Functional characterization of the active Mutator-like transposable element, Muta1 from the mosquito Aedes aegypti

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• 作者：Kun Liu ; Susan R. Wessler
• 关键词：Transposable elements ; Mutator ; like elements (MULE) ; Aedes aegypti ; Yeast assay ; Target site duplication (TSD) ; Transposase
• 刊名：Mobile DNA
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：8
• 期：1
• 全文大小：1354KB
• 刊物主题：Human Genetics; Animal Genetics and Genomics; Plant Genetics & Genomics; Developmental Biology; Microbiology; Microbial Genetics and Genomics;
• 出版者：BioMed Central
• ISSN：1759-8753
• 卷排序：8

文摘

BackgroundMutator-like transposable elements (MULEs) are widespread with members in fungi, plants, and animals. Most of the research on the MULE superfamily has focused on plant MULEs where they were discovered and where some are extremely active and have significant impact on genome structure. The maize MuDR element has been widely used as a tool for both forward and reverse genetic studies because of its high transposition rate and preference for targeting genic regions. However, despite being widespread, only a few active MULEs have been identified, and only one, the rice Os3378, has demonstrated activity in a non-host organism.