Variants in the interleukin-1 alpha and beta genes, and the risk for periodontal disease in dogs

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• 作者：C. ALBUQUERQUE ; F. MORINHA ; J. MAGALHÃES ; J. REQUICHA ; I. DIAS…
• 关键词：periodontal disease ; dog ; genetic variations ; interleukin ; 1α ; interleukin ; 1β
• 刊名：Journal of Genetics
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：94
• 期：4
• 页码：651-659
• 全文大小：1,441 KB
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• 作者单位：C. ALBUQUERQUE (1) (2)
  F. MORINHA (1) (3)
  J. MAGALHÃES (1)
  J. REQUICHA (2)
  I. DIAS (2) (3) (4)
  H. GUEDES-PINTO (1)
  E. BASTOS (1)
  C. VIEGAS (2) (3) (4)
  
  1. Department of Genetics and Biotechnology, University of Trás-os-Montes e Alto Douro (UTAD), Quinta de Prados, P. O. Box 1013, 5000-801, Vila Real, Portugal
  2. Department of Veterinary Sciences, University of Trás-os-Montes e Alto Douro (UTAD), Quinta de Prados, P. O. Box 1013, 5000-801, Vila Real, Portugal
  3. Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes e Alto Douro (UTAD), Quinta de Prados, P. O. Box 1013, 5000-801, Vila Real, Portugal
  4. 3B’s Research Group–Biomaterials, Biodegradables and Biomimetics, ICVS/3B’s–PT Government Associate Laboratory, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, 4805-017, Barco GMR, Portugal
  
• 刊物主题：Life Sciences, general; Microbial Genetics and Genomics; Plant Genetics & Genomics; Animal Genetics and Genomics; Evolutionary Biology;
• 出版者：Springer India
• ISSN：0973-7731

文摘

Elevated levels of interleukin-1 (IL-1) have been shown to amplify the inflammatory response against periodontopathogenic bacteria. In humans, polymorphisms in the IL1A and IL1B genes are the most well-studied genetic polymorphisms associated with periodontal disease (PD). In contrast to human, there is a lack of knowledge on the genetic basis of canine PD. A case–control study was conducted in which a molecular analysis of dog IL1A and IL1B genes was performed. Of the eight genetic variants identified, seven in IL1A gene and one in IL1B gene, IL1A/1_g.388A >C and IL1A/1_g.521T >A showed statistically significant differences between groups (adjusted OR (95% CI): 0.15 (0.03–0.76), P= 0.022; 5.76 (1.03–32.1), P= 0.046, respectively). It suggests that in the studied population the IL1A/1_g.388C allele is associated with a decreased PD risk, whereas the IL1A/1_g.521A allele can confer an increased risk. Additionally, the IL1A/2_g.515G >T variation resulted in a change of amino acid, i.e. glycine to valine. In silico analysis suggests that this change can alter protein structure and function, predicting it to be deleterious or damaging. This work suggests that IL1 genetic variants may be important in PD susceptibility in canines. Keywords periodontal disease dog genetic variations interleukin-1α interleukin-1β