The molecular mechanism of azole resistance in Aspergillus fumigatus: from bedside to bench and back
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- 作者：Xiaolei Wei (1)
Yuanwei Zhang (1)
Ling Lu (1)
1. Jiangsu Key Laboratory for Microbes and Functional Genomics ; Jiangsu Engineering and Technology Research Center for Microbiology ; College of Life Sciences ; Nanjing Normal University ; Nanjing ; 210023 ; P. R. China - 关键词：azole resistance ; pathogenic fungi ; Aspergillus fumigatus ; antifungal susceptibility testing
- 刊名：Journal of Microbiology
- 出版年：2015
- 出版时间：February 2015
- 年：2015
- 卷：53
- 期：2
- 页码：91-99
- 全文大小：390 KB
- 参考文献：1. Arendrup, M.C., Cuenca-Estrella, M., Lass-Florl, C., Hope, W.W., and European Committee on Antimicrobial Susceptibility Testing Subcommittee on Antifungal Susceptibility, T. 2012. EUCAST technical note on Aspergillus and amphotericin B, itraconazole, and posaconazole. / Clin. Microbiol. Infect. 18, E248鈥?50. CrossRef
2. Bader, O., Weig, M., Reichard, U., Lugert, R., Kuhns, M., Christner, M., Held, J., Peter, S., Schumacher, U., Buchheidt, D., et al. 2013. cyp51A-Based mechanisms of / Aspergillus fumigatus azole drug resistance present in clinical samples from Germany. / Antimicrob. Agents Chemother. 57, 3513鈥?517. CrossRef
3. Becher, R. and Wirsel, S.G. 2012. Fungal cytochrome P450 sterol 14alpha-demethylase (Cyp51) and azole resistance in plant and human pathogens. / Appl. Microbiol. Biotechnol. 95, 825鈥?40. CrossRef
4. Blatzer, M., Barker, B.M., Willger, S.D., Beckmann, N., Blosser, S.J., Cornish, E.J., Mazurie, A., Grahl, N., Haas, H., and Cramer, R.A. 2011. SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen / Aspergillus fumigatus. / PLoS Genet. 7, e1002374. CrossRef
5. Blosser, S.J. and Cramer, R.A. 2011. SREBP-dependent triazole susceptibility in / Aspergillus fumigatus is mediated through direct transcriptional regulation of / erg11A ( / cyp51A). / Antimicrob. Agents Chemother. 56, 248鈥?57. CrossRef
6. Bueid, A., Howard, S.J., Moore, C.B., Richardson, M.D., Harrison, E., Bowyer, P., and Denning, D.W. 2010. Azole antifungal resistance in / Aspergillus fumigatus: 2008 and 2009. / J. Antimicrob. Chemother. 65, 2116鈥?118. CrossRef
7. Buied, A., Moore, C.B., Denning, D.W., and Bowyer, P. 2013. High-level expression of cyp51B in azole-resistant clinical / Aspergillus fumigatus isolates. / J. Antimicrob. Chemother. 68, 512鈥?14. CrossRef
8. Calo, S., Shertz-Wall, C., Lee, S.C., Bastidas, R.J., Nicolas, F.E., Granek, J.A., Mieczkowski, P., Torres-Martinez, S., Ruiz-Vazquez, R.M., Cardenas, M.E., et al. 2014. Antifungal drug resistance evoked via RNAi-dependent epimutations. / Nature 513, 555鈥?58. CrossRef
9. Camps, S.M., Dutilh, B.E., Arendrup, M.C., Rijs, A.J., Snelders, E., Huynen, M.A., Verweij, P.E., and Melchers, W.J. 2012. Discovery of a HapE mutation that causes azole resistance in / Aspergillus fumigatus through whole genome sequencing and sexual crossing. / PLoS One 7, e50034. CrossRef
10. Cannon, R.D., Lamping, E., Holmes, A.R., Niimi, K., Baret, P.V., Keniya, M.V., Tanabe, K., Niimi, M., Goffeau, A., and Monk, B.C. 2009. Efflux-mediated antifungal drug resistance. / Clin. Microbiol. Rev. 22, 291鈥?21, Table of Contents. CrossRef
