Applying polygenic risk scores to postpartum depression

详细信息    查看全文

• 作者：Enda M. Byrne (1) (5)
  Tania Carrillo-Roa (1) (5)
  Brenda W. J. H. Penninx (2)
  Hannah M. Sallis (10) (3)
  Alexander Viktorin (4)
  Brett Chapman (5)
  Anjali K. Henders (5)
  Michele L. Pergadia (6)
  Andrew C. Heath (6)
  Pamela A. F. Madden (6)
  Patrick F. Sullivan (7)
  Lynn Boschloo (2)
  Gerard van Grootheest (2)
  George McMahon (10) (3)
  Debbie A. Lawlor (10) (3)
  Mikael Landén (4)
  Paul Lichtenstein (4)
  Patrik K. E. Magnusson (4)
  David M. Evans (10) (11) (3)
  Grant W. Montgomery (5)
  Dorret I. Boomsma (8)
  Nicholas G. Martin (5)
  Samantha Meltzer-Brody (9)
  Naomi R. Wray (1)
  Psychiatric Genomic Consortium Major Depressive Disorder Working Group
  
• 关键词：Depression ; Postpartum ; Bipolar
• 刊名：Archives of Women's Mental Health
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：17
• 期：6
• 页码：519-528
• 全文大小：368 KB
• 参考文献：1. Andrews-Fike C (1999) A review of postpartum depression. Prim Care Companion J Clin Psychiatry 1:9-4 CrossRef
  2. Boomsma DI, de Geus EJ, Vink JM, Stubbe JH, Distel MA, Hottenga JJ, Posthuma D, van Beijsterveldt TC, Hudziak JJ, Bartels M, Willemsen G (2006) Netherlands Twin Register: from twins to twin families. Twin Res Hum Genet 9:849-57 CrossRef
  3. Boomsma DI, Willemsen G, Sullivan PF, Heutink P, Meijer P, Sondervan D, Kluft C, Smit G, Nolen WA, Zitman FG, Smit JH, Hoogendijk WJ, van Dyck R, de Geus EJ, Penninx BW (2008) Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects. Eur J Hum Genet 16:335-42 CrossRef
  4. Britton JR (2007) Postpartum anxiety and breast feeding. J Reprod Med 52:689-95
  5. Cox JL, Holden JM, Sagovsky R (1987) Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. Br J Psychiatry 150:782-86 CrossRef
  6. Cross-Disorder Group of the Psychiatric Genomics, Lee C, Ripke SH, Neale S, Faraone BM, Purcell SV, Perlis SM, Mowry RH, Thapar BJ, Goddard A, Witte ME, Absher JS, Agartz D, Akil I, Amin H, Andreassen F, Anjorin OA, Anney A, Anttila R, Arking V, Asherson DE, Azevedo P, Backlund MH, Badner L, Bailey JA, Banaschewski AJ, Barchas T, Barnes JD, Barrett MR, Bass TB, Battaglia N, Bauer A, Bayes M, Bellivier M, Berrettini SE, Betancur W, Bettecken C, Biederman T, Binder J, Black EB, Blackwood DW, Bloss DH, Boehnke CS, Boomsma M, Breen DI, Breuer G, Bruggeman R, Cormican R, Buccola P, Buitelaar NG, Bunney JK, Buxbaum WE, Byerley JD, Byrne WF, Caesar EM, Cahn S, Cantor W, Casas RM, Chakravarti M, Chambert A, Choudhury K, Cichon S, Cloninger CR, Collier DA, Cook EH, Coon H, Cormand B, Corvin A, Coryell WH, Craig DW, Craig IW, Crosbie J, Cuccaro ML, Curtis D, Czamara D, Datta S, Dawson G, Day R, de Geus EJ, Degenhardt F, Djurovic S, Donohoe GJ, Doyle AE, Duan J, Dudbridge F, Duketis E, Ebstein RP, Edenberg HJ, Elia J, Ennis S, Etain B, Fanous A, Farmer AE, Ferrier IN, Flickinger M, Fombonne E, Foroud T, Frank J, Franke B (2013) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 45:984-4 CrossRef
  7. Dudbridge F (2013) Power and predictive accuracy of polygenic risk scores. PLoS Genet 9:e1003348 CrossRef
  8. Flynn HA, Davis M, Marcus SM, Cunningham R, Blow FC (2004) Rates of maternal depression in pediatric emergency department and relationship to child service utilization. Gen Hosp Psychiatry 26:316-22 CrossRef
  9. Fraser A, Macdonald-Wallis C, Tilling K, Boyd A, Golding J, Davey Smith G, Henderson J, Macleod J, Molloy L, Ness A, Ring S, Nelson SM, Awlor DA (2013) Cohort profile: the Avon longitudinal study of parents and children: ALSPAC mothers cohort. Int J Epidemiol 42:97-10 CrossRef
  10. Freeman MP, Smith KW, Freeman SA, Mcelroy SL, Kmetz GE, Wright R, Keck PE Jr (2002) The impact of reproductive events on the course of bipolar disorder in women. J Clin Psychiatry 63:284-87 CrossRef
  11. Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T (2005) Perinatal depression—a systematic review of prevalence and incidence. Obstet Gynecol 106:1071-083 CrossRef
  12. Gaynes BN, Gavin N, Meltzer-Brody S, Lohr KN, Swinson T, Gartlehner G, Brody S, Miller WC (2005) Perinatal depression: prevalence, screening accuracy, and screening outcomes. Evid Rep Technol Assess Summ 119:1-
  13. Ghaemi SN, Hsu DJ, Ko JY, Baldassano CF, Kontos NJ, Goodwin FK (2004) Bipolar spectrum disorder: a pilot study. Psychopathology 37:222-26 CrossRef
  14. Kendell RE, Chal
• 作者单位：Enda M. Byrne (1) (5)
  Tania Carrillo-Roa (1) (5)
  Brenda W. J. H. Penninx (2)
  Hannah M. Sallis (10) (3)
  Alexander Viktorin (4)
  Brett Chapman (5)
  Anjali K. Henders (5)
  Michele L. Pergadia (6)
  Andrew C. Heath (6)
  Pamela A. F. Madden (6)
  Patrick F. Sullivan (7)
  Lynn Boschloo (2)
  Gerard van Grootheest (2)
  George McMahon (10) (3)
  Debbie A. Lawlor (10) (3)
  Mikael Landén (4)
  Paul Lichtenstein (4)
  Patrik K. E. Magnusson (4)
  David M. Evans (10) (11) (3)
  Grant W. Montgomery (5)
  Dorret I. Boomsma (8)
  Nicholas G. Martin (5)
  Samantha Meltzer-Brody (9)
  Naomi R. Wray (1)
  Psychiatric Genomic Consortium Major Depressive Disorder Working Group
  
