Two common nonsynonymous paraoxonase 1 (PON1) gene polymorphisms and brain astrocytoma and meningioma

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• 作者：Carmen Martínez (1)
  José A Molina (2)
  Hortensia Alonso-Navarro (3) (4)
  Félix J Jiménez-Jiménez (3)
  José AG Agúndez (1)
  Elena García-Martín (5)
  
• 刊名：BMC Neurology
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：10
• 期：1
• 全文大小：253KB
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  66. The pre-publication history for this paper can be accessed here:medcentral.com/1471-2377/10/71/prepub" class="a-plus-plus">http://www.biomedcentral.com/1471-2377/10/71/prepub
  
• 作者单位：Carmen Martínez (1)
  José A Molina (2)
  Hortensia Alonso-Navarro (3) (4)
  Félix J Jiménez-Jiménez (3)
  José AG Agúndez (1)
  Elena García-Martín (5)
  
  1. Department of Pharmacology & Psychiatry, Medical School, University of Extremadura, Badajoz, Spain
  2. Service of Neurology, Hospital Doce de Octubre, Madrid, Spain
  3. Department of Medicine-Neurology, Hospital "Príncipe de Asturias", Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
  4. Section of Neurology, Hospital "La Mancha-Centro", Alcázar de San Juan, Ciudad Real, Spain
  5. Department of Biochemistry and Molecular Biology and Genetics, University of Extremadura, Avda de Elvas s/n, 06071, Badajoz, Spain
  

文摘

Background Human serum paraoxonase 1 (PON1) plays a major role in the metabolism of several organophosphorus compounds. The enzyme is encoded by the polymorphic gene PON1, located on chromosome 7q21.3. Aiming to identify genetic variations related to the risk of developing brain tumors, we investigated the putative association between common nonsynonymous PON1 polymorphisms and the risk of developing astrocytoma and meningioma. Methods Seventy one consecutive patients with brain tumors (43 with astrocytoma grade II/III and 28 with meningioma) with ages ranging 21 to 76 years, and 220 healthy controls subjects were analyzed for the frequency of the nonsynonymous PON1 genotypes L55M rs854560 and Q192R rs662. All participants were adult Caucasian individuals recruited in the central area of Spain. Results The frequencies of the PON1 genotypes and allelic variants of the polymorphisms PON1 L55M and PON1 Q192R did not differ significantly between patients with astrocytoma and meningioma and controls. The minor allele frequencies were as follows: PON1 55L, 0.398, 0.328 and 0.286 for patients with astrocytoma, meningioma and control individuals, respectively; PON1 192R, 0.341, 0.362 and 0.302 for patients with astrocytoma, meningioma and control individuals, respectively. Correction for age, gender, or education, made no difference in odds ratios and the p values remained non-significant. Haplotype association analyses did not identify any significant association with the risk of developing astrocytoma or meningioma. Conclusions Common nonsynonymous PON1 polymorphisms are not related with the risk of developing astrocytoma and meningioma.