11. Carvalho, P., Goder, V., and Rapoport, T.A. 2006. Distinct ubiquitin-ligase complexes define convergent pathways for the deg-radation of ER proteins. / Cell 126, 361鈥?73. CrossRef
12. Castro, C., Serrano, M.C., Flores, B., Espinel-Ingroff, A., and Martin-Mazuelos, E. 2004. Comparison of the sensititre yeastone colorimetric antifungal panel with a modified NCCLS M38-A method to determine the activity of voriconazole against clinical isolates of / Aspergillus spp. / J. Clin. Microbiol. 42, 4358鈥?360. CrossRef
13. Chen, W., Lee, M.K., Jefcoate, C., Kim, S.C., Chen, F., and Yu, J.H. 2014. Fungal cytochrome p450 monooxygenases: their distribution, structure, functions, family expansion, and evolutionary origin. / Genome Biol. Evol. 6, 1620鈥?634. CrossRef
14. Chowdhary, A., Kathuria, S., Xu, J., Sharma, C., Sundar, G., Singh, P.K., Gaur, S.N., Hagen, F., Klaassen, C.H., and Meis, J.F. 2012. Clonal expansion and emergence of environmental multiple-triazole-resistant / Aspergillus fumigatus strains carrying the TR(3)(4)/L98H mutations in the cyp51A gene in India. / PLoS One 7, e52871. CrossRef
15. Chowdhary, A., Sharma, C., Hagen, F., and Meis, J.F. 2014. Exploring azole antifungal drug resistance in / Aspergillus fumigatus with special reference to resistance mechanisms. / Future Microbiol. 9, 697鈥?11. CrossRef
16. Chryssanthou, E. and Cuenca-Estrella, M. 2006. Comparison of the EUCAST-AFST broth dilution method with the CLSI reference broth dilution method (M38-A) for susceptibility testing of posaconazole and voriconazole against / Aspergillus spp. / Clin. Microbiol. Infect. 12, 901鈥?04. CrossRef
17. Chung, H. and Sidhu, K.S. 2008. Epigenetic modifications of embryonic stem cells: current trends and relevance in developing regenerative medicine. / Stem Cells Cloning 1, 11鈥?1.
18. Coleman, J.J. and Mylonakis, E. 2009. Efflux in fungi: la piece de resistance. / PLoS Pathog. 5, e1000486. CrossRef
19. Costa, C., Dias, P.J., Sa-Correia, I., and Teixeira, M.C. 2014. MFS multidrug transporters in pathogenic fungi: do they have real clinical impact? / Front. Physiol. 5, 197.
20. Cowen, L.E. 2008. The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype. / Nature Rev. Microbiol. 6, 187鈥?98. CrossRef
21. Cowen, L.E. 2009. Hsp90 orchestrates stress response signaling governing fungal drug resistance. / PLoS Pathog. 5, e1000471. CrossRef
22. Cowen, L.E. 2013. The fungal Achilles鈥?heel: targeting Hsp90 to cripple fungal pathogens. / Curr. Opin. Microbiol. 16, 377鈥?84. CrossRef
23. Cowen, L.E., Sanglard, D., Howard, S.J., Rogers, P.D., and Perlin, D.S. 2014. Mechanisms of antifungal drug resistance. / Cold Spring Harb. Perspect. Med. Doi: 10.1101/cshperspect.a019752 .
24. Cuenca-Estrella, M. 2014. Antifungal drug resistance mechanisms in pathogenic fungi: from bench to bedside. / Clin. Microbiol. Infect. 20 Suppl 6, 54鈥?9. CrossRef
25. Denning, D.W. and Perlin, D.S. 2011. Azole resistance in Aspergillus: a growing public health menace. / Future Microbiol. 6, 1229鈥?232. CrossRef
26. Denning, D.W., Venkateswarlu, K., Oakley, K.L., Anderson, M.J., Manning, N.J., Stevens, D.A., Warnock, D.W., and Kelly, S.L. 1997. Itraconazole resistance in / Aspergillus fumigatus. / Antimicrob. Agents Chemother. 41, 1364鈥?368.
