Optical coherence tomography shows early loss of the inferior temporal quadrant retinal nerve fiber layer in autosomal dominant optic atrophy

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• 作者：Sung Wook Park ; Jeong-Min Hwang
• 关键词：Autosomal dominant optic atrophy ; Optical coherent tomography ; Papillomacular bundle ; Retinal nerve fiber layer ; Visual field
• 刊名：Graefe's Archive for Clinical and Experimental Ophthalmology
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：253
• 期：1
• 页码：135-141
• 全文大小：154 KB
• 参考文献：1. Kjer P (1959) Infantile optic atrophy with dominant mode of inheritance: a clinical and genetic study of 19 Danish families. Acta Ophthalmol (Copenh) 164:1-47
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Ophthalmology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-702X

文摘

Purpose The aim of the study was to evaluate the relationship between visual function and retinal nerve fiber layer thickness (RNFLT) determined using Stratus optical coherence tomography (OCT) in patients with autosomal dominant optic atrophy (ADOA). Methods The study was a retrospective, institutional, and comparative case series. Thirty-six consecutive patients with ADOA and 72 age-matched normal controls were compared with regard to RNFLT, best-corrected visual acuity (BCVA), and visual field. Results The relative reduction of RNFLT of ADOA patients was most evident in the temporal quadrant (56.8?%), followed by the inferior (35.5?%), superior (27.2?%), and nasal quadrants (26.4?%). In ADOA patients, BCVA decreased with RNFL thinning (p--.001), and was not related to age (p--.210). Papillomacular bundle RNFLT decreased with age throughout the study period of 3.7?±-.3?years (?.83?±-.96?μm, p--.017). The presence of a superotemporal central scotoma (61.1?%) was related to decreased inferotemporal RNFLT (7 and 8 o’clock, p--.016 and p--.036, respectively). Conclusions The papillomacular bundle RNFL of ADOA is most vulnerable and progressively damaged with age, despite early temporal RNFL loss. Early loss of inferior temporal RNFL in ADOA is related to superotemporal central scotoma.