Correlation of EGFR mutation and predominant histologic subtype according to the new lung adenocarcinoma classification in Chinese patients

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• 作者：Zhengbo Song (1) (2)
  Huineng Zhu (2) (3)
  Zhenying Guo (2) (3)
  Wei Wu (2) (3)
  Wenyong Sun (2) (3)
  Yiping Zhang (1) (2)
  
• 关键词：Non ; small cell lung cancer ; Adenocarcinoma subtype ; EGFR mutation
• 刊名：Medical Oncology
• 出版年：2013
• 出版时间：September 2013
• 年：2013
• 卷：30
• 期：3
• 全文大小：163KB
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• 作者单位：Zhengbo Song (1) (2)
  Huineng Zhu (2) (3)
  Zhenying Guo (2) (3)
  Wei Wu (2) (3)
  Wenyong Sun (2) (3)
  Yiping Zhang (1) (2)
  
  1. Department of Chemotherapy, Zhejiang Cancer Hospital, 38 Guangji Road, Gongshu District, Hangzhou, 310022, People’s Republic of China
  2. Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Hangzhou, 310022, Zhejiang Province, China
  3. Department of Pathology, Zhejiang Cancer Hospital, Hangzhou, 310022, China
  

文摘

A new lung adenocarcinoma classification proposed by the International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society (IASLC/ATS/ERS) has recently been published. However, the relationship between EGFR mutations and subtype of adenocarcinoma remains unclear. A total of 161 surgically resected lung adenocarcinomas in Zhejiang Cancer Hospital were reviewed using the new classification system. Epidermal growth factor receptor (EGFR) mutations were observed in 67 cases (41.6?%). EGFR mutations were found to be closely associated with the micropapillary predominant subtype (P?=?0.0068) and lepidic component (P?=?0.005). The frequency of EGFR mutation was found to be lower in the solid predominant subtype than other subtype (P?=?0.04). In conclusion, histologic subtyping was found to be associated with EGFR mutations. The EGFR mutation frequency of micropapillary and lepidic predominant subtypes was found to be more pronounced than that of other subtypes.