HIV-1–neutrophil interactions trigger neutrophil activation and Toll-like receptor expression

详细信息    查看全文

• 作者：Diana Marcela Giraldo ; Juan Carlos Hernandez ; Paula Velilla…
• 关键词：Neutrophils ; TLRs ; PAMPs ; HIV ; 1 ; Cytokines
• 刊名：Immunologic Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：64
• 期：1
• 页码：93-103
• 全文大小：757 KB
• 参考文献：1. UNAIDS. Global report: UNAIDS report on the global AIDS epidemic; 2012.
  2.Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol. 2011;30(1):16–34.CrossRef PubMed
  3.Takeuchi O, Akira S. Innate immunity to virus infection. Immunol Rev. 2009;227(1):75–86.CrossRef PubMed
  4.Vercammen E, Staal J, Beyaert R. Sensing of viral infection and activation of innate immunity by toll-like receptor 3. Clin Microbiol Rev. 2008;21(1):13–25.PubMedCentral CrossRef PubMed
  5.Vincent IE, Zannetti C, Lucifora J, Norder H, Protzer U, Hainaut P, et al. Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells. PLoS ONE. 2011;6(10):e26315.PubMedCentral CrossRef PubMed
  6.Hernández JC, Arteaga J, Paul S, Kumar A, Latz E, Urcuqui-Inchima S. Up-regulation of TLR2 and TLR4 in dendritic cells in response to HIV type 1 and coinfection with opportunistic pathogens. AIDS Res Hum Retroviruses. 2011;27(10):1099–109.PubMedCentral CrossRef PubMed
  7.Sundstrom JB, Little DM, Villinger F, Ellis JE, Ansari AA. Signaling through Toll-like receptors triggers HIV-1 replication in latently infected mast cells. J Immunol. 2004;172(7):4391–401.CrossRef PubMed
  8.Mantovani A, Cassatella MA, Costantini C, Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol. 2011;11(8):519–31.CrossRef PubMed
  9.Martínez J, Hernández J, Urcuqui-Inchima S. La estimulación de TLR, receptores tipo NOD y dectina-1 en neutrófilos humanos induce la producción de citocinas proinflamatorias IATREIA. 2014;27(2):135-46.
  10.Hayashi F, Means TK, Luster AD. Toll-like receptors stimulate human neutrophil function. Blood. 2003;102(7):2660–9.CrossRef PubMed
  11.Janke M, Poth J, Wimmenauer V, Giese T, Coch C, Barchet W, et al. Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8. J Allergy Clin Immunol. 2009;123(5):1026–33.CrossRef PubMed
  12.Sabroe I, Prince LR, Jones EC, Horsburgh MJ, Foster SJ, Vogel SN, et al. Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span. J Immunol. 2003;170(10):5268–75.CrossRef PubMed
  13.Sabroe I, Dower SK, Whyte MK. The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis. Clin Infect Dis. 2005;41(Suppl 7):S421–6.CrossRef PubMed
  14.Ogier-Denis E, Mkaddem SB, Vandewalle A. NOX enzymes and Toll-like receptor signaling. Semin Immunopathol. 2008;30(3):291–300.CrossRef PubMed
  15.Mastroianni CM, Lichtner M, Mengoni F, D’Agostino C, Forcina G, d’Ettorre G, et al. Improvement in neutrophil and monocyte function during highly active antiretroviral treatment of HIV-1-infected patients. AIDS. 1999;13(8):883–90.CrossRef PubMed
  16.Segal AW. How neutrophils kill microbes. Annu Rev Immunol. 2005;23:197–223.PubMedCentral CrossRef PubMed
  17.Hayes PJ, Miao YM, Gotch FM, Gazzard BG. Alterations in blood leucocyte adhesion molecule profiles in HIV-1 infection. Clin Exp Immunol. 1999;117(2):331–4.PubMedCentral CrossRef PubMed
  18.Moore DA, Henderson D, Gazzard BG. Neutrophil adhesion molecules in HIV disease. Clin Exp Immunol. 1998;114(1):73–7.PubMedCentral CrossRef PubMed
  19.Bowers NL, Helton ES, Huijbregts RP, Goepfert PA, Heath SL, Hel Z. Immune suppression by neutrophils in HIV-1 infection: role of PD-L1/PD-1 pathway. PLoS Pathog. 2014;10(3):e1003993.PubMedCentral CrossRef PubMed
  20.Jaovisidha P, Peeples ME, Brees AA, Carpenter LR, Moy JN. Respiratory syncytial virus stimulates neutrophil degranulation and chemokine release. J Immunol. 1999;163(5):2816–20.PubMed
