Heightened stress response and cognitive impairment after repeated neonatal sevoflurane exposures might be linked to excessive GABAAR-mediated depolarization
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- 作者：Guanghai Liu ; Tiangui Zhu ; Aihua Zhang ; Feng Li ; Weidong Qian…
- 关键词：Repeated neonatal sevoflurane exposures ; Endocrine response ; Corticosterone ; Bumetanide ; γ ; Aminobutyric acid type A receptor
- 刊名：Journal of Anesthesia
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：30
- 期：5
- 页码：834-841
- 全文大小：636 KB
- 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Anesthesiology - 出版者：Springer Japan
- ISSN：1438-8359
- 卷排序：30
文摘
ObjectiveChildren with repeated exposures to anesthesia at an early age are at an increased risk of cognitive impairment. Data in the literature link increased developmental depolarizing γ-aminobutyric acid (GABA) type A receptor (GABAAR) at younger age to neurodevelopmental disorders. Here we investigated the involvement of GABAergic signaling during development in mediating the adverse effects of repeated sevoflurane exposures.