Vitreous Fluid Levels of ?-Amyloid_(1?2) and Tau in Patients with Retinal Diseases

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• 作者：Shinji Yoneda ; Hideaki Hara ; Akira Hirata ; Mikiko Fukushima ; Yasuya Inomata and Hidenobu Tanihara
• 关键词：amyloid ; diabetic retinopathy ; glaucoma ; tau ; vitreous fluid
• 刊名：Japanese Journal of Ophthalmology
• 出版年：2005
• 出版时间：March 2005
• 年：2005
• 卷：49
• 期：2
• 页码：106-108
• 全文大小：123 KB

文摘

Purpose A decrease in -amyloid_1–42 (A42) and an increase in tau in the cerebrospinal fluid are reported to be characteristic phenomena in Alzheimers disease patients. To test the idea that A42 and tau contribute to the development of retinal diseases, we measured A42 and tau concentrations in the vitreous fluid from patients with macular hole (n = 13), diabetic retinopathy (n = 15), or glaucoma concurrent with other ocular diseases (n = 8).