Effects of NAD at purine receptors in isolated blood vessels
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- 作者：E. Alefishat ; S. P. H. Alexander ; V. Ralevic
- 关键词：NAD ; P2 purine receptors ; Adenosine receptors ; Artery ; Vasorelaxation
- 刊名：Purinergic Signalling
- 出版年：2015
- 出版时间：March 2015
- 年：2015
- 卷：11
- 期：1
- 页码：47-57
- 全文大小：1,872 KB
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S. P. H. Alexander (2)
V. Ralevic (2)
1. Department of Biopharmaceutics and Clinical Pharmacy Faculty of Pharmacy, University of Jordan, Amman, 11942, Jordan
2. School of Life Sciences Queen’s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Biomedicine
Pharmacology and Toxicology
Human Physiology
Neurosciences
Cancer Research - 出版者：Springer Netherlands
- ISSN：1573-9546
文摘
Nicotinamide adenine dinucleotide (NAD) belongs to the family of naturally occurring adenine dinucleotides, best known for their various intracellular roles. However, there is evidence that they can also be released from cells to act as novel extracellular signalling molecules. Relatively little is known about the extracellular actions of NAD, especially in the cardiovascular system. The present study investigated the actions of NAD in the rat thoracic aorta, porcine coronary artery and porcine mesenteric arteries, mounted in organ baths for isometric tension recording. In the rat thoracic aorta and porcine coronary artery, NAD caused endothelium-independent concentration-dependent vasorelaxations which were unaffected by palmitoylCoA, a P2Y1 receptor antagonist, but which were blocked by CGS15943, a non-selective adenosine receptor antagonist. In the porcine coronary artery, NAD-evoked relaxations were abolished by SCH58261, a selective A2A receptor antagonist. In the rat thoracic aorta, NAD-evoked relaxations were attenuated by A2A receptor antagonism with SCH58261 but were unaffected by an A2B receptor antagonist, MRS1754. In contrast, in the porcine mesenteric artery, NAD-evoked endothelium-independent contractions, which were unaffected by a P2 receptor antagonist, suramin, or by NF449, a P2X1 receptor antagonist, but were attenuated following P2X receptor desensitisation with αβ-meATP. In conclusion, the present results show that NAD can alter vascular tone through actions at purine receptors in three different arteries from two species; its molecular targets differ according to the type of blood vessel.