  21.Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, et al. Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1. Cell Host Microbe. 2012;12(1):109–16.CrossRef PubMed
  22.Clark RA, Nauseef WM. Isolation and functional analysis of neutrophils. Curr Protoc Immunol. 2001. doi: 10.​1002/​0471142735 .
  23.Hernández JC, Stevenson M, Latz E, Urcuqui-Inchima S. HIV type 1 infection up-regulates TLR2 and TLR4 expression and function in vivo and in vitro. AIDS Res Hum Retrovir. 2012;28(10):1313–28.PubMedCentral CrossRef PubMed
  24.Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity. 2011;34(5):637–50.CrossRef PubMed
  25.Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol. 2005;6(8):769–76.PubMedCentral CrossRef PubMed
  26.Ghosh TK, Mickelson DJ, Solberg JC, Lipson KE, Inglefield JR, Alkan SS. TLR-TLR cross talk in human PBMC resulting in synergistic and antagonistic regulation of type-1 and 2 interferons, IL-12 and TNF-alpha. Int Immunopharmacol. 2007;7(8):1111–21.CrossRef PubMed
  27.Szabo A, Magyarics Z, Pazmandi K, Gopcsa L, Rajnavolgyi E, Bacsi A. TLR ligands upregulate RIG-I expression in human plasmacytoid dendritic cells in a type I IFN-independent manner. Immunol Cell Biol. 2014;92(8):671–8.CrossRef PubMed
  28.Bekeredjian-Ding I, Roth SI, Gilles S, Giese T, Ablasser A, Hornung V, et al. T cell-independent, TLR-induced IL-12p70 production in primary human monocytes. J Immunol. 2006;176(12):7438–46.CrossRef PubMed
  29.He S, Liang Y, Shao F, Wang X. Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc Natl Acad Sci U S A. 2011;108(50):20054–9.PubMedCentral CrossRef PubMed
  30.Mäkelä SM, Strengell M, Pietilä TE, Osterlund P, Julkunen I. Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells. J Leukoc Biol. 2009;85(4):664–72.CrossRef PubMed
  31.Hoshino S, Konishi M, Mori M, Shimura M, Nishitani C, Kuroki Y, et al. HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency. J Leukoc Biol. 2010;87(6):1133–43.CrossRef PubMed
  32.Lester RT, Yao XD, Ball TB, McKinnon LR, Omange WR, Kaul R, et al. HIV-1 RNA dysregulates the natural TLR response to subclinical endotoxemia in Kenyan female sex-workers. PLoS ONE. 2009;4(5):e5644.PubMedCentral CrossRef PubMed
  33.Sanders CM, Cruse JM, Lewis RE. Toll-like receptors, cytokines and HIV-1. Exp Mol Pathol. 2008;84(1):31–6.CrossRef PubMed
  34.Lester RT, Yao XD, Ball TB, McKinnon LR, Kaul R, Wachihi C, et al. Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection. AIDS. 2008;22(6):685–94.CrossRef PubMed
  35.Equils O, Faure E, Thomas L, Bulut Y, Trushin S, Arditi M. Bacterial lipopolysaccharide activates HIV long terminal repeat through Toll-like receptor 4. J Immunol. 2001;166(4):2342–7.CrossRef PubMed
  36.Steinman RM, Hemmi H. Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol. 2006;311:17–58.PubMed
  37.Lee RM, White MR, Hartshorn KL. Influenza a viruses upregulate neutrophil toll-like receptor 2 expression and function. Scand J Immunol. 2006;63(2):81–9.CrossRef PubMed
  38.Kedzierska K, Crowe SM. Cytokines and HIV-1: interactions and clinical implications. Antivir Chem Chemother. 2001;12(3):133–50.CrossRef PubMed
  39.Roberts L, Passmore JA, Williamson C, Little F, Bebell LM, Mlisana K, et al. Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression. AIDS. 2010;24(6):819–31.PubMedCentral CrossRef PubMed
  40.Kobayashi SD, Voyich JM, DeLeo FR. Regulation of the neutrophil-mediated inflammatory response to infection. Microbes Infect. 2003;5(14):1337–44.CrossRef PubMed
  41.Vlahos R, Stambas J, Selemidis S. Suppressing production of reactive oxygen species (ROS) for influenza a virus therapy. Trends Pharmacol Sci. 2012;33(1):3–8.CrossRef PubMed
  42.Snelgrove RJ, Edwards L, Rae AJ, Hussell T. An absence of reactive oxygen species improves the resolution of lung influenza infection. Eur J Immunol. 2006;36(6):1364–73.CrossRef PubMed