27. Diaz-Guerra, T.M., Mellado, E., Cuenca-Estrella, M., and Rodriguez-Tudela, J.L. 2003. A point mutation in the 14伪-sterol demethy-lase gene / cyp51A contributes to itraconazole resistance in / Aspergillus fumigatus. / Antimicrob. Agents Chemother. 47, 1120鈥?124. CrossRef
28. Dirr, F., Echtenacher, B., Heesemann, J., Hoffmann, P., Ebel, F., and Wagener, J. 2010. AfMkk2 is required for cell wall integrity signaling, adhesion, and full virulence of the human pathogen / Aspergillus fumigatus. / Int. J. Med. Microbiol. 300, 496鈥?02. CrossRef
29. Epp, E., Vanier, G., Harcus, D., Lee, A.Y., Jansen, G., Hallett, M., Sheppard, D.C., Thomas, D.Y., Munro, C.A., Mullick, A., and Whiteway, M. 2010. Reverse genetics in / Candida albicans predicts ARF cycling is essential for drug resistance and virulence. / PLoS Pathog. 6, e1000753. CrossRef
30. Espinel-Ingroff, A., Arthington-Skaggs, B., Iqbal, N., Ellis, D., Pfaller, M.A., Messer, S., Rinaldi, M., Fothergill, A., Gibbs, D.L., and Wang, A. 2007. Multicenter evaluation of a new disk agar diffusion method for susceptibility testing of filamentous fungi with voriconazole, posaconazole, itraconazole, amphotericin B, and caspofungin. / J. Clin. Microbiol. 45, 1811鈥?820. CrossRef
31. Espinel-Ingroff, A., Diekema, D.J., Fothergill, A., Johnson, E., Pelaez, T., Pfaller, M.A., Rinaldi, M.G., Canton, E., and Turnidge, J. 2010. Wild-type MIC distributions and epidemiological cutoff values for the triazoles and six / Aspergillus spp. for the CLSI broth microdilution method (M38-A2 document). / J. Clin. Microbiol. 48, 3251鈥?257. CrossRef
32. Espinel-Ingroff, A. and Rezusta, A. 2002. E-test method for testing susceptibilities of / Aspergillus spp. to the new triazoles voriconazole and posaconazole and to established antifungal agents: comparison with NCCLS broth microdilution method. / J. Clin. Microbiol. 40, 2101鈥?107. CrossRef
33. Ferreira, M.E., Colombo, A.L., Paulsen, I., Ren, Q., Wortman, J., Huang, J., Goldman, M.H., and Goldman, G.H. 2005. The ergosterol biosynthesis pathway, transporter genes, and azole resistance in / Aspergillus fumigatus. / Med. Mycol. 43 Suppl 1, S313鈥?19. CrossRef
34. Fothergill, A.W. 2012. Antifungal susceptibility testing: Clinical Laboratory and Standards Institute (CLSI) Methods. pp. 65鈥?4.
