A new method of building permanent A-V block model: ablating his-bundle potential through femoral artery with pre-implanted biventricular pacemaker
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  • 作者:Zheng Cheng (9)
    Ye Hai-ge (10)
    Li Jin (9)
    Ye Wan-chun (11)
    Wang Lu-ping (9)
    Li Yue-chun (9)
    Lin Jia-Feng (9)

    9. Department of Cardiology
    ; Second Affiliated Hospital of Wenzhou Medical University ; 109 Xueyuan Road ; Wenzhou ; Zhejiang ; China
    10. Department of Hematology
    ; First Affiliated Hospital of Wenzhou Medical University ; Wenzhou ; 325000 ; China
    11. Department of TCM
    ; First Affiliated Hospital of Wenzhou Medical University ; Wenzhou ; 325000 ; China
  • 关键词:A ; V block ; His ; bundle potential ; Biventricular pacemaker ; Radiofrequency ablation ; Beagle ; Disease models
  • 刊名:BMC Cardiovascular Disorders
  • 出版年:2014
  • 出版时间:December 2014
  • 年:2014
  • 卷:14
  • 期:1
  • 全文大小:1,291 KB
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    23. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2261/14/164/prepub
  • 刊物主题:Cardiology; Cardiac Surgery; Angiology; Blood Transfusion Medicine; Internal Medicine;
  • 出版者:BioMed Central
  • ISSN:1471-2261
文摘
Background To explore the feasibility of a new method of achieving a permanent A-V block animal model. Methods 16 beagles were randomly divided into two groups based on the method of their pre-implanted biventricular pacemakers. (1) In the first group (8 beagles), the A-V block model was achieved by ablating his-bundle potential at the site of the left ventricular superior-septum, under the aortic sinus, through femoral artery. (2) In the second group (8 beagles), the A-V block model was achieved by ablating his-bundle potential at the triangle of Koch, through femoral vein. A complete A-V block model was achieved as a standard in this study. The success rates, intraoperative arrhythmias, operative and X-ray exposure time, intraoperative bleeding amount were assessed in this two groups, both animal models were followed up for four weeks and then fasted to monitor myocardial pathological changes. Results The success rate of the first group, which with fewer intraoperative arrhythmias, and less operative and X-ray exposure time, was significantly higher than the second group. Conclusions Compared with traditional animal method, our new method of ablating his-bundle potential at the left ventricle from the femoral artery has a higher success rate, fewer occurrence of malignant arrhythmias, and less operation and X-ray time. Thus, our new method should be preferred in the building of Permanent A-V Block Model.

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