Inflammatory pseudotumors of the liver: experience of 114 cases

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• 作者：Xiaoyu Yang ; Junjun Zhu ; Ewelina Biskup ; Fengfeng Cai ; Aijun Li
• 关键词：Hepatic inflammatory ; Pseudotumors ; Diagnosis ; Imaging characters ; Treatment
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：36
• 期：7
• 页码：5143-5148
• 全文大小：425 KB
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• 作者单位：Xiaoyu Yang (1)
  Junjun Zhu (2)
  Ewelina Biskup (3)
  Fengfeng Cai (4)
  Aijun Li (1)
  
  1. Division of Special Treatment II, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China
  2. Division of Interventional Radiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China
  3. Department of Oncology, University Hospital of Basel, Basel, 4055, Switzerland
  4. Department of Breast Surgery, Yangpu Hospital, Tongji University, Shanghai, 200090, China
  
• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

Hepatic inflammatory pseudotumors (HIPT) are rare benign neoplasms with unknown etiology and a great potential for mimicry, challenging diagnostics, and treatment features. The aim of the study was to retrospectively analyze the imaging, pathological, and clinical features of HIPT in our large cohort of patients in order to increase the understanding and suggest a scoring system for treatment approaches. Retrospective study analyzed 114 HIPT cases recorded from July 2006 to July 2012, when surgery was performed. Data were compared with chi-square test. In our study population, the mean age was 53.14?±-0.98?years, with 69 male and 45 female patients. Most presented symptoms were abdominal pain (59/144, 41.0?%), fever (48/114, 42.1?%), abdominal distension (35/144, 24.3?%), and weight loss (12/144, 8.3?%). Laboratory examinations were normal. Sixteen cases were HBsAg positive and 8 had liver cirrhosis. Most of the tumors were located in the right lobe (79/114, 69.3?%), 33 in the left lobe, and 2 in the caudal lobe. Three imaging modalities, such as ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI), were compared and showed significant differences in sensitivity and sensibility. HIPT diagnostics are challenging, and conservative treatment should be prioritized as soon as the diagnosis is made. CT and MRI seem to have comparable diagnostic sensitivity. We propose a guideline for consideration of operative approach.