Antiangiogenic therapy of brain tumors: the role of bevacizumab
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- 作者：Elisa Trevisan (1)
Luca Bertero (1)
Chiara Bosa (1)
Michela Magistrello (1)
Alessia Pellerino (1)
Roberta Rudà (1)
Riccardo Soffietti (1) - 关键词：Glioblastoma ; High ; grade glioma ; Angiogenesis ; VEGF ; Bevacizumab
- 刊名：Neurological Sciences
- 出版年：2014
- 出版时间：April 2014
- 年：2014
- 卷：35
- 期：4
- 页码：507-514
- 全文大小：560 KB
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Luca Bertero (1)
Chiara Bosa (1)
Michela Magistrello (1)
Alessia Pellerino (1)
Roberta Rudà (1)
Riccardo Soffietti (1)
1. Division of Neuro-Oncology, Department of Neuroscience, University and AO Città della Salute e della Scienza, Via Cherasco, 15, 10126, Turin, Italy - ISSN：1590-3478
文摘
Angiogenesis is one of the hallmarks of cancer, including brain tumors. Malignant gliomas have the highest degree of vascular proliferation among solid tumors; thus, angiogenic pathways represent an attractive target to interfere with tumor growth. Up to date VEGF pathway targeting with specific drugs has yielded interesting therapeutics results. In particular bevacizumab, a monoclonal antibody against VEGF-A, has shown clinical activity in malignant gliomas, especially glioblastomas, in terms of a high response rate on MRI and a significant increase in progression-free survival.