Salt-inducible kinase 2 and -3 are downregulated in adipose tissue from obese or insulin-resistant individuals: implications for insulin signalling and glucose uptake in human adipocytes
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- 作者：Johanna Säll ; Annie M. L. Pettersson ; Christel Björk ; Emma Henriksson…
- 关键词：Gene and protein expression ; Glucose uptake ; HOMA ; IR ; Inflammation ; Obesity ; Salt ; inducible kinase ; SIK2 ; SIK3 ; Weight loss
- 刊名：Diabetologia
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：60
- 期：2
- 页码：314-323
- 全文大小：631KB
- 刊物类别：Medicine
- 刊物主题：Internal Medicine; Metabolic Diseases; Human Physiology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-0428
- 卷排序：60
文摘
Aims/hypothesisSalt-inducible kinases (SIKs) are related to the metabolic regulator AMP-activated protein kinase (AMPK). SIK2 is abundant in adipose tissue. The aims of this study were to investigate the expression of SIKs in relation to human obesity and insulin resistance, and to evaluate whether changes in the expression of SIKs might play a causal role in the development of disturbed glucose uptake in human adipocytes.