Evaluation of clinico-pathological features and Helicobacter pylori infection in gastric inflammatory fibroid polyps

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• 作者：Andreia Albuquerque (1)
  Elisabete Rios (2) (3) (4)
  Fátima Carneiro (2) (3) (4)
  Guilherme Macedo (1)
  
• 关键词：Gastric ; Inflammatory fibroid polyps ; Helicobacter pylori ; Mucosa ; Onion skin
• 刊名：Virchows Archiv
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：465
• 期：6
• 页码：643-647
• 全文大小：142 KB
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• 作者单位：Andreia Albuquerque (1)
  Elisabete Rios (2) (3) (4)
  Fátima Carneiro (2) (3) (4)
  Guilherme Macedo (1)
  
  1. Department of Gastroenterology, Centro Hospitalar S?o Jo?o, 4200-319, Porto, Portugal
  2. Department of Pathology, Centro Hospitalar S?o Jo?o, Porto, Portugal
  3. Department of Pathology and Oncology, Faculty of Medicine—University of Porto, Porto, Portugal
  4. Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
  
• ISSN：1432-2307

文摘

Inflammatory fibroid polyps are rare mesenchymal lesions. The frequency of Helicobacter pylori infection in the gastric mucosa overlying inflammatory fibroid polyps and its relation with the histologic features of the polyps are undetermined. The clinico-pathological features of inflammatory fibroid polyps, the frequency of Helicobacter pylori infection in the overlying gastric mucosa, and its putative impact on the phenotype of the polyps were evaluated. Gastric inflammatory fibroid polyps diagnosed in our Hospital from 1998 to 2012 were reviewed and the histological. The histological sections were stained with hematoxylin and eosin and modified Giemsa for the evaluation of Helicobacter pylori infection. Inconclusive cases were further analyzed by immunohistochemistry with anti-Helicobacter pylori antibody. Diagnosis was confirmed in 54 polyps, 85?% developed in females, mean age 63?±-1?years. Most polyps were sessile (74?%), with a mean size of 15?±-2?mm, 96?% were located in the antrum and 85?% were removed by snare polypectomy. Helicobacter pylori infection was identified in 48?% of the polyps. Most inflammatory fibroid polyps developed in the submucosa, and mucosal extension was observed in 96?% of the cases. Chronic gastritis was observed in all cases (63?% with activity, 31?% with intestinal metaplasia, and 61?% with foveolar hyperplasia). Erosion and ulceration of the overlying gastric mucosa was observed in 48?% and 11?% of the polyps, respectively. Onion skin features were present in 52?% of the polyps and were more frequently observed in cases without evidence of Helicobacter pylori infection. Background changes in gastric mucosa were not distinctive according to Helicobacter pylori infection. Chronic atrophic gastritis with intestinal metaplasia was associated with the presence of perivascular onion skin lesions. To our knowledge, this is the second largest series of gastric inflammatory fibroid polyps. Helicobacter pylori infection was identified in about half of the cases and was associated with a lower frequency of onion skin features in the polyps.