Endophthalmitis following intravitreal injection of anti-VEGF agents: long-term outcomes and the identification of unusual micro-organisms

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• 作者：Mira M. Sachdeva ; Ala Moshiri…
• 关键词：Endophthalmitis ; Intravitreal injection ; Vascular endothelial growth factor
• 刊名：Journal of Ophthalmic Inflammation and Infection
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：6
• 期：1
• 全文大小：594 KB
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• 作者单位：Mira M. Sachdeva (1)
  Ala Moshiri (2)
  Henry A. Leder (3)
  Adrienne W. Scott (1)
  
  1. The Wilmer Eye Institute, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD, USA
  2. UC Davis Eye Center, Sacramento, CA, USA
  3. Elman Retina Group, 9114 Philadelphia Road, Suite 310, Baltimore, MD, USA
  
• 刊物主题：Ophthalmology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1869-5760

文摘

Background While the development of targeted molecular therapy to inhibit vascular endothelial growth factor (VEGF) has revolutionized the treatment and visual prognosis of highly prevalent retinal diseases such as diabetic retinopathy and age-related macular degeneration, each intravitreal injection of these agents carries a small risk of endophthalmitis which can be visually devastating. In the absence of specific guidelines, current management of post-injection endophthalmitis is typically extrapolated from data regarding endophthalmitis occurring after cataract surgery despite potential differences in pathogenic organisms and clinical course. Here, we assess the contribution of intravitreal injections of anti-VEGF agents to all cases of endophthalmitis at our tertiary care referral center and characterize the clinical outcomes and microbial pathogens associated with post-injection endophthalmitis in order to inform management of this serious iatrogenic condition.