Serum Surfactant Protein D (SP-D) is a Prognostic Marker of Poor Outcome in Patients with A/H1N1 Virus Infection

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• 作者：Carlos Delgado ; Edgar Kr?tzsch ; Luis A. Jiménez-Alvarez ; Gustavo Ramírez-Martínez…
• 关键词：Surfactant protein D (SP ; D) ; A/H1N1 virus ; Influenza ; ARDS ; Mortality ; Biomarker
• 刊名：Lung
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：193
• 期：1
• 页码：25-30
• 全文大小：295 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pneumology and Respiratory System
  
• 出版者：Springer New York
• ISSN：1432-1750

文摘

Introduction Surfactant protein D (SP-D) plays an important role in the innate responses against pathogens and its production is altered in lung disorders. Methods We studied the circulating levels of SP-D in 37 patients with acute respiratory distress syndrome due to the A/H1N1 virus infection and in 40 healthy controls. Cox logistic regression models were constructed to explore the association of SP-D levels and risk of death. Results Mortality rate after a 28-day was 32.42?%. Significant higher levels of SP-D were detected in A/H1N1 patients with fatal outcome (p?p?=?0.043). Conclusions Our results revealed that higher circulating levels of SP-D are associated with higher mortality risk in critically ill A/H1N1 patients. SP-D might be a predictive factor of poor outcomes in viral pneumonia.