NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis

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• 作者：José A G Agúndez ; Elena García-Martín ; Carmen Martínez ; Julián Benito-León…
• 关键词：Multiple sclerosis ; Genetics ; Genetic polymorphisms ; NQO1 ; Risk factors
• 刊名：BMC Neurology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：178 KB
• 参考文献：1. Giordano, M, D'Alfonso, S, Momigliano-Richiardi, P (2002) Genetics of multiple sclerosis: linkage and association studies. Am J Pharmacogenomics 2: pp. 37-58 CrossRef
  2. Dyment, DA, Ebers, GC, Sadovnick, AD (2004) Genetics of multiple sclerosis. Lancet Neurol 3: pp. 104-110 CrossRef
  3. Ramagopalan, SV, Deluca, GC, Degenhardt, A, Ebers, GC (2008) The genetics of clinical outcome in multiple sclerosis. J of Neuroimmunol 201-02: pp. 183-199 m.2008.02.016" target="_blank" title="It opens in new window">CrossRef
  4. Pugliatti, M, Harbo, HF, Holm?y, T, Kampman, MT, Myhr, KM, Riise, T, Wolfson, C (2008) Environmental risk factors in multiple sclerosis. Acta Neurol Scand Suppl 188: pp. 34-40 CrossRef
  5. Duque, B, Sepulcre, J, Bejarano, B, Samaranch, L, Pastor, P, Villoslada, P (2008) Memory decline evolves independently of disease activity in MS. Mult Scler 4: pp. 947-953 CrossRef
  6. Sawcer, S, Hellenthal, G, Pirinen, M, Spencer, CC, Patsopoulos, NA, Moutsianas, L, Dilthey, A, Su, Z, Freeman, C, Hunt, SE, Edkins, S, Gray, E, Booth, DR, Potter, SC, Goris, A, Band, G, Oturai, AB, Strange, A, Saarela, J, Bellenguez, C, Fontaine, B, Gillman, M, Hemmer, B, Gwilliam, R, Zipp, F, Jayakumar, A, Martin, R, Leslie, S, Hawkins, S, Giannoulatou, E (2011) Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476: pp. 214-219 CrossRef
  7. Patsopoulos, NA (2011) Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol 70: pp. 897-912 CrossRef
  8. Beecham, AH, Patsopoulos, NA, Xifara, DK, Davis, MF, Kemppinen, A, Cotsapas, C, Shah, TS, Spencer, C, Booth, D, Goris, A, Oturai, A, Saarela, J, Fontaine, B, Hemmer, B, Martin, C, Zipp, F, D'Alfonso, S, Martinelli-Boneschi, F, Taylor, B, Harbo, HF, Kockum, I, Hillert, J, Olsson, T, Ban, M, Oksenberg, JR, Hintzen, R, Barcellos, LF, Agliardi, C, Alfredsson, L, Alizadeh, M (2013) Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet 45: pp. 1353-1360 CrossRef
  9. Gourraud, PA, Harbo, HF, Hauser, SL, Baranzini, SE (2012) The genetics of multiple sclerosis: an up-to-date review. Immunol Rev 248: pp. 87-103 CrossRef
  10. LeVine, SM (1992) The role of reactive oxygen species in the pathogenesis of multiple sclerosis. Med Hypotheses 39: pp. 271-274 CrossRef
  11. Newcombe, J, Li, H, Cuzner, ML (1994) Low density lipoprotein uptake by macrophages in multiple sclerosis plaques: implications for pathogenesis. Neuropathol & Appl Neurobiol 20: pp. 152-162 CrossRef
  12. Haider, L, Fischer, MT, Frischer, JM, Bauer, J, H?ftberger, R, Botond, G, Esterbauer, H, Binder, CJ, Witztum, JL, Lassmann, H (2011) Oxidative damage in multiple sclerosis lesions. Brain 134: pp. 1914-1924 CrossRef
  13. van Horssen, J, Schreibelt, G, B?, L, Montagne, L, Drukarch, B, van Muiswinkel, FL, de Vries, HE (2006) NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions. Free Radic Biol Med 41: pp. 311-317 med.2006.04.013" target="_blank" title="It opens in new window">CrossRef
  14. van Horssen, J, Schreibelt, G, Drexhage, J, Hazes, T, Dijkstra, CD, van der Valk, P, de Vries, HE (2008) Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression. Free Radic Biol Med 45: pp. 1729-1737 med.2008.09.023" target="_blank" title="It opens in new window">CrossRef
• 刊物主题：Neurology; Neurochemistry; Neurosurgery;
• 出版者：BioMed Central
• ISSN：1471-2377

文摘

Background A possible role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis has been suggested. The detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1) has been found up-regulated in MS lesions. A previous report described an association between the SNP rs1800566 in the NQO1 gene and the risk for MS in the Greek population. The aim of this study was to replicate a possible influence of the. SNP rs1800566 in the NQO1 gene in the risk for MS in the Spanish Caucasian population. Methods We analyzed allelic and genotypic frequency of NQO1 rs1800566 in 290 patients with MS and 310 healthy controls, using TaqMan Assays. Results NQO1 rs1800566 allelic and genotypic frequencies did not differ significantly between MS patients and controls, and were unrelated with age of onset of MS, gender, and clinical type of MS. Conclusions Our results indicate that NQO1 rs1800566 does not have an effect on MS disease risk.