The Coordination Abilities of New Cyclic Analogs of Somatostatin
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- 作者：Aleksandra Marciniak ; Marek Cebrat…
- 关键词：Somatostatin ; Somatostatin analogs ; Copper complexes ; Potentiometric measurements ; Spectroscopy
- 刊名：International Journal of Peptide Research and Therapeutics
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：23
- 期：1
- 页码：135-143
- 全文大小：876KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biochemistry, general; Animal Anatomy / Morphology / Histology; Polymer Sciences; Pharmaceutical Sciences/Technology; Pharmacology/Toxicology; Molecular Medicine;
- 出版者：Springer Netherlands
- ISSN：1573-3904
- 卷排序：23
文摘
Two new somatostatin analogs with a characteristic part of the sequence -c(Cys-Phe-Trp-Lys-Thr-Cys)- and with two histidine and two aspartic acid moieties in their structures were synthesized and analyzed in terms of their coordination abilities with copper (II) ions. Both peptides bind Cu(II) effectively. Ligands form 4N complexes with \(\left\{ {{\text{N}}_{\text{Im}} ,{ 3} {\text{N}}_{\text{amide}}^{ - } } \right\}\) binding mode in a basic range of pH. But in spite of very similar sequences of the two peptides a significant difference in the effectiveness of the binding of copper (II) ions was observed.