  43.Pal S, Polyak SJ, Bano N, Qiu WC, Carithers RL, Shuhart M, et al. Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1. J Gastroenterol Hepatol. 2010;25(3):627–34.PubMedCentral CrossRef PubMed
  44.Elbim C, Prevot MH, Bouscarat F, Franzini E, Chollet-Martin S, Hakim J, et al. Polymorphonuclear neutrophils from human immunodeficiency virus-infected patients show enhanced activation, diminished fMLP-induced L-selectin shedding, and an impaired oxidative burst after cytokine priming. Blood. 1994;84(8):2759–66.PubMed
  45.Emaleu SB, Atkuri K. Immunological and redox biomarkers of neutrophils function inHIV/AIDS disease. Retrovirology. 2009;6(Suppl 2):35.CrossRef
  46.Salmen S, Colmenares M, Peterson DL, Reyes E, Rosales JD, Berrueta L. HIV-1 Nef associates with p22-phox, a component of the NADPH oxidase protein complex. Cell Immunol. 2010;263(2):166–71.CrossRef PubMed
  47.Kavoosi G, Ardestani SK, Kariminia A. The involvement of TLR2 in cytokine and reactive oxygen species (ROS) production by PBMCs in response to Leishmania major phosphoglycans (PGs). Parasitology. 2009;136(10):1193–9.CrossRef PubMed
  48.Prince LR, Whyte MK, Sabroe I, Parker LC. The role of TLRs in neutrophil activation. Curr Opin Pharmacol. 2011;11(4):397–403.CrossRef PubMed
  49.József L, Khreiss T, El Kebir D, Filep JG. Activation of TLR-9 induces IL-8 secretion through peroxynitrite signaling in human neutrophils. J Immunol. 2006;176(2):1195–202.CrossRef PubMed
  50.Jenne CN, Kubes P. NETs tangle with HIV. Cell Host Microbe. 2012;12(1):5–7.CrossRef PubMed
  51.Hernandez JC, Giraldo DM, Paul S, Urcuqui-Inchima S. Involvement of neutrophil hyporesponse and the role of Toll-like receptors in human immunodeficiency virus 1 protection. PLoS ONE. 2015;10(3):e0119844.PubMedCentral CrossRef PubMed
  52.Pillay J, Kamp VM, van Hoffen E, Visser T, Tak T, Lammers JW, et al. A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1. J Clin Invest. 2012;122(1):327–36.PubMedCentral CrossRef PubMed
  53.Buitendijk M, Eszterhas SK, Howell AL. Toll-like receptor agonists are potent inhibitors of human immunodeficiency virus-type 1 replication in peripheral blood mononuclear cells. AIDS Res Hum Retroviruses. 2014;30(5):457–67.CrossRef PubMed
  54.Youssef PP, Mantzioris BX, Roberts-Thomson PJ, Ahern MJ, Smith MD. Effects of ex vivo manipulation on the expression of cell adhesion molecules on neutrophils. J Immunol Methods. 1995;186(2):217–24.CrossRef PubMed
  55.Meddows-Taylor S, Kuhn L, Meyers TM, Tiemessen CT. Altered expression of L-selectin (CD62L) on polymorphonuclear neutrophils of children vertically infected with human immunodeficiency virus type 1. J Clin Immunol. 2001;21(4):286–92.CrossRef PubMed
  56.Wang SZ, Smith PK, Lovejoy M, Bowden JJ, Alpers JH, Forsyth KD. Shedding of L-selectin and PECAM-1 and upregulation of Mac-1 and ICAM-1 on neutrophils in RSV bronchiolitis. Am J Physiol. 1998;275(5 Pt 1):L983–9.PubMed
  57.Elsenberg EH, Sels JE, Hillaert MA, Schoneveld AH, van den Dungen NA, van Holten TC, et al. Increased cytokine response after toll-like receptor stimulation in patients with stable coronary artery disease. Atherosclerosis. 2013;231(2):346–51.CrossRef PubMed
  58.Hajishengallis G, Lambris JD. Crosstalk pathways between Toll-like receptors and the complement system. Trends Immunol. 2010;31(4):154–63.PubMedCentral CrossRef PubMed
  59.Fan J. TLR cross-talk mechanism of hemorrhagic shock-primed pulmonary neutrophil infiltration. Open Crit Care Med J. 2010;2:1–8.PubMedCentral CrossRef PubMed
  60.Creagh EM, O’Neill LA. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol. 2006;27(8):352–7.CrossRef PubMed
  61.Bagchi A, Herrup EA, Warren HS, Trigilio J, Shin HS, Valentine C, et al. MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. J Immunol. 2007;178(2):1164–71.CrossRef PubMed
  