  1. Queensland Brain Institute, The University of Queensland, Upland Road, St. Lucia, Brisbane, QLD, 4072, Australia
  5. Queensland Institute of Medical Research, Brisbane, Australia
  2. Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
  10. School of Social and Community Medicine, University of Bristol, Bristol, UK
  3. MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
  4. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
  6. Department of Psychiatry, Washington University, St. Louis, MO, USA
  7. Department of Genetics and Psychiatry, University of North Carolina at Chapel Hill, CB# 7264, 5097 Genomic Medicine, Chapel Hill, NC, 27599-27264, USA
  11. University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia
  8. Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
  9. Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7570, USA
  
• ISSN：1435-1102

文摘

The etiology of major depressive disorder (MDD) is likely to be heterogeneous, but postpartum depression (PPD) is hypothesized to represent a more homogenous subset of MDD. We use genome-wide SNP data to explore this hypothesis. We assembled a total cohort of 1,420 self-report cases of PPD and 9,473 controls with genome-wide genotypes from Australia, The Netherlands, Sweden and the UK. We estimated the total variance attributable to genotyped variants. We used association results from the Psychiatric Genomics Consortia (PGC) of bipolar disorder (BPD) and MDD to create polygenic scores in PPD and related MDD data sets to estimate the genetic overlap between the disorders. We estimated that the percentage of variance on the liability scale explained by common genetic variants to be 0.22 with a standard error of 0.12, p--.02. The proportion of variance (R 2) from a logistic regression of PPD case/control status in all four cohorts on a SNP profile score weighted by PGC-BPD association results was small (0.1?%) but significant (p--.004) indicating a genetic overlap between BPD and PPD. The results were highly significant in the Australian and Dutch cohorts (R 2--.1?%, p--.008), where the majority of cases met criteria for MDD. The genetic overlap between BPD and MDD was not significant in larger Australian and Dutch MDD case/control cohorts after excluding PPD cases (R 2--.06?%, p--.08), despite the larger MDD group affording more power. Our results suggest an empirical genetic evidence for a more important shared genetic etiology between BPD and PPD than between BPD and MDD.