Selenium Supplementation of Amaranth Sprouts Influences Betacyanin Content and Improves Anti-Inflammatory Properties via NFκB in Murine RAW 264.7 Macrophages

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• 作者：Malgorzata Tyszka-Czochara ; Pawel Pasko…
• 关键词：Selenium ; enriched amaranth sprouts ; Betacyanin ; Murine macrophage cell line (RAW 264.7) ; NFκB translocation ; Interleukin 6
• 刊名：Biological Trace Element Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：169
• 期：2
• 页码：320-330
• 全文大小：473 KB
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• 作者单位：Malgorzata Tyszka-Czochara (1)
  Pawel Pasko (2) (3)
  Pawel Zagrodzki (2) (4)
  Ewelina Gajdzik (2)
  Renata Wietecha-Posluszny (5)
  Shela Gorinstein (6)
  
  1. Department of Radioligands, Medical College, Jagiellonian University, Krakow, Poland
  2. Department of Food Chemistry and Nutrition, Medical College, Jagiellonian University, Medyczna 9, 30-688, Krakow, Poland
  3. Faculty of Health and Medical Science, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland
  4. Department of Nuclear Physical Chemistry, Institute of Nuclear Physics, Krakow, Poland
  5. Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Krakow, Poland
  6. The Institute for Drug Research, School of Pharmacy, The Hebrew University, Hadassah Medical School, Jerusalem, Israel
  
• 刊物主题：Biochemistry, general; Biotechnology; Nutrition; Oncology;
• 出版者：Springer US
• ISSN：1559-0720

文摘

Sprouts contain potent compounds which while influencing crucial transduction pathways in cell reveal anti-inflammatory and anticancer activities. In this study, we report the biological activity for seeds and colourful sprouts of four types of edible amaranth, as amaranth has recently attracted interest due to its appreciable nutritional value. MTT assay conducted for the amaranth seeds and sprouts did not show any adverse effect on the viability of murine RAW 264.7 cells. As amaranth accumulates selenium, the sprouts were supplemented with this trace element (10 mg/L; 15 mg/L Se as sodium selenite) while growing. Selenium concentration in sprouts was observed to be significantly correlated with betacyanins content of the tested species. The amounts of Se and betacyanins in sprouts varied for various Amaranth species. In the present study, Amaranthus cruentus sprouts with the highest betacyanins (19.30 ± 0.57–28.85 ± 2.23 mg of amaranthin/100 g of fresh weight) and high total selenium (22.51 ± 1.57–1044.75 ± 73.08 μg/L in methanol extracts) content prevented NFκB translocation to the cell nucleus and subsequently exerted an anti-inflammatory effect by significant decreasing inflammatory interleukin 6 production (587.3 ± 34.2–710.0 ± 88.1 pg/mL) in the cell culture of activated RAW 264.7 macrophages (vs LPS control 1520 ± 114 pg/mL). Keywords Selenium-enriched amaranth sprouts Betacyanin Murine macrophage cell line (RAW 264.7) NFκB translocation Interleukin 6