35. Fraczek, M.G., Bromley, M., and Bowyer, P. 2011. An improved model of the / Aspergillus fumigatus Cyp51A protein. / Antimicrob. Agents Chemother. 55, 2483鈥?486. CrossRef
36. Fraczek, M.G., Bromley, M., Buied, A., Moore, C.B., Rajendran, R., Rautemaa, R., Ramage, G., Denning, D.W., and Bowyer, P. 2013. The cdr1B efflux transporter is associated with non-cyp51A-mediated itraconazole resistance in / Aspergillus fumigatus. / J. Antimicrob. Chemother. 68, 1486鈥?496. CrossRef
37. Furustrand Tafin, U., Clauss, M., Hauser, P.M., Bille, J., Meis, J.F., and Trampuz, A. 2012. Isothermal microcalorimetry: a novel method for real-time determination of antifungal susceptibility of Aspergillus species. / Clin. Microbiol. Infect. 18, e241鈥?45. CrossRef
38. Galimberti, R., Torre, A.C., Baztan, M.C., and Rodriguez-Chiappetta, F. 2012. Emerging systemic fungal infections. / Clin. Dermatol. 30, 633鈥?50. CrossRef
39. Gu, L., Frommel, S.C., Oakes, C.C., Simon, R., Grupp, K., Gerig, C.Y., Bar, D., Robinson, M.D., Baer, C., Weiss, M., et al. 2014. BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence. / Nat. Genet. 47, 22鈥?0. CrossRef
40. Guinea, J., Pelaez, T., Alcala, L., and Bouza, E. 2006. Comparison of Sensititre YeastOne with the NCCLS M38-A microdilution method to determine the activity of amphotericin B, voriconazole, and itraconazole against clinical isolates of / Aspergillus fumigatus. / Diagn. Microbiol. Infect. Dis. 56, 53鈥?5. CrossRef
41. Horn, S.C., Hanna, J., Hirsch, C., Volkwein, C., Schutz, A., Heinemann, U., Sommer, T., and Jarosch, E. 2009. Usa1 functions as a scaffold of the HRD-ubiquitin ligase. / Mol. Cell 36, 782鈥?93. CrossRef
42. Howard, S.J., Cerar, D., Anderson, M.J., Albarrag, A., Fisher, M.C., Pasqualotto, A.C., Laverdiere, M., Arendrup, M.C., Perlin, D.S., and Denning, D.W. 2009. Frequency and evolution of azole resistance in / Aspergillus fumigatus associated with treatment failure. / Emerging Infect. Dis. 15, 1068鈥?076. CrossRef
43. Hu, W., Sillaots, S., Lemieux, S., Davison, J., Kauffman, S., Breton, A., Linteau, A., Xin, C., Bowman, J., Becker, J., et al. 2007. Essential gene identification and drug target prioritization in / Aspergillus fumigatus. / PLoS Pathog. 3, e24. CrossRef
44. Kikuchi, K., Watanabe, A., Ito, J., Oku, Y., Wuren, T., Taguchi, H., Yarita, K., Muraosa, Y., Yahiro, M., Yaguchi, T., et al. 2014. Antifungal susceptibility of / Aspergillus fumigatus clinical isolates collected from various areas in Japan. / J. Infect. Chemother. 20, 336鈥?38. CrossRef
45. Krishnan, K. and Askew, D.S. 2014. The fungal UPR: a regulatory hub for virulence traits in the mold pathogen / Aspergillus fumigatus. / Virulence 5, 334鈥?40. CrossRef
46. Krishnan, K., Feng, X., Powers-Fletcher, M.V., Bick, G., Richie, D.L., Woollett, L.A., and Askew, D.S. 2013. Effects of a defective endoplasmic reticulum-associated degradation pathway on the stress response, virulence, and antifungal drug susceptibility of the mold pathogen / Aspergillus fumigatus. / Eukaryot. Cell 12, 512鈥?19. CrossRef
47. Lamoth, F., Juvvadi, P.R., Fortwendel, J.R., and Steinbach, W.J. 2012. Heat shock protein 90 is required for conidiation and cell wall integrity in / Aspergillus fumigatus. / Eukaryotic Cell 11, 1324鈥?332. CrossRef
