Molecular Imaging of Macrophages in Atherosclerosis

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• 作者：Elena Aikawa (1)
  Sophie E. P. New (1)
  Tetsuro Miyazaki (1)
  Daiju Fukuda (1)
  Masanori Aikawa (1) (2)
  
• 关键词：Macrophages ; Atherosclerosis ; Imaging ; Inflammation ; Calcification ; Cardiac molecular imaging
• 刊名：Current Cardiovascular Imaging Reports
• 出版年：2012
• 出版时间：February 2012
• 年：2012
• 卷：5
• 期：1
• 页码：45-52
• 全文大小：339KB
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• 作者单位：Elena Aikawa (1)
  Sophie E. P. New (1)
  Tetsuro Miyazaki (1)
  Daiju Fukuda (1)
  Masanori Aikawa (1) (2)
  
  1. Cardiovascular Division, Department of Medicine, Brigham and Women鈥檚 Hospital, Harvard Medical School, Boston, MA, 02115, USA
  2. Center for Excellence in Vascular Biology, Brigham and Women鈥檚 Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB741J, Boston, MA, 02115, USA
  

文摘

Macrophages contribute to the initiation, progression, and acute complications of atherosclerosis. Imaging of macrophages during disease progression provides new insights into the mechanisms of atherosclerosis. Advanced imaging techniques may serve as sensitive diagnostic tools for early detection of the disease to identify individuals with subclinical plaques and to prevent devastating complications. Furthermore, molecular imaging may monitor the effects of therapeutic interventions. Development of fully integrated molecular imaging requires dynamic multidisciplinary collaboration.