Efficacy of the Acorn Cardiac Support Device in Animals with Heart Failure Secondary to High Rate Pacing
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- 作者：John M. Power ; Jai Raman ; Melissa J. Byrne and Clif A Alferness
- 关键词：heart failure ; ovine model ; cardiac support device ; passive ventricular constraint
- 刊名：Heart Failure Reviews
- 出版年：2005
- 出版时间：June 2005
- 年：2005
- 卷：10
- 期：2
- 页码：117-123
- 全文大小：1,783 KB
文摘
Aim: To utilise an ovine model of tachycardia induced progressive dilated cardiomyopathy and heart failure to investigate the efficacy of passive ventricular constraint with the Acorn cardiac support device as a heart failure treatment. Methods: (a) Moderate heart failure was produced in 16 sheep by pacing for 3 weeks. Half were implanted and half sham implanted with the CSD. Pacing continued at a higher rate for an additional 3 weeks. Cardiac function was assessed by echocardiography and manometry. (b) Moderate heart failure was produced (as above) in 27 sheep, 9 were implanted with CSD, pacing was restarted for 4 weeks, the initial CSD implants were terminated and another 9 animals were CSD implanted (severe heart failure), pacing was restarted in the remaining 18 animals for an additional 4 weeks (total 12 weeks) and then all animals were terminated. Cardiac function was assessed using echocardiography and treadmill exercise testing.