rats

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• 作者：Anna Winiarska-Mieczan ; Małgorzata Kwiecień
• 关键词：Cadmium ; Lead ; Organs accumulation ; Drinking water or feed exposure ; Growing rats
• 刊名：Biological Trace Element Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：169
• 期：2
• 页码：230-236
• 全文大小：273 KB
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• 作者单位：Anna Winiarska-Mieczan (1)
  Małgorzata Kwiecień (2)
  
  1. Department of Bromatology and Food Physiology, University of Life Sciences in Lublin, Akademicka 13, 20-950, Lublin, Poland
  2. Department of Animal Nutrition, University of Life Sciences in Lublin, Akademicka 13, 20-950, Lublin, Poland
  
• 刊物主题：Biochemistry, general; Biotechnology; Nutrition; Oncology;
• 出版者：Springer US
• ISSN：1559-0720

文摘

The degree of accumulation and distribution of Cd and Pb in the organs of young animals compared to the amount taken in with water or feed have not been thoroughly investigated yet. The experiment aimed to verify whether the source of toxic metals (feed, drinking water) administered to growing rats orally has an influence on the degree of accumulation of Cd and Pb in the organs (brain, spleen, lungs, heart, liver and kidneys). The rats received Cd and/or Pb respectively in the amount of 7 mg and/or 50 mg per 1 kg of feed or per 1 L of distilled water. The rats’ organs accumulated in total about 0.5 % Cd and about 0.71 % Pb consumed with water and about 0.46 % Cd and about 0.63 % Pb taken in with feed. More than 60 % of Cd and more than 70 % of Pb absorbed by the studied organs was accumulated in the liver, and more than 30 % of Cd and 26–29 % of Pb in the kidneys and less than 1 % in other organs. The relationship between the distribution percentage of Cd in the studied organs can be presented as: liver > kidneys > brain > lungs > heart > spleen. The relationship between the distribution percentage of Pb can be presented as: liver > kidneys > brain > spleen > heart > lungs. Significantly (P < 0.05), more Cd and Pb were accumulated in total in the organs of rats receiving the metals in drinking water. Keywords Cadmium Lead Organs accumulation Drinking water or feed exposure Growing rats