48. Lamoth, F., Juvvadi, P.R., Gehrke, C., and Steinbach, W.J. 2013. / In vitro activity of calcineurin and heat shock protein 90 inhibitors against / Aspergillus fumigatus azole- and echinocandin-resistant strains. / Antimicrob. Agents Chemother. 57, 1035鈥?039. CrossRef
49. Lamoth, F., Juvvadi, P.R., Soderblom, E.J., Moseley, M.A., Asfaw, Y.G., and Steinbach, W.J. 2014a. Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in / Aspergillus fumigatus. Antimicrob. / Agents Chemother. 58, 1889鈥?896. CrossRef
50. Lamoth, F., Juvvadi, P.R., and Steinbach, W.J. 2014b. Heat shock protein 90 (Hsp90): A novel antifungal target against / Aspergillus fumigatus. / Crit. Rev. Microbiol. 22, 1鈥?2. CrossRef
51. Lamping, E., Baret, P.V., Holmes, A.R., Monk, B.C., Goffeau, A., and Cannon, R.D. 2010. Fungal PDR transporters: Phylogeny, topology, motifs and function. / Fungal Genet. Biol. 47, 127鈥?42. CrossRef
52. Lass-Fl枚rl, C., Cuenca-Estrella, M., Denning, D.W., and Rodriguez-Tudela, J.L. 2006. Antifungal susceptibility testing in / Aspergillus spp. according to EUCAST methodology. / Med. Mycol. 44, 319鈥?25. CrossRef
53. Lass-Florl, C., Perkhofer, S., and Mayr, A. 2010. / In vitro susceptibility testing in fungi: a global perspective on a variety of methods. / Mycoses 53, 1鈥?1. CrossRef
54. Lelievre, L., Groh, M., Angebault, C., Maherault, A.C., Didier, E., and Bougnoux, M.E. 2013. Azole resistant / Aspergillus fumigatus: an emerging problem. / Med. Mal. Infect. 43, 139鈥?45. CrossRef
55. Liu, F., Pu, L., Zheng, Q., Zhang, Y., Gao, R., Xu, X., Zhang, S., and Lu, L. 2014. Calcium signaling mediates antifungal activity of triazole drugs in the Aspergilli. / Fungal Genet. Biol. Doi: 10.1016/j.fgb.2014.12.005 .
56. Mayr, A. and Lass-Florl, C. 2011. Epidemiology and antifungal resistance in invasive Aspergillosis according to primary disease: review of the literature. / Eur. J. Med. Res. 16, 153鈥?57. CrossRef
57. Mellado, E., Garcia-Effron, G., Alcazar-Fuoli, L., Cuenca-Estrella, M., and Rodriguez-Tudela, J.L. 2004. Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of / Aspergillus fumigatus are responsible for resistance / in vitro to azole antifungal drugs. / Antimicrob. Agents Chemother. 48, 2747鈥?750. CrossRef
58. Mellado, E., Garcia-Effron, G., Alcazar-Fuoli, L., Melchers, W.J.G., Verweij, P.E., Cuenca-Estrella, M., and Rodriguez-Tudela, J.L. 2007. A new / Aspergillus fumigatus resistance mechanism conferring / in vitro cross-resistance to azole antifungals involves a combination of / cyp51A alterations. / Antimicrob. Agents Chemother. 51, 1897鈥?904. CrossRef
59. Mellado, E., Garcia-Effron, G., Buitrago, M.J., Alcazar-Fuoli, L., Cuenca-Estrella, M., and Rodriguez-Tudela, J.L. 2005. Targeted gene disruption of the 14-alpha sterol demethylase ( / cyp51A) in / Aspergillus fumigatus and its role in azole drug susceptibility. / Antimicrob. Agents Chemother. 49, 2536鈥?538. CrossRef
60. Messer, S.A., Diekema, D.J., Hollis, R.J., Boyken, L.B., Tendolkar, S., Kroeger, J., and Pfaller, M.A. 2007. Evaluation of disk diffusion and Etest compared to broth microdilution for antifungal susceptibility testing of posaconazole against clinical isolates of filamentous fungi. / J. Clin. Microbiol. 45, 1322鈥?324. CrossRef
