Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARγ

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• 作者：J. S. Ruffino ; N. A. Davies ; K. Morris…
• 刊名：European Journal of Applied Physiology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：116
• 期：9
• 页码：1671-1682
• 全文大小：562 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Physiology
  Occupational and Industrial Medicine
  Sports Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1439-6327
• 卷排序：116

文摘

PurposeMonocytes may be primed towards differentiation into classically activated M1 macrophages or alternatively activated M2 macrophages. M1 macrophages greatly contribute to the inflammation which promotes insulin resistance, whereas M2 macrophages resolve inflammation. We have previously shown that exercise increases M2 marker expression in mixed mononuclear cells, possibly via activation of the nuclear transcription factor PPARγ. However, these effects have not been demonstrated specifically within monocytes. Thus, we aimed to investigate whether moderate-intensity exercise elicited similar effects on monocytic M1/M2 marker expression and PPARγ activity to those reported previously in mononuclear cells, so as to further elucidate the mechanisms by which exercise may alter inflammatory status and, accordingly, prevent insulin resistance.