• 作者单位：Diana Marcela Giraldo (1)
  Juan Carlos Hernandez (2)
  Paula Velilla (1)
  Silvio Urcuqui-Inchima (1)
  
  1. Grupo Inmunovirología, Universidad de Antioquia, St 62 No. 52-59, Medellín, Colombia
  2. Infettare, Facultad de Medicina, Universidad Cooperativa de Colombia, Medellín, Colombia
  
• 刊物主题：Allergology; Immunology; Medicine/Public Health, general; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-0755

文摘

Although neutrophils are the first-line of host defense against infection and express a wide number of pattern recognition receptors (PRRs), the function of these PRRs, including Toll-like receptors (TLRs), in HIV-1 infection remains unclear. TLRs play an important role in innate immunity, and while their involvement in viral immune pathogenesis was recently proposed, little is known about their expression and function during the neutrophil response to HIV-1 exposure. Here, we have shown that freshly isolated human neutrophils from healthy donors exhibited altered TLR expression, which may affect their function, after being challenged with HIV-1, alone or in the presence of TLR agonists. TLRs may promote neutrophil activation, pro-inflammatory cytokine secretion, and the production of reactive oxygen species. To our knowledge, this study is the first demonstration of functional TLR expression on neutrophils in response to HIV-1 treatment, suggesting a possible neutrophil/HIV-1 interaction through TLRs. Although additional studies are required to confirm the function of TLRs in neutrophils, our data clearly suggest that they play a role in the regulation of innate immunity by neutrophils, which could be engaged in HIV-1 pathogenesis or host defense. Keywords Neutrophils TLRs PAMPs HIV-1 Cytokines