61. Montiel, M.D., Lee, H.A., and Archer, D.B. 2006. Evidence of RIP (repeat-induced point mutation) in transposase sequences of / Aspergillus oryzae. / Fungal Genet. Biol. 43, 439鈥?45. CrossRef
62. Morschhauser, J. 2010. Regulation of multidrug resistance in pathogenic fungi. / Fungal Genet. Biol. 47, 94鈥?06. CrossRef
63. Nascimento, A.M., Goldman, G.H., Park, S., Marras, S.A.E., Delmas, G., Oza, U., Lolans, K., Dudley, M.N., Mann, P.A., and Perlin, D.S. 2003. Multiple resistance mechanisms among / Aspergillus fumigatus mutants with high-level resistance to itraconazole. / Antimicrob. Agents Chemother. 47, 1719鈥?726. CrossRef
64. Parker, J.E., Warrilow, A.G., Price, C.L., Mullins, J.G., Kelly, D.E., and Kelly, S.L. 2014. Resistance to antifungals that target Cyp51. / J. Chem. Biol. 7, 143鈥?61. CrossRef
65. Paul, S., Diekema, D., and Moye-Rowley, W.S. 2013. Contributions of / Aspergillus fumigatus ATP-binding cassette transporter proteins to drug resistance and virulence. / Eukaryotic Cell 12, 1619鈥?628. CrossRef
66. Pfaller, M., Boyken, L., Hollis, R., Kroeger, J., Messer, S., Tendolkar, S., and Diekema, D. 2011. Use of epidemiological cutoff values to examine 9-year trends in susceptibility of / Aspergillus species to the triazoles. / J. Clin. Microbiol. 49, 586鈥?90. CrossRef
67. Pfaller, M.A., Messer, S.A., Mills, K., and Bolmstrom, A. 2000. / In vitro susceptibility testing of filamentous fungi: comparison of Etest and reference microdilution methods for determining itraconazole MICs. / J. Clin. Microbiol. 38, 3359鈥?361.
68. Posteraro, B. and Sanguinetti, M. 2014. The future of fungal susceptibility testing. / Future Microbiol. 9, 947鈥?67. CrossRef
69. Posteraro, B., Torelli, R., De Carolis, E., Posteraro, P., and Sanguinetti, M. 2014. Antifungal susceptibility testing: current role from the clinical laboratory perspective. / Mediterr. J. Hematol. Infect. Dis. 6, e2014030. CrossRef
70. Prasad, R. and Rawal, M.K. 2014. Efflux pump proteins in antifungal resistance. / Front. Pharmacol. 5, 202. CrossRef
71. Prigitano, A., Venier, V., Cogliati, M., De Lorenzis, G., Esposto, M.C., and Tortorano, A.M. 2014. Azole-resistant / Aspergillus fumigatus in the environment of northern Italy, May 2011 to June 2012. / Euro Surveill. 19, 20747.
72. Qiao, J., Liu, W., and Li, R. 2010. Truncated Afyap1 attenuates antifungal susceptibility of / Aspergillus fumigatus to voriconazole and confers adaptation of the fungus to oxidative stress. / Mycopathologia 170, 155鈥?60. CrossRef
73. Rajendran, R., Mowat, E., McCulloch, E., Lappin, D.F., Jones, B., Lang, S., Majithiya, J.B., Warn, P., Williams, C., and Ramage, G. 2011. Azole resistance of / Aspergillus fumigatus biofilms is partly associated with efflux pump activity. / Antimicrob. Agents Chemother. 55, 2092鈥?097. CrossRef
74. Rath, P.M., Buchheidt, D., Spiess, B., Arfanis, E., Buer, J., and Steinmann, J. 2012. First reported case of azole-resistant / Aspergillus fumigatus due to the TR/L98H mutation in Germany. / Antimicrob. Agents Chemother. 56, 6060鈥?061. CrossRef
75. Richardson, M.D. 2005. Changing patterns and trends in systemic fungal infections. / J. Antimicrob. Chemother. 56 Suppl 1, i5鈥搃11. CrossRef
76. Seyedmousavi, S., Mouton, J.W., Melchers, W.J., Bruggemann, R.J., and Verweij, P.E. 2014. The role of azoles in the management of azole-resistant aspergillosis: from the bench to the bedside. / Drug Resist. Updat. 17, 37鈥?0. CrossRef
