Genomic Structure of the Immigrant Siddis of East Africa to Southern India: A Study of 20 Autosomal DNA Markers

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• 作者：Mansi Gauniyal (1)
  Aastha Aggarwal (1)
  Gautam K. Kshatriya (1) g26_51@yahoo.co.in
• 关键词：Siddis – ; Africans – ; Genetic distance – ; Average heterozygosity – ; Genetic – ; Admixture – ; Nonrandom association
• 刊名：Biochemical Genetics
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：49
• 期：7-8
• 页码：427-442
• 全文大小：247.6 KB
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• 作者单位：1. Department of Anthropology, University of Delhi, Delhi, 110007 India
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Biochemistry
  Zoology
  Medical Microbiology
  
• 出版者：Springer Netherlands
• ISSN：1573-4927

文摘

The Siddis are a tribal group of African origin living in Karnataka, India. They have undergone considerable cultural change due to their proximity to neighboring population groups. To understand the biological consequences of these changes, we describe the genomic structure of the Siddis and the contribution from putative ancestral populations using 20 autosomal DNA markers. The distribution of Alu indel markers and a genetic distance analysis reveals their closer affinities with Africans. The levels of genomic diversity and heterozygosity are high in all the populations of southern India. Genetic admixture analysis reveals a predominant contribution from Africans, a lesser contribution from south Indians, and a slight one from Europeans. There is no evidence of gametic disequilibrium in the Siddis. The genetic homogeneity of the Siddis, in spite of its admixed origin, suggests the utility of this population for genetic epidemiological studies.