Hyperaldosteronism: How to Discriminate Among Different Disease Forms?

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• 作者：Valentina Crudo ; Silvia Monticone…
• 关键词：Primary aldosteronism ; Aldosterone producing adenoma ; Adrenal vein sampling ; Secondary hypertension
• 刊名：High Blood Pressure & Cardiovascular Prevention
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：23
• 期：3
• 页码：203-208
• 全文大小：425 KB
• 刊物主题：Cardiology; Pharmacotherapy;
• 出版者：Springer International Publishing
• ISSN：1179-1985
• 卷排序：23

文摘

Primary aldosteronism (PA), characterized by the inappropriate and abnormal adrenal secretion of aldosterone, is the most common cause of secondary hypertension. PA has been shown to increase cardiovasular and cerebrovascular risks in comparison with essential hypertension. PA is a multi-faceted disease, which comprises unilateral forms, benefitting from surgical treatment, and bilateral forms, which are the best managed medically. PA is more frequently sporadic, but in some cases, it displays a familial transmission pattern. For these reasons, it is important to diagnose PA early on and correctly distinguish and manage its different forms. In this review, we analyze the different forms of PA, with attention on the diagnostic pathway and the genetics of the disease.