Comparison of the efficiency of different NF membranes for the enrichment of milk oligosaccharides from bovine milk

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• 作者：Karina Altmann ; Adam Wutkowski ; Sebastian K?mpfer…
• 关键词：Enrichment of bovine milk oligosaccharides (MOS) by nanofiltration (NF) ; Retention of MOS ; Content of MOS in relation to total sugar content ; Transfer of NF process from laboratory to industrial scale ; NFκB activity ; Immunostimulatory effect
• 刊名：European Food Research and Technology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：241
• 期：6
• 页码：803-815
• 全文大小：741 KB
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• 作者单位：Karina Altmann (1)
  Adam Wutkowski (1)
  Sebastian K?mpfer (2)
  Martin Klempt (1)
  Peter Chr. Lorenzen (1)
  Ingrid Clawin-R?decker (1)
  
  1. Department of Safety and Quality of Milk and Fish Products, Max Rubner-Institut Kiel, Hermann-Weigmann-Stra?e 1, 24103, Kiel, Germany
  2. Central Production and Engineering, Müller Service GmbH, An den Breiten, 01454, Leppersdorf, Germany
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Food Science
  Analytical Chemistry
  Biotechnology
  Agriculture
  Forestry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1438-2385

文摘

Oligosaccharides in milk (MOS) have been reported in the literature to exert various bioactivities and to modulate the immune system. However, processes to obtain milk oligosaccharides on industrial scale as food ingredients are currently not available. Therefore, the aim of the study on hand was the evaluation of different nanofiltration (NF) membranes for the enrichment of MOS from bovine milk. Moreover, a transfer of the NF process from laboratory to pilot plant and industrial scale was performed. The immunostimulatory effect of the MOS concentrates was studied by the activity of NFκB in human embryotic kidney cells (HEKnfκbRE-cells). NF was carried out with lactose hydrolyzed skimmed and ultrafiltered milk permeate by application of different membranes. The quantification of MOS was determined by high-pH anion-exchange chromatography with pulsed amperometric detection and parallel online electrospray ion trap mass spectrometry. The enrichment of MOS (3-sialyl-lactose, 6-sialyl-lactose, N-acetylgalactosaminyl-lactose) on laboratory, pilot plant and industrial scale was achieved by the retention of these oligosaccharides of at least 50 % in NF retentate. The content of MOS in relation to total sugar content in the retentate from NF on industrial scale was 100-fold higher than in the initial sample. The MOS retentates and the standards (3-sialyl-lactose, 6-sialyl-lactose) exhibited increased NFκB activity in HEKnfκbRE-cells. Although there exist a few studies about the enrichment of MOS by NF, this is the first report about a screening of the efficiency of different NF membranes for the enrichment of MOS on different technological scales of production. Keywords Enrichment of bovine milk oligosaccharides (MOS) by nanofiltration (NF) Retention of MOS Content of MOS in relation to total sugar content Transfer of NF process from laboratory to industrial scale NFκB activity Immunostimulatory effect