77. Shao, P.L., Huang, L.M., and Hsueh, P.R. 2007. Recent advances and challenges in the treatment of invasive fungal infections. / Int. J. Antimicrob. Agents 30, 487鈥?95. CrossRef
78. Shapiro, R.S., Robbins, N., and Cowen, L.E. 2011. Regulatory circuitry governing fungal development, drug resistance, and disease. / Microbiol. Mol. Biol. Rev. 75, 213鈥?67. CrossRef
79. Slaven, J.W., Anderson, M.J., Sanglard, D., Dixon, G.K., Bille, J., Roberts, I.S., and Denning, D.W. 2002. Increased expression of a novel / Aspergillus fumigatus ABC transporter gene, / atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate. / Fungal Genet. Biol. 36, 199鈥?06. CrossRef
80. Smialowska, A., Djupedal, I., Wang, J., Kylsten, P., Swoboda, P., and Ekwall, K. 2014. RNAi mediates post-transcriptional repression of gene expression in fission yeast Schizosaccharomyces pombe. / Biochem. Biophys. Res. Commun. 444, 254鈥?59. CrossRef
81. Snelders, E., Camps, S.M., Karawajczyk, A., Schaftenaar, G., Kema, G.H., van der Lee, H.A., Klaassen, C.H., Melchers, W.J., and Verweij, P.E. 2012. Triazole fungicides can induce cross-resistance to medical triazoles in / Aspergillus fumigatus. / PLoS One 7, e31801. CrossRef
82. Snelders, E., Karawajczyk, A., Schaftenaar, G., Verweij, P.E., and Melchers, W.J. 2010. Azole resistance profile of amino acid changes in / Aspergillus fumigatus Cyp51A based on protein homology modeling. / Antimicrob. Agents Chemother. 54, 2425鈥?430. CrossRef
83. Snelders, E., Karawajczyk, A., Verhoeven, R.J., Venselaar, H., Schaftenaar, G., Verweij, P.E., and Melchers, W.J. 2011. The structure-function relationship of the / Aspergillus fumigatuscyp51A L98H conversion by site-directed mutagenesis: the mechanism of L98H azole resistance. / Fungal Genet. Biol. 48, 1062鈥?070. CrossRef
84. Spiess, B., Postina, P., Reinwald, M., Cornely, O.A., Hamprecht, A., Hoenigl, M., Lass-Florl, C., Rath, P.M., Steinmann, J., Miethke, T., et al. 2014. Incidence of Cyp51 A key mutations in / Aspergillus fumigatus-a study on primary clinical samples of immunocompromised patients in the period of 1995鈥?013. / PLoS One 9, e103113. CrossRef
85. Steinbach, W.J., Reedy, J.L., Cramer, R.A. Jr., Perfect, J.R., and Heitman, J. 2007. Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections. / Nat. Rev. Microbiol. 5, 418鈥?30. CrossRef
86. Sun, N., Li, D., Fonzi, W., Li, X., Zhang, L., and Calderone, R. 2013. Multidrug-resistant transporter mdr1p-mediated uptake of a novel antifungal compound. / Antimicrob. Agents Chemother. 57, 5931鈥?939. CrossRef
87. Traunmuller, F., Popovic, M., Konz, K.H., Smolle-Juttner, F.M., and Joukhadar, C. 2011. Efficacy and safety of current drug therapies for invasive aspergillosis. / Pharmacology 88, 213鈥?24. CrossRef
88. van der Linden, J.W., Camps, S.M., Kampinga, G.A., Arends, J.P., Debets-Ossenkopp, Y.J., Haas, P.J., Rijnders, B.J., Kuijper, E.J., van Tiel, F.H., Varga, J., et al. 2013. Aspergillosis due to voriconazole highly resistant / Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles. / Clin. Infect. Dis. 57, 513鈥?20. CrossRef
