Catheter Ablation for Long-Standing Persistent Atrial Fibrillation in Patients Who Have Failed Electrical Cardioversion
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  • 作者:Fei Lü (1) (2)
    Wayne O. Adkisson (1)
    Taibo Chen (1)
    Baris Akdemir (1)
    David G. Benditt (1)
  • 关键词:Long ; standing persistent atrial fibrillation ; Stepwise ablation ; Complex fractionated atrial electrogram ; Cardioversion ; Pulmonary vein
  • 刊名:Journal of Cardiovascular Translational Research
  • 出版年:2013
  • 出版时间:April 2013
  • 年:2013
  • 卷:6
  • 期:2
  • 页码:278-286
  • 全文大小:234KB
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  • 作者单位:Fei Lü (1) (2)
    Wayne O. Adkisson (1)
    Taibo Chen (1)
    Baris Akdemir (1)
    David G. Benditt (1)

    1. Cardiac Arrhythmia Center, Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    2. Director of Cardiac Electrophysiology Laboratory, University of Minnesota Medical School, MMC 508, 420 Delaware Street SE, Minneapolis, MN, 55455, USA
  • ISSN:1937-5395
文摘
Ablation outcomes in 22 consecutive long-standing persistent atrial fibrillation (LPAF) patients with failed direct current cardioversion (DCCV; group 1) were compared with findings in 22 consecutive LPAF patients who had successful DCCV (control 1) and 22 consecutive patients with paroxysmal atrial fibrillation (AF; control 2). All patients underwent a stepwise progressive ablation protocol (pulmonary vein isolation, ablation of complex fractionated atrial electrogram, and repeat ablation of any induced atrial tachycardias). Over 18-month follow-up, 59?% of group 1 patients remained in sinus rhythm without recurrent AF, compared to 64 % and 77?% in controls 1 and 2, respectively. The procedure time was longer in LPAF with a higher procedure complication risk in these 44 LPAF patients (5 % vs. 0?%) than in patients with paroxysmal AF. Our data suggest that catheter ablation provides a practical treatment option with moderate efficacy for restoring sinus rhythm in LPAF patients after failed DCCV.

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