Association of Interleukin-6-572C/G Gene Polymorphism and Serum or Cerebrospinal Fluid Interleukin-6 Level with Enterovirus 71 Encephalitis in Chinese Han Patients with Hand, Foot, and Mouth Disease
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- 作者：Aiyun Yuan ; Jian Li ; Peipei Liu ; Zongbo Chen ; Mei Hou ; Jinju Wang…
- 关键词：enterovirus 71 ; encephalitis ; interleukin ; 6 ; polymorphism
- 刊名：Inflammation
- 出版年：2015
- 出版时间：April 2015
- 年：2015
- 卷：38
- 期：2
- 页码：728-735
- 全文大小：258 KB
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文摘
Interleukin-6 (IL-6), as one of pro-inflammatory cytokines, plays a key role in Enterovirus 71 (EV71) encephalitis. We investigated the association of IL-6-572C/G polymorphism and serum or cerebrospinal fluid (CSF) IL-6 level with EV71 encephalitis in patients with hand, foot, and mouth disease (HFMD). This study was carried out in 59 Chinese Han patients with EV71 encephalitis, 128 EV71-related HFMD without complications, and 232 controls. The IL-6-572C/G polymorphism was detected by polymerase chain reaction-restricted fragment length polymorphism gene analysis. Serum or CSF IL-6 levels were determined using a commercial enzyme-linked immunosorbent assay. The patients with EV71 encephalitis had a higher frequency of IL-6-572GG/GC genotype compared to the patients with EV71-related HFMD without encephalitis complications (40.7 vs. 15.6?%, odds ratio (OR)--.70, 95?% confidence interval (CI)--.83-.50, p--.001). Similarly, the frequency of IL-6-572 G allele among the patients with EV71 encephalitis was also higher than that of patients with EV71-related HFMD without encephalitis complications (23.7 vs. 8.6?%, OR--.31, 95?% CI--.80-.08, p--.001). Serum IL-6 levels in G carries (CG + GG) (195.1?±-1.8?pg/ml) elevated significantly compared to CC homozygotes (167.7?±-.7?pg/ml) in EV71-infected patients (p--.001), but no significant differences were observed in CSF IL-6 levels among different genotypes in patients with EV71 encephalitis. Furthermore, G carriers (GG + GC) (10.6?±-.29?mg/l) had significantly higher blood CRP levels compared to CC homozygotes (9.31?±-.93?mg/l) in patients with EV71 encephalitis (p--.005). These findings suggested that IL-6-572 G allele was significantly associated with the susceptibility to EV71 encephalitis in Chinese Han patients, and IL-6-572 G allele might elevate the risk to EV71 encephalitis.