89. van der Linden, J.W., Snelders, E., Kampinga, G.A., Rijnders, B.J., Mattsson, E., Debets-Ossenkopp, Y.J., Kuijper, E.J., Van Tiel, F.H., Melchers, W.J., and Verweij, P.E. 2011. Clinical implications of azole resistance in / Aspergillus fumigatus, The Netherlands, 2007鈥?009. / Emerg. Infect. Dis. 17, 1846鈥?854. CrossRef
90. van Ingen, J., van der Lee, H.A., Rijs, T.A., Zoll, J., Leenstra, T., Melchers, W.J., and Verweij, P.E. 2014. Azole, polyene and echinocandin MIC distributions for wild-type, TR34/L98H and TR46/Y121F/T289A / Aspergillus fumigatus isolates in the Netherlands. / J. Antimicrob. Chemother. 70, 178鈥?81. CrossRef
91. Vermeulen, E., Lagrou, K., and Verweij, P.E. 2013. Azole resistance in / Aspergillus fumigatus: a growing public health concern. / Curr. Opin. Infect. Dis. 26, 493鈥?00. CrossRef
92. Verweij, P.E., Howard, S.J., Melchers, W.J., and Denning, D.W. 2009. Azole-resistance in Aspergillus: proposed nomenclature and break-points. / Drug Resist. Updat. 12, 141鈥?47. CrossRef
93. Walsh, T.J., Anaissie, E.J., Denning, D.W., Herbrecht, R., Kontoyiannis, D.P., Marr, K.A., Morrison, V.A., Segal, B.H., Steinbach, W.J., Stevens, D.A., et al. 2008. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. / Clin. Infect. Dis. 46, 327鈥?60. CrossRef
94. Wang, D.Y., Gricourt, M., Arne, P., Thierry, S., Seguin, D., Chermette, R., Huang, W.Y., Dannaoui, E., Botterel, F., and Guillot, J. 2014. Mutations in the / Cyp51A gene and susceptibility to itraconazole in / Aspergillus fumigatus isolated from avian farms in France and China. / Poult. Sci. 93, 12鈥?5. CrossRef
95. Warrilow, A.G., Melo, N., Martel, C.M., Parker, J.E., Nes, W.D., Kelly, S.L., and Kelly, D.E. 2010. Expression, purification, and characterization of / Aspergillus fumigatus sterol 14-alpha demethylase (Cyp51) isoenzymes A and B. / Antimicrob. / Agents Chemother. 54, 4225鈥?234. CrossRef
96. Willger, S.D., Puttikamonkul, S., Kim, K.H., Burritt, J.B., Grahl, N., Metzler, L.J., Barbuch, R., Bard, M., Lawrence, C.B., and Cramer, R.A. Jr. 2008. A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in / Aspergillus fumigatus. / PLoS Pathog. 4, e1000200. CrossRef
97. Xiao, L., Madison, V., Chau, A.S., Loebenberg, D., Palermo, R.E., and McNicholas, P.M. 2004. Three-dimensional models of wildtype and mutated forms of cytochrome P450 14伪-sterol demethylases from / Aspergillus fumigatus and / Candida albicans provide insights into posaconazole binding. / Antimicrob. Agents Chemother. 48, 568鈥?74. CrossRef - 刊物主题：Microbiology;
- 出版者：Springer Netherlands
- ISSN：1976-3794
文摘
The growing use of immunosuppressive therapies has resulted in a dramatic increased incidence of invasive fungal infections (IFIs) caused by Aspergillus fumigatus, a common pathogen, and is also associated with a high mortality rate. Azoles are the primary guideline-recommended therapy agents for first-line treatment and prevention of IFIs. However, increased azole usage in medicinal and agricultural settings has caused azole-resistant isolates to repeatedly emerge in the environment, resulting in a significant threat to human health. In this review, we present and summarize current research on the resistance mechanisms of azoles in A. fumigatus as well as efficient susceptibility testing methods. Moreover, we analyze and discuss the putative clinical (bedside) indication